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Chemical Structure| 14425-64-0 Chemical Structure| 14425-64-0

Structure of 14425-64-0

Chemical Structure| 14425-64-0

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Product Details of [ 14425-64-0 ]

CAS No. :14425-64-0
Formula : C9H11BrO
M.W : 215.09
SMILES Code : COC1=CC=C(CCBr)C=C1
MDL No. :MFCD07369786
InChI Key :OXHPTABOQVHKLN-UHFFFAOYSA-N
Pubchem ID :84427

Safety of [ 14425-64-0 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302
Precautionary Statements:P264-P270-P301+P312+P330-P501

Application In Synthesis of [ 14425-64-0 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 14425-64-0 ]

[ 14425-64-0 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 14425-64-0 ]
  • [ 124-40-3 ]
  • [ 539-15-1 ]
YieldReaction ConditionsOperation in experiment
40% A solution of 4-methoxyphenethyl bromide (0.20 g, 0.93 mmol) and dimethylamine (2.0 M in THF, 2 ml) was stirred in a sealed-tube at rt for 18 h. The reaction mixture was concentrated in vacuo and re-dissolved in dichloromethane (2 ml). After cooling to 0 C., boron tribromide (1.0 M in hexane, 1.00 ml) was added dropwise, and the solution was stirred at this temperature for 10 min. Water (20 ml) was added dropwise and the mixture was stirred for further 30 min. After warming to rt, the reaction mixture was extracted with dichloromethane (3×20 ml). The combined organic layers were washed with brine (30 ml), dried over sodium sulfate, and then concentrated in vacuo. Purification by flash chromatography on silica (aqueous ammonia solution/methanol/dichloromethane, 5:20:75) afforded the titled compound as a white solid (61 mg, 40%).1H NMR (400 MHz; CD4OD) 2.31 (6H, s), 2.54 (2H, m, CH2), 2.65 (2H, m, CH2), 6.67 (2H, d, J 8.4 Hz, Ph-H), 6.99 (2H, d, J 8.4 Hz, Ph-H);13C NMR (100 MHz; CD4OD) 34.5, 46.1, 63.5, 117.2, 131.4 and 132.3, 157.8;m/z (+ES) 166 (100, MH+).
  • 2
  • [ 6374-91-0 ]
  • [ 14425-64-0 ]
  • [ 1020264-99-6 ]
 

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