144729-44-2|4-Chloro-3-nitrobenzene-1,2-diamine| Ambeed

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Quality Control of [ 144729-44-2 ] Purity: 95% SDS Specification

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Product Details of [ 144729-44-2 ]

CAS No. :	144729-44-2
Formula :	C₆H₆ClN₃O₂
M.W :	187.58
SMILES Code :	NC1C(N)=C([N+](=O)[O-])C(Cl)=CC=1
MDL No. :	MFCD02169899
InChI Key :	OHIUWWQDSMTIFW-UHFFFAOYSA-N
Pubchem ID :	3736824

Safety of [ 144729-44-2 ]

GHS Pictogram:
Signal Word:	Warning
Hazard Statements:	H302-H315-H319-H335
Precautionary Statements:	P261-P264-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P330-P332+P313-P337+P313-P362-P403+P233-P405-P501

Application In Synthesis of [ 144729-44-2 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Downstream synthetic route of [ 144729-44-2 ]

[ 144729-44-2 ] Synthesis Path-Downstream 1~28

1
[ 20718-46-1 ]
[ 144729-44-2 ]

Yield	Reaction Conditions	Operation in experiment
86%	With hydrogenchloride; hydrogen iodide; In water; at 20℃; for 2.0h;	At room temperature, an aqueous solution of hydroiodic acid (48%, 25 ml) was added to a solution of 5-chloro-4-nitro-benzo[1 ,2,5]selenadiazole (8.14 g, 31.01 mmol) in concentrated aqueous hydrochloric acid (76 ml). After 2 hours at room temperature, a 5% aqueous solution of NaHSO3 (150 ml) was added, and the mixture was stirred for 15 minutes. At 0 0C, concentrated aqueous NaOH solution was added until the pH value reached 8. The mixture was extracted with EtOAc. The combined organic layers were dried over Na2SO4, filtered and concentrated in vacuo to afford the title compound (4.98 g, 86%), which was used in the next transformation without further purification. 1H NMR (400 MHz, d6-acetone): δ = 6.81 (d, J = 7.7 Hz, 1H), 6.68 (d, J = 7.7 Hz, 1H), 5.12 (br s, 2H), 4.78 (br s, 2H). MS (ES ): 186.2 (M- H)-.
	With hydrogenchloride; hydrogen iodide; In water; at 20℃; for 2.0h;	A solution of 5-chloro-4-nitro-2,l,3-benzoselenadiazole from Step B (650 mg, 2.47 mmol) in cone. HCl (4 mL) and 48% aqueous HI (2 mL) was stirred at ambient temperature for 2 h. The reaction was diluted with a 1 : 1 saturated aqueous solution OfNaHSO4 and Na2CO3 (20 mL) and then adjusted to pH 10 using 10 M aqueous NaOH. The mixture was extracted with EtOAc (3 x 10 mL) and the organic extracts dried over Na2SO4, filtered, and concentrated in vacuo. The resulting dark red solid was dissolved in CH3CN (4 mL) and phosgene was added (20% solution in toluene, 1.5 mL, 3.2 mmol). The reaction mixture was stirred for 1 h, then diluted with toluene. Filtration of the resultant solid gave the title compound. MS: m/z = 214 (M + 1).
		A solution of 5-chloro-4-nitro-2,l,3-benzoselenadiazole from Step B (650 mg, 2.47 mmol) in cone. HCl (4 mL) and 48% aqueous HI (2 mL) was stirred at ambient temperature for 2 h. TheL 0 reaction was diluted with a 1 : 1 saturated aqueous solution OfNaHSO4 and Na2CO3 (20 mL) and then adjusted to pH 10 using 10 M aqueous NaOH. The mixture was extracted with EtOAc (3 x 10 mL) and the organic extracts dried over Na2SO4, filtered, and concentrated in vacuo. The resulting dark red solid was dissolved in CH3CN (4 mL) and phosgene was added (20% solution in toluene, 1.5 mL, 3.2 mmol). The reaction mixture was stirred for 1 h, then diluted with toluene. Filtration of the resultant solid gave15 the title compound. MS: m/z = 214 (M + 1).

