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Chemical Structure| 1454285-47-2 Chemical Structure| 1454285-47-2

Structure of 1454285-47-2

Chemical Structure| 1454285-47-2
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Product Details of [ 1454285-47-2 ]

CAS No. :1454285-47-2
Formula : C8H4ClNO3
M.W : 197.58
SMILES Code : ClC1=NC=C(O2)C(C=C2C(O)=O)=C1
MDL No. :MFCD28098347

Safety of [ 1454285-47-2 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P264-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P330-P332+P313-P337+P313-P362-P403+P233-P405-P501

Application In Synthesis of [ 1454285-47-2 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1454285-47-2 ]

[ 1454285-47-2 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 1454285-47-2 ]
  • [ 94341-56-7 ]
  • [ 1454285-48-3 ]
YieldReaction ConditionsOperation in experiment
400 mg With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; diisopropylamine; In N,N-dimethyl-formamide; at 20℃; A solution of the crude 5-chlorofuro[2,3-c]pyridine-2-carboxylic acid (800 mg, 4.05 mmol, 1.00 equiv), <strong>[94341-56-7][4-(benzenesulfonyl)phenyl]methanamine</strong> (520 mg, 2.10 mmol, 0.52 equiv), EDCI (400 mg, 2.09 mmol, 0.52 equiv), HOBt (283 mg, 2.09 mmol, 0.52 equiv) and diisopropylamine (2 mL) in DMF (10 mL) was stirred at rt overnight. The reaction mixture was diluted with 200 mL of ethyl acetate and washed with 100 mL of H2O. The organic layer was dried over anhydrous sodium sulfate, filtered and concentrated under vacuum. The residue was purified on a silica gel column eluted with ethyl acetate/petroleum ether (30: 100 to 50:100) to give 400 mg (23%) of N-[[4-(benzenesulfonyl)phenyl]methyl]-5-chlorofuro[2,3-c]pyridine-2-carboxamide as a white solid. TLC: DCM:MeOH = 10: 1 , Rf= 0.6.
 

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