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Chemical Structure| 159191-44-3 Chemical Structure| 159191-44-3

Structure of 159191-44-3

Chemical Structure| 159191-44-3

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Product Details of [ 159191-44-3 ]

CAS No. :159191-44-3
Formula : C20H20BNO2
M.W : 317.19
SMILES Code : OB(C1=CC=C(N(CC2=CC=CC=C2)CC3=CC=CC=C3)C=C1)O
MDL No. :MFCD06798225

Safety of [ 159191-44-3 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Application In Synthesis of [ 159191-44-3 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 159191-44-3 ]

[ 159191-44-3 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 27741-65-7 ]
  • [ 159191-44-3 ]
  • [ 1227159-94-5 ]
YieldReaction ConditionsOperation in experiment
54% With potassium hydroxide; In 1,4-dioxane; dichloromethane; Step 1: Ethyl {1-[4-(dibenzylamino)phenyl]cyclobutyl}acetate 440 mg (0.892 mmol) of bis[(1,5-cyclooctadiene)rhodium(I) chloride] were initially introduced into 20 ml of 1,4-dioxane and 15.5 ml (23.2 mmol) of 1.5 M potassium hydroxide solution were added. A solution of 2.5 g (17.8 mmol) of <strong>[27741-65-7]cyclobutylidene-acetic acid ethyl ester</strong> [M. Afzal et al., J. Chem. Soc. Perkin Trans. 2, 1999 (5), 937-946] in 1 ml of 1,4-dioxane was then added. A solution of 5.66 g (17.8 mmol) of the compound from Example 4A/step 1 in 100 ml of 1,4-dioxane was then added. After the reaction mixture had been stirred at RT for 16 h, it was concentrated to dryness on a rotary evaporator. The residue obtained was dissolved in a little methylene chloride and prepurified by means of filtration with suction over approx. 100 g of silica gel with methylene chloride as the mobile phase. The product was isolated in a pure form by means of MPLC (approx. 300 g of silica gel, mobile phase: cyclohexane/methylene chloride 100:0,?50:50). 4.02 g (54% of th.) of the title compound were obtained. 1H-NMR (400 MHz, CDCl3, delta/ppm): 7.32-7.30 (m, 4H), 7.26-7.21 (m, 6H), 6.97 (d, 2H), 6.67 (d, 2H), 4.61 (s, 4H), 3.93 (quart, 2H), 2.70 (s, 2H), 2.43-2.28 (m, 4H), 2.07-1.96 (m, 1H), 1.88-1.78 (m, 1H).
 

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