	With hydrogenchloride; hydrogen iodide; In water; at 20℃; for 2.0h;	A solution of 5-chloro-4-nitro-2,l,3-benzoselenadiazole from Step B (650 mg, 2.47 mmol) in cone. HCl (4 mL) and 48% aqueous HI (2 mL) was stirred at ambient temperature for 2 h. The reaction was diluted with a 1:1 saturated aqueous solution of NaHSθ4 and Na2CO3 (20 mL) and then adjusted to pH 10 using 10 M aqueous NaOH. The mixture was extracted with EtOAc (3 x 10 mL) and the organic extracts dried over Na2Sθ4, filtered, and concentrated in vacuo. The resulting dark red solid was dissolved in CH3CN (4 mL) and phosgene was added (20% solution in toluene, 1.5 mL, 3.2 mmol). The reaction mixture was stirred for 1 h, then diluted with toluene. Filtration of the resultant solid gave the title compound. MS: m/z = 214 (M + 1).
45.7 mg	With hydrogenchloride; hydrogen iodide; In water;Cooling with ice;	[0104] The nitroselenadiazole (83.54 mg, 0.321 mmol) from the previous step was dissolved in cone. HCl (0.78 mL) and cooled in an ice bath. The reaction mixture was treated with a 48% HI solution (0.26 mL) followed by 50% NaOH to obtain a pH of 8. The product was extracted with ethyl acetate. The organic layer was washed with brine and concentrated under reduced pressure to provide S2 as a red powder (45.7 mg, 76%): XH NMR (400 MHz, Acetone-d6) 6.78 (d, 1H, J = 8.2 Hz), 6.68 (d, 1H, 8.2 Hz), 5.33 (bs, 2H), 5.18 (bs, 2H). LCMS (ESI) calc'd for [C6H7C1N302]+([M+H]+): m/z 188.0, found 188.0.

References: [1]Tetrahedron Letters,2005,vol. 46,p. 4613 - 4616.
[2]Journal of Medicinal Chemistry,1995,vol. 38,p. 4367 - 4379.
[3]Patent: WO2007/6533,2007,A2 .Location in patent: Page/Page column 42.
[4]Journal of Heterocyclic Chemistry,1992,vol. 29,p. 1305 - 1308.
[5]Russian Journal of General Chemistry,2004,vol. 74,p. 428 - 437.
[6]Synthesis,1992,p. 1283 - 1286.
[7]Journal of Organic Chemistry,1995,vol. 60,p. 5838 - 5842.
[8]Patent: WO2006/31676,2006,A2 .Location in patent: Page/Page column 54.
[9]Patent: WO2007/61692,2007,A2 .Location in patent: Page/Page column 114.
[10]Patent: WO2006/31491,2006,A2 .Location in patent: Page/Page column 78.
[11]Journal of Medicinal Chemistry,2013,vol. 56,p. 1739 - 1747.
[12]Patent: WO2014/78479,2014,A2 .Location in patent: Paragraph 0104.

2
[ 131543-46-9 ]
[ 144729-44-2 ]
[ 150536-27-9 ]

References: [1]Journal of Heterocyclic Chemistry,1992,vol. 29,p. 1305 - 1308.

3
[ 144729-44-2 ]
[ 431-03-8 ]
[ 150536-31-5 ]

References: [1]Journal of Heterocyclic Chemistry,1992,vol. 29,p. 1305 - 1308.

4
[ 144729-44-2 ]
[ 134-81-6 ]
[ 150536-36-0 ]

References: [1]Journal of Heterocyclic Chemistry,1992,vol. 29,p. 1305 - 1308.

5
[ 144729-44-2 ]
[ 123-54-6 ]
5-Chloro-2-methyl-4-nitrobenzimidazole [ No CAS ]

References: [1]Synthesis,1992,p. 1283 - 1286.

