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Chemical Structure| 1426321-08-5 Chemical Structure| 1426321-08-5

Structure of 1426321-08-5

Chemical Structure| 1426321-08-5

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Product Details of [ 1426321-08-5 ]

CAS No. :1426321-08-5
Formula : C14H16BClO3
M.W : 278.54
SMILES Code : CC1(C)C(C)(C)OB(C2=CC3=C(OC=C3)C(Cl)=C2)O1

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Application In Synthesis of [ 1426321-08-5 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1426321-08-5 ]

[ 1426321-08-5 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 1426321-08-5 ]
  • [ 6627-22-1 ]
  • [ 1426321-09-6 ]
YieldReaction ConditionsOperation in experiment
With potassium phosphate; palladium bis[bis(diphenylphosphino)ferrocene] dichloride; In N,N-dimethyl-formamide; at 60℃; for 16h;Inert atmosphere; Tripotassium phosphate (1.4eq) was added in one portion to a stirred solution of, 7-chloro-5-(4,4,5,5-tetramethyl- [l,3,2]dioxaborolan-2-yl)-benzofuran (leq) and <strong>[6627-22-1]methyl 6-chloropyrimidine-4-carboxylate</strong> (2eq) in DMF (4vol). The mixture was degassed with nitrogen for 5 minutes, after which time Pd(dppf)2C12 (0.2eq) was added in one portion, the mixture was then heated to 60oC and stirred at this temperature for 16 hours under a nitrogen atmosphere. After this time the reaction mixture was cooled to room temperature and partitioned between ethyl acetate (20vol) and water (lOvol). The organic layer was separated, washed sequentially with water (lOvol) then brine (lOvol) before being dried (MgS04), filtered and concentrated. The resulting residue was purified purified using a Biotage Isolera (50g silica column eluting with 100% heptane to 20% ethyl acetate / 50% heptane) to afford the desired compound as a white solid.
 

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