1476776-55-2|tert-Butyl (3s)-3-(4-bromophenyl)-piperidine-1-carboxylate| Ambeed

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Quality Control of [ 1476776-55-2 ] Purity: 98% SDS Specification

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Product Details of [ 1476776-55-2 ]

CAS No. :	1476776-55-2
Formula :	C₁₆H₂₂BrNO₂
M.W :	340.26
SMILES Code :	O=C(N1C[C@H](C2=CC=C(Br)C=C2)CCC1)OC(C)(C)C
MDL No. :	MFCD27987933

Safety of [ 1476776-55-2 ]

GHS Pictogram:
Signal Word:	Warning
Hazard Statements:	H302-H315-H319-H335
Precautionary Statements:	P261-P305+P351+P338

Application In Synthesis of [ 1476776-55-2 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Upstream synthesis route of [ 1476776-55-2 ]
Downstream synthetic route of [ 1476776-55-2 ]

[ 1476776-55-2 ] Synthesis Path-Upstream 1~18

1
[ 24424-99-5 ]
[ 1335523-82-4 ]
[ 1476776-55-2 ]

Yield	Reaction Conditions	Operation in experiment
99%	With sodium hydroxide In water at 20 - 35℃;	In a 500 mL eggplant-shaped flask,15 g (36.4 mmol) of compound (6) and 1.5 g (36.4 mmol) of sodium hydroxide were added,150ml and 50ml water,Boc anhydride 9.5 g (43.7 mmol) was added dropwise.Stir at room temperature overnightTLC showed complete reaction,Separate the organic layer,Sodium sulfate drying,It was concentrated by filtration to obtain 12.3 g of an oily compound (7).The yield is 99percent.98.1percent purity.
11.2 g	With dmap; triethylamine In dichloromethane at 20℃; for 8 h;	Example 7 Compound 8 (9.20 g, 0.038 mol) was added 60 mL of dichloromethane, di-tert-butyl dicarbonate (10.8 g, 0.05 mol), triethylamine (5.70 g, 0.057 mol), DMAP (0.460 g, 3.80 mmol) was reacted at room temperature for 8 hours. The reaction was washed with saturated sodium bicarbonate and dried over anhydrous sodium sulfate. The organic phase was evaporated to dryness to give 11.2 g of a pale yellow solid.

References: [1] Patent: CN107663190, 2018, A, . Location in patent: Paragraph 0075; 0076; 0077.
[2] Patent: CN106854176, 2017, A, . Location in patent: Paragraph 0046; 0047.

2
[ 1476776-66-5 ]
[ 1476776-55-2 ]

References: [1] Organic Process Research and Development, 2014, vol. 18, # 1, p. 215 - 227.

3
[ 24424-99-5 ]
[ 1476776-53-0 ]
[ 1476776-55-2 ]

References: [1] Organic Process Research and Development, 2014, vol. 18, # 1, p. 215 - 227.

4
[ 6340-79-0 ]
[ 1476776-55-2 ]

References: [1] Organic Process Research and Development, 2014, vol. 18, # 1, p. 215 - 227.
[2] Organic Process Research and Development, 2014, vol. 18, # 1, p. 215 - 227.

5
[ 1284448-67-4 ]
[ 1476776-55-2 ]

References: [1] Organic Process Research and Development, 2014, vol. 18, # 1, p. 215 - 227.
[2] Organic Process Research and Development, 2014, vol. 18, # 1, p. 215 - 227.

6
[ 1476776-39-2 ]
[ 1476776-55-2 ]

References: [1] Organic Process Research and Development, 2014, vol. 18, # 1, p. 215 - 227.
[2] Organic Process Research and Development, 2014, vol. 18, # 1, p. 215 - 227.

7
[ 1476776-40-5 ]
[ 1476776-55-2 ]

References: [1] Organic Process Research and Development, 2014, vol. 18, # 1, p. 215 - 227.
[2] Organic Process Research and Development, 2014, vol. 18, # 1, p. 215 - 227.

8
[ 108-86-1 ]
[ 1476776-55-2 ]

References: [1] Organic Process Research and Development, 2014, vol. 18, # 1, p. 215 - 227.
[2] Organic Process Research and Development, 2014, vol. 18, # 1, p. 215 - 227.

9
[ 1476776-44-9 ]
[ 1476776-55-2 ]

References: [1] Organic Process Research and Development, 2014, vol. 18, # 1, p. 215 - 227.

10
[ 1335523-82-4 ]
[ 1476776-55-2 ]

References: [1] Organic Process Research and Development, 2014, vol. 18, # 1, p. 215 - 227.

11
[ 1476776-62-1 ]
[ 1476776-55-2 ]

References: [1] Organic Process Research and Development, 2014, vol. 18, # 1, p. 215 - 227.

12
[ 1476776-64-3 ]
[ 1476776-55-2 ]

References: [1] Organic Process Research and Development, 2014, vol. 18, # 1, p. 215 - 227.

13
[ 1476776-61-0 ]
[ 1476776-55-2 ]

References: [1] Organic Process Research and Development, 2014, vol. 18, # 1, p. 215 - 227.

14
[ 1008-88-4 ]
[ 1476776-55-2 ]

References: [1] Patent: CN106854176, 2017, A, .

15
[ 129013-83-8 ]
[ 1476776-55-2 ]

References: [1] Patent: CN106854176, 2017, A, .

16
[ 769944-72-1 ]
[ 1476776-55-2 ]

References: [1] Patent: CN106854176, 2017, A, .

17
[ 204851-47-8 ]
[ 1476776-55-2 ]

References: [1] Patent: CN107311911, 2017, A, .

18
[ 1878-68-8 ]
[ 1476776-55-2 ]

References: [1] Patent: CN107311911, 2017, A, .

Historical Records

Technical Information

• Acyl Group Substitution • Alkyl Halide Occurrence • Chan-Lam Coupling Reaction • Complex Metal Hydride Reductions • General Reactivity • Grignard Reaction • Hiyama Cross-Coupling Reaction • Hydride Reductions • Kinetics of Alkyl Halides • Kumada Cross-Coupling Reaction • Lawesson's Reagent • Preparation of Amines • Reactions of Alkyl Halides with Reducing Metals • Reactions of Amines • Reactions of Benzene and Substituted Benzenes • Reactions of Dihalides • Specialized Acylation Reagents-Carbodiimides and Related Reagents • Specialized Acylation Reagents-Ketenes • Stille Coupling • Substitution and Elimination Reactions of Alkyl Halides • Suzuki Coupling

Related Functional Groups of
[ 1476776-55-2 ]

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Amides

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Related Parent Nucleus of
[ 1476776-55-2 ]

Piperidines

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Similarity: 0.85

A123854 [1251015-16-3]

tert-Butyl 5-bromo-2H-spiro[benzofuran-3,4'-piperidine]-1'-carboxylate

Similarity: 0.83

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H412	Harmful to aquatic life with long-lasting effects
H413	May cause long-lasting harmful effects to aquatic life
H420	Harms public health and the environment by destroying ozone in the upper atmosphere

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CAS No.: 1476776-55-2

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