6
[ 144729-44-2 ]
[ 78-98-8 ]
6-chloro-2-methyl-5-nitro-quinoxaline [ No CAS ]
7-chloro-2-methyl-8-nitro-quinoxaline [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	With hydrogenchloride; In tetrahydrofuran; water; at 20 - 65℃; for 0.166667h;	At room temperature, 2-oxo-propionaldehyde (40% aqueous solution, 3.03 ml, 20.15 mmol, 1.0 equiv) was added to a solution of 4-chloro-3-nitro-benzene-1 ,2-diamine (3.78 g, 20.15 mmol) in THF (600 ml) and aqueous HCI (5N, 9.5 ml). The mixture was warmed to 65 0C for 10 minutes, then it was concentrated to approximately 200 ml and extracted with EtOAc. The combined organic layers were washed with dilute aqueous NaHCO3 solution and brine, dried over Na2SO4, filtered and concentrated in vacuo. The residue was purified via flash chromatography (gradient of hexane / EtOAc 9 : 1 to 7 : 3) to afford the title compound (3.86 g, 81%, 92 : 8 mixture of 7-chloro-2-methyl-8-nitro-quinoxaline and 6-chloro-2-methyl-5-nitro- quinoxaline). 1H NMR (400 MHz, CDCI3): δ = 8.81 (s, 1H), 8.15 (d, J = 9.1 Hz, 1H), 7.74 (d, J = 9.1 Hz, 1H), 2.79 (s, 3H). MS (ES+): 224 (M+H)

References: [1]Journal of Chemical Research, Miniprint,1992,p. 2701 - 2712.
[2]Journal of Chemical Research, Miniprint,1992,p. 2701 - 2712.
[3]Journal of Chemical Research, Miniprint,1992,p. 2701 - 2712.
[4]Patent: WO2007/6533,2007,A2 .Location in patent: Page/Page column 42.

7
[ 144-62-7 ]
[ 144729-44-2 ]
[ 167415-26-1 ]

References: [1]Journal of Medicinal Chemistry,1995,vol. 38,p. 4367 - 4379.
[2]Journal of Organic Chemistry,1995,vol. 60,p. 5838 - 5842.

8
[ 75-15-0 ]
[ 144729-44-2 ]
[ 548457-87-0 ]

References: [1]Tetrahedron Letters,2005,vol. 46,p. 4613 - 4616.

9
[ 18381-20-9 ]
[ 144729-44-2 ]
[ 150536-27-9 ]

References: [1]Russian Journal of General Chemistry,2004,vol. 74,p. 428 - 437.

10
[ 6343-86-8 ]
[ 144729-44-2 ]

References: [1]Russian Journal of General Chemistry,2004,vol. 74,p. 428 - 437.
[2]Tetrahedron Letters,2005,vol. 46,p. 4613 - 4616.
[3]Journal of Organic Chemistry,1995,vol. 60,p. 5838 - 5842.
[4]Journal of Medicinal Chemistry,1995,vol. 38,p. 4367 - 4379.
[5]Journal of Medicinal Chemistry,2013,vol. 56,p. 1739 - 1747.
[6]Patent: WO2014/78479,2014,A2 .

11
[ 95-83-0 ]
[ 144729-44-2 ]

References: [1]Russian Journal of General Chemistry,2004,vol. 74,p. 428 - 437.
[2]Journal of Organic Chemistry,1995,vol. 60,p. 5838 - 5842.
[3]Journal of Medicinal Chemistry,1995,vol. 38,p. 4367 - 4379.
[4]Journal of Medicinal Chemistry,2013,vol. 56,p. 1739 - 1747.
[5]Patent: WO2014/78479,2014,A2 .

12
[ 89-63-4 ]
[ 144729-44-2 ]

References: [1]Russian Journal of General Chemistry,2004,vol. 74,p. 428 - 437.

13
[ 144729-44-2 ]
[ 548457-89-2 ]

References: [1]Tetrahedron Letters,2005,vol. 46,p. 4613 - 4616.

14
[ 144729-44-2 ]
[ 862179-87-1 ]

References: [1]Tetrahedron Letters,2005,vol. 46,p. 4613 - 4616.

15
[ 144729-44-2 ]
[ 548457-88-1 ]

References: [1]Tetrahedron Letters,2005,vol. 46,p. 4613 - 4616.

16
[ 144729-44-2 ]
[ 862179-89-3 ]

References: [1]Tetrahedron Letters,2005,vol. 46,p. 4613 - 4616.

