Structure of 1482-98-0
*Storage: {[sel_prStorage]}
*Shipping: {[sel_prShipping]}
The BI-3802 was designed by Boehringer Ingelheim and could be obtained free of charge through the Boehringer Ingelheim open innovation portal opnMe.com, associated with its negative control.
4.5
*For Research Use Only !
Change View
Size | Price | VIP Price | US Stock |
Global Stock |
In Stock | ||
{[ item.pr_size ]} |
Inquiry
{[ getRatePrice(item.pr_usd, 1,1,item.pr_is_large_size_no_price, item.pr_usd) ]} {[ getRatePrice(item.pr_usd,item.pr_rate,1,item.pr_is_large_size_no_price, item.discount_usd) ]} {[ getRatePrice(item.pr_usd, 1,1,item.pr_is_large_size_no_price, item.pr_usd) ]} |
Inquiry {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate,item.pr_is_large_size_no_price, item.vip_usd) ]} | Inquiry {[ item.pr_usastock ]} In Stock Inquiry - | {[ item.pr_chinastock ]} {[ item.pr_remark ]} In Stock 1-2 weeks - Inquiry - | Login | - + | Inquiry |
Please Login or Create an Account to: See VIP prices and availability
US Stock: ship in 0-1 business day
Global Stock: ship in 5-7 days
1-2weeks
Inquiry
{[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate,item.pr_is_large_size_no_price, item.vip_usd) ]}
{[ getRatePrice(item.pr_usd, 1,1,item.pr_is_large_size_no_price, item.pr_usd) ]}
{[ getRatePrice(item.pr_usd,1,item.mem_rate,item.pr_is_large_size_no_price, item.pr_usd) ]}
Inquiry
{[ getRatePrice(item.pr_usd,item.pr_rate,1,item.pr_is_large_size_no_price, item.vip_usd) ]}
{[ getRatePrice(item.pr_usd, 1,1,item.pr_is_large_size_no_price, item.pr_usd) ]}
{[ getRatePrice(item.pr_usd, 1,1,item.pr_is_large_size_no_price, item.pr_usd) ]}
In Stock
- +
Please Login or Create an Account to: See VIP prices and availability
US Stock: ship in 0-1 business day
Global Stock: ship in 2 weeks
Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.
Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.
Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.
Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.
Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.
CAS No. : | 1482-98-0 |
Formula : | C4H11ClN2O2 |
M.W : | 154.60 |
SMILES Code : | O=C(O)[C@@H](N)CCN.[H]Cl |
MDL No. : | MFCD01632031 |
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
96% | With 1,1,1,3,3,3-hexamethyl-disilazane; In acetonitrile; at 20℃; for 48.0h;Heating / reflux; | Step 1 : HMDS (67mL, 0.32mol) in ACN (5OmL) was added dropwise to a solution of 25a (5g, 32mmol) in ACN (5OmL) at room temperature. The resulting mixture was heated to reflux for 48h under the protection of N2. When the reaction was complete, the mixture was cooled, poured into cold methanol (5OmL) and stirred for 30min. The obtained mixture was evaporated to dryness and the residue was extracted with chloroform (150mL*3) under reflux. The combined chloroform solution was evaporated to provide crude 25b (3.1 g, 96%). |
96% | With 1,1,1,3,3,3-hexamethyl-disilazane; In acetonitrile; at 20℃; for 48.0h;Heating / reflux; | Example 25 Preparation of 5-[5-Fluoro-2-oxo-1,2-dihydro-indol-(3Z)-ylidenemethyl]-2,4-dimethyl-1H-pyrrole-3-carboxylic acid ((S)-2-oxo-pyrrolidin-3-yl)-amide Preparation of (S)-3-Amino-pyrrolidin-2-one Step 1: HMDS (67 mL, 0.32 mmol) in ACN (50 mL) was added dropwise to a solution of 25a (5 g, 32 mmol) in ACN (50 mL) at room temperature. The resulting mixture was heated to reflux for 48 h under the protection of N2. When the reaction was complete, the mixture was cooled, poured into cold methanol (50 mL) and stirred for 30 min. The obtained mixture was evaporated to dryness and the residue was extracted with chloroform (150 mL*3) under reflux. The combined chloroform solution was evaporated to provide crude 25b (3.1 g, 96%). |
82% | With 1,1,1,3,3,3-hexamethyl-disilazane; In acetonitrile; for 48.0h;Reflux; | Preparation of Compound 131Step 1:(3S)-3-aminopyrrolidin-2-one. A suspension of (S)-2, 4-diaminobutyric acid dihydrochloride (5.0 g, 27 mmol) and HMDS (65 mL) in MeCN (100 mL) was stirred at reflux for 48h. Reaction progress was monitored by TLC. After completion the reaction mixture was cooled in ice, quenched with MeOH (25 mL), concentrated, and the residue extracted with hot CHCI3 (3x 150 mL). The combined CHCI3 layer was concentrated to afford (35)-3-aminopyrrolidin-2-one (2.2 g, 82 %, brown solid). TLC: 30 % MeOH- CHCI3, Rf =0.5. MH+ = 100.9. XH NMR (DMSO-d6, 400MHz): 7.62 (bs, exchanged with D20; 1H), 3.21 (t, J=8.3Hz; 1H), 3.15-3.04 (m, 2H), 2.26-2.07 (m, 1H), 1.92 (bs, exchanged with D20; 1H), 1.70-1.57 (m, 1H). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
92% | With N-ethyl-N,N-diisopropylamine; In water; N,N-dimethyl-formamide; at 20℃; | L-2,4-Diaminobutyric acid dihydrochloride (0.20 g, 1.69 mmol) was dissolved in water (3.6 mL). Subsequently /V,/V-diisopropylethylamine (1.18 mL, 6.76 mmol), N,N- 5 dimethylformamide (7.2 mL) and 2,5-dioxopyrrolidin-l-yl 3-fluoro-4-(4, 4,5,5- tetramethyl-l,3,2-dioxaborolan-2-yl)benzoate (1, 1.23 g, 3.38 mmol) were added. The mixture was stirred overnight at room temperature; then it was acidified by 1 M aqueous solution of hydrochloric acid. The solvent was co-evaporated with toluene three times. The residue was dissolved in dichloromethane/toluene mixture (1 : 1, 100 mL). The 10 residue was dissolved in ethyl acetate (60 mL) and washed with water (3 x 40 mL). Organic layer was dried over anhydrous sodium sulfate, filtered and evaporated. The residue was dissolved in dichloromethane (3 mL) and product started to precipitate. Cyclohexane was added (35 mL). The precipitate was collected by filtration, washed with cyclohexane and dried in vacuo to yield 2,4-bis(4-(l,3,2-dioxaborolan-2-yl)-3- 15 fluorobenzamido)butanoic acid (2) as transparent oil. Yield : 960 mg (92%). JH NMR spectrum (300 MHz, CDCI3, deltaEta) : 7.90-7.75 (m, 2 H); 7.65-7.40 (m, 5 H); 7.11-7.02 (m, 1 H); 4.91-4.79 (m, 1 H); 3.58-3.50 (s, 2 H); 2.10-1.70 (m, 4 H); 1.36 (s, 24 H). 20 LC-MS purity: 100% (ELSD). LC-MS Rt (Kinetex C18, 4.6 mm x 50 mm, acetonitrile/water 05 :95 to 100 :0 + 0.1% FA) : 2.82 min, 3.56 min, 4.53 min. LC-MS m/z: 615.6 (M + H)+, 533.5 (M + H-pinacol)+, 451.4 (M + H-2 x pinacol)+. |