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Chemical Structure| 15732-02-2 Chemical Structure| 15732-02-2

Structure of 15732-02-2

Chemical Structure| 15732-02-2

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Product Details of [ 15732-02-2 ]

CAS No. :15732-02-2
Formula : C5H7NO2
M.W : 113.12
SMILES Code : N#C/C=C(OC)/OC
MDL No. :MFCD09908209

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Application In Synthesis of [ 15732-02-2 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 15732-02-2 ]

[ 15732-02-2 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 15732-02-2 ]
  • [ 32326-25-3 ]
YieldReaction ConditionsOperation in experiment
70.6% With sodium hydroxide; hydroxylamine hydrochloride; In methanol; water; (B) To a solution of hydroxylamine hydrochloride (1.55 g, 22.3 mmol) in water (3.41 ml) was added 8N aqueous sodium hydroxide solution (3.35 ml; 26.8 mmol) under stirring at room temperature. The temperature was elvated to 45 C. and a solution of 3,3-dimethoxyacrylonitrile (2.27 g; 20.1 mmol) in methanol (5.50 ml) was added dropwise for 30 minutes and then the mixture was stirred at the same temperature for 1 hour. After disappear of 3,3-dimethoxyacrylonitrile was apparent, 8N sodium hydroxide (1.25 ml; 10.1 mmol) was added to the mixture at the same temperature and the temperature was elevated to 60 C. The mixture was stirred for 6 hours. After the reaction was completed, the reaction mixture was directly concentrated (60 C./19 mmHg: until an inorganic compound was begun to precipitate). The obtained concentrate was extracted with ethyl acetate (5 ml*3) and the extract was dried over sodium sulfate and concentrated and the residue was dried under reduced pressure to give 3-amino-5-methoxyisoxazole (1.63 g; yield 70.6%) as white crystals. m.p. 82-83 C. (hexane-ethyl acetate) NMR delta (CDCl3): 3.93(5H,bs,CH3 +NH2), 4.81(1H,s,H-4) NMR delta (CDCl3 +D2 O): 3.93 (3H,s,CH3), 4.83(1H,s,H-4) IR (CHL3)cm-1: 3840, 1628, 1487. Anal. Calcd. for C4 H6 N2 O2: C,42.11;H,5.30; N 24.55(%). Found: C,41.74; H, 5.06; N, 24.35(%).
 

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