17
[ 144729-44-2 ]
[ 862179-93-9 ]

References: [1]Tetrahedron Letters,2005,vol. 46,p. 4613 - 4616.

18
[ 144729-44-2 ]
3-(5-chloro-2-methylsulfanyl-1H-benzoimidazol-4-yl)-acrylamide [ No CAS ]

References: [1]Tetrahedron Letters,2005,vol. 46,p. 4613 - 4616.

19
[ 144729-44-2 ]
[ 862179-91-7 ]

References: [1]Tetrahedron Letters,2005,vol. 46,p. 4613 - 4616.

20
[ 144729-44-2 ]
N-(5-chloro-2-phenylsulfanyl-3H-benzoimidazol-4-yl)-acetamide [ No CAS ]

References: [1]Tetrahedron Letters,2005,vol. 46,p. 4613 - 4616.

21
[ 144729-44-2 ]
[ 862179-95-1 ]

References: [1]Tetrahedron Letters,2005,vol. 46,p. 4613 - 4616.

22
[ 1635-61-6 ]
sodium hypochlorite [ No CAS ]
[ 144729-44-2 ]

References: [1]Journal of Organic Chemistry,1995,vol. 60,p. 5838 - 5842.
[2]Journal of Medicinal Chemistry,1995,vol. 38,p. 4367 - 4379.

23
[ 144729-44-2 ]
[ 153504-83-7 ]

References: [1]Journal of Medicinal Chemistry,1995,vol. 38,p. 4367 - 4379.

24
[ 75-44-5 ]
[ 144729-44-2 ]
[ 880087-29-6 ]

Yield	Reaction Conditions	Operation in experiment
	In toluene; acetonitrile; for 1.0h;	A solution of 5-chloro-4-nitro-2,l,3-benzoselenadiazole from Step B (650 mg, 2.47 mmol) in cone. HCl (4 mL) and 48% aqueous HI (2 mL) was stirred at ambient temperature for 2 h. The reaction was diluted with a 1 : 1 saturated aqueous solution OfNaHSO4 and Na2CO3 (20 mL) and then adjusted to pH 10 using 10 M aqueous NaOH. The mixture was extracted with EtOAc (3 x 10 mL) and the organic extracts dried over Na2SO4, filtered, and concentrated in vacuo. The resulting dark red solid was dissolved in CH3CN (4 mL) and phosgene was added (20% solution in toluene, 1.5 mL, 3.2 mmol). The reaction mixture was stirred for 1 h, then diluted with toluene. Filtration of the resultant solid gave the title compound. MS: m/z = 214 (M + 1).
	In toluene; acetonitrile; for 1.0h;	A solution of 5-chloro-4-nitro-2,l,3-benzoselenadiazole from Step B (650 mg, 2.47 mmol) in cone. HCl (4 mL) and 48% aqueous HI (2 mL) was stirred at ambient temperature for 2 h. TheL 0 reaction was diluted with a 1 : 1 saturated aqueous solution OfNaHSO4 and Na2CO3 (20 mL) and then adjusted to pH 10 using 10 M aqueous NaOH. The mixture was extracted with EtOAc (3 x 10 mL) and the organic extracts dried over Na2SO4, filtered, and concentrated in vacuo. The resulting dark red solid was dissolved in CH3CN (4 mL) and phosgene was added (20% solution in toluene, 1.5 mL, 3.2 mmol). The reaction mixture was stirred for 1 h, then diluted with toluene. Filtration of the resultant solid gave15 the title compound. MS: m/z = 214 (M + 1).
	In toluene; acetonitrile; for 1.0h;	A solution of 5-chloro-4-nitro-2,l,3-benzoselenadiazole from Step B (650 mg, 2.47 mmol) in cone. HCl (4 mL) and 48% aqueous HI (2 mL) was stirred at ambient temperature for 2 h. The reaction was diluted with a 1:1 saturated aqueous solution of NaHSθ4 and Na2CO3 (20 mL) and then adjusted to pH 10 using 10 M aqueous NaOH. The mixture was extracted with EtOAc (3 x 10 mL) and the organic extracts dried over Na2Sθ4, filtered, and concentrated in vacuo. The resulting dark red solid was dissolved in CH3CN (4 mL) and phosgene was added (20% solution in toluene, 1.5 mL, 3.2 mmol). The reaction mixture was stirred for 1 h, then diluted with toluene. Filtration of the resultant solid gave the title compound. MS: m/z = 214 (M + 1).

References: [1]Patent: WO2006/31676,2006,A2 .Location in patent: Page/Page column 54.
[2]Patent: WO2007/61692,2007,A2 .Location in patent: Page/Page column 114.
[3]Patent: WO2006/31491,2006,A2 .Location in patent: Page/Page column 78.

25
[ 144729-44-2 ]
[ 122-51-0 ]
[ 32046-86-9 ]

Yield	Reaction Conditions	Operation in experiment
72%	With toluene-4-sulfonic acid; In tetrahydrofuran; at 50℃; for 2.0h;	Step 2: S3 [0105] S3 was prepared analogously to a literature procedure (Valdez, J.; Cedillo, R.; Henandez-Campos, A.; Yepez, L.; Hernandez-Luis, F.; Navarrete- Vazquez, G.; Tapia, A.; Cortes, R.; Hernandez, M.; Castillo, R. Bioorg. Med. Chem. Lett. 2002, 12, 2221-2224): A solution of S2 (75 mg, 0.40 mmol) in THF (1.5 mL) was treated sequentially with triethyl orthoformate (178 mg, 1.2 mmol) and -toluenesulfonic acid (7.6 mg, 200 μ, 0.04 mmol). The reaction mixture was stirred at 50 C, the reaction was monitored by LCMS. After 2 h, the solvent was removed under a stream of nitrogen gas, and the resulting residue was partitioned between ethyl acetate and water. The organic layer was washed with saturated aqueous a2C03, dried over MgS04, and concentrated under reduced pressure to provide S3 as a light brown solid (57 mg, 72%): XH NMR (400 MHz, Acetone-d6) 8.42 (s, 1H), 8.03 (d, 1H, J = 8.2 Hz), 7.87 (d, 1H, J = 8.2 Hz), 7.48 (bs, 1H). LCMS (ESI) calc'd for [C7H5C1N302]"([M-H]"): m/z 198.0, found 198.0.

References: [1]Journal of Medicinal Chemistry,2013,vol. 56,p. 1739 - 1747.
[2]Patent: WO2014/78479,2014,A2 .Location in patent: Paragraph 0105.

26
[ 506-68-3 ]
[ 144729-44-2 ]
[ 1422955-35-8 ]

Yield	Reaction Conditions	Operation in experiment
41%	In water; acetonitrile; at 0℃;	Step 1 : B2 S4 [0107] S4 was prepared analogously to a literature procedure (Valdez, J.; Cedillo, R.; Henandez-Campos, A.; Yepez, L.; Hernandez-Luis, F.; Navarrete- Vazquez, G.; Tapia, A.; Cortes, R.; Hernandez, M.; Castillo, R. Bioorg. Med. Chem. Lett. 2002, 12, 2221-2224): S2 (75 mg, 0.40 mmol) was dissolved in a 5: 1 mixture of CH3CN and water (1.2 mL) and cooled to 0 C. The dark red solution was treated with cyanogen bromide (47 mg, 0.44 mmol), and the reaction was monitored by LCMS. At the completion of the reaction, the solvent was removed under a stream of nitrogen gas. Cone, ammonium hydroxide was added, which resulted in a dark red precipitate formation that was filtered via vacuum filtration. The precipitate was washed repeatedly with cold water and dried under vacuum. Purification via flash chromatography on silica gel (15% ethyl acetate in hexanes) provided the desired product S4 as a red powder (35.0 mg, 41 %): XH NMR (CDC13, 400 MHz) 6.82 (bs, 2H), 6.78 (d, 1H, J = 8.2 Hz), 6.68 (d, 1H, J = 8.2 Hz), 5.33 (bs, 1H). LCMS (ESI) calc'd for [C7H4C1N402]"([M-H]"): m/z 211.0, found 211.0.

References: [1]Journal of Medicinal Chemistry,2013,vol. 56,p. 1739 - 1747.
[2]Patent: WO2014/78479,2014,A2 .Location in patent: Paragraph 0107.

27
[ 144729-44-2 ]
[ 1422955-34-7 ]

References: [1]Journal of Medicinal Chemistry,2013,vol. 56,p. 1739 - 1747.

28
[ 144729-44-2 ]
[ 1422955-36-9 ]

References: [1]Journal of Medicinal Chemistry,2013,vol. 56,p. 1739 - 1747.

Historical Records

Technical Information

• Alkyl Halide Occurrence • Buchwald-Hartwig C-N Bond and C-O Bond Formation Reactions • Chan-Lam Coupling Reaction • General Reactivity • Grignard Reaction • Hiyama Cross-Coupling Reaction • Hydride Reductions • Kinetics of Alkyl Halides • Kumada Cross-Coupling Reaction • Leuckart-Wallach Reaction • Mannich Reaction • Petasis Reaction • Preparation of Amines • Reactions of Alkyl Halides with Reducing Metals • Reactions of Amines • Specialized Acylation Reagents-Vilsmeier Reagent • Stille Coupling • Substitution and Elimination Reactions of Alkyl Halides • Suzuki Coupling • Ugi Reaction

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P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P370 + P376	In case of fire: Stop leak if safe to Do so.
P370 + P378	In case of fire:
P370 + P380	In case of fire: Evacuate area.
P370 + P380 + P375	In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion.
P371 + P380 + P375	In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion.
Storage
Code	Phrase
P401
P402	Store in a dry place.
P403	Store in a well-ventilated place.
P404	Store in a closed container.
P405	Store locked up.
P406	Store in corrosive resistant/ container with a resistant inner liner.
P407	Maintain air gap between stacks/pallets.
P410	Protect from sunlight.
P411
P412	Do not expose to temperatures exceeding 50 oC/ 122 oF.
P413
P420	Store away from other materials.
P422
P402 + P404	Store in a dry place. Store in a closed container.
P403 + P233	Store in a well-ventilated place. Keep container tightly closed.
P403 + P235	Store in a well-ventilated place. Keep cool.
P410 + P403	Protect from sunlight. Store in a well-ventilated place.
P410 + P412	Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF.
P411 + P235	Keep cool.
Disposal
Code	Phrase
P501	Dispose of contents/container to ...
P502	Refer to manufacturer/supplier for information on recovery/recycling

Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed
H304	May be fatal if swallowed and enters airways
H305	May be harmful if swallowed and enters airways
H310	Fatal in contact with skin
H311	Toxic in contact with skin
H312	Harmful in contact with skin
H313	May be harmful in contact with skin
H314	Causes severe skin burns and eye damage
H315	Causes skin irritation
H316	Causes mild skin irritation
H317	May cause an allergic skin reaction
H318	Causes serious eye damage
H319	Causes serious eye irritation
H320	Causes eye irritation
H330	Fatal if inhaled
H331	Toxic if inhaled
H332	Harmful if inhaled
H333	May be harmful if inhaled
H334	May cause allergy or asthma symptoms or breathing difficulties if inhaled
H335	May cause respiratory irritation
H336	May cause drowsiness or dizziness
H340	May cause genetic defects
H341	Suspected of causing genetic defects
H350	May cause cancer
H351	Suspected of causing cancer
H360	May damage fertility or the unborn child
H361	Suspected of damaging fertility or the unborn child
H361d	Suspected of damaging the unborn child
H362	May cause harm to breast-fed children
H370	Causes damage to organs
H371	May cause damage to organs
H372	Causes damage to organs through prolonged or repeated exposure
H373	May cause damage to organs through prolonged or repeated exposure
Environmental hazards
Code	Phrase
H400	Very toxic to aquatic life
H401	Toxic to aquatic life
H402	Harmful to aquatic life
H410	Very toxic to aquatic life with long-lasting effects
H411	Toxic to aquatic life with long-lasting effects
H412	Harmful to aquatic life with long-lasting effects
H413	May cause long-lasting harmful effects to aquatic life
H420	Harms public health and the environment by destroying ozone in the upper atmosphere

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CAS No.: 144729-44-2

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CAS No.: 144729-44-2

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[ 144729-44-2 ] Synthesis Path-Downstream 1~28

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