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Chemical Structure| 1426320-86-6 Chemical Structure| 1426320-86-6

Structure of 1426320-86-6

Chemical Structure| 1426320-86-6

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Product Details of [ 1426320-86-6 ]

CAS No. :1426320-86-6
Formula : C13H16BClO3
M.W : 266.53
SMILES Code : O=CC1=CC=C(B2OC(C)(C)C(C)(C)O2)C=C1Cl
MDL No. :MFCD18732923
InChI Key :ZFMDSLNRXFTCOA-UHFFFAOYSA-N
Pubchem ID :89423145

Safety of [ 1426320-86-6 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H315-H319-H335
Precautionary Statements:P261-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P362-P403+P233-P501

Application In Synthesis of [ 1426320-86-6 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1426320-86-6 ]

[ 1426320-86-6 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 1426320-86-6 ]
  • [ 6627-22-1 ]
  • [ 1426320-87-7 ]
YieldReaction ConditionsOperation in experiment
0.1 g To a degassed stirred solution of ethyl 6-chloropyrimidine-4-carboxylate (0.17 g, 0.9 mmol) and 2-chloro-4- (tetramethyl-l,3,2-dioxaborolan-2-yl)benzaldehyde (0.22 g, 0.81 mmol) in dioxane (2.5 mL) was added 2M K2C03 (1.25 mL). Pd(PPh3)4 (57 mg, 0.05 mmol) was then added and the reaction mixture was further degassed before heating to 90C under an atmosphere of nitrogen gas for 2 hours. After this time, the reaction mixture was cooled to room temperature and concentrated. Water (5 mL) was then added and the solid filtered, washed with water (2 mL), acetone (3 x 2 mL) and dried under vacuum. The solid was suspended in a mixture of EtOAc (30 mL) and IN HC1 (10 mL) and then heated to achieve partial solution. The cooled two-phase system was then sonicated to achieve full dissolution. The aqueous layer was re-extracted with EtOAc (10 mL); the combined organics were washed with brine (5 mL), dried (MgS04), filtered and concentrated to give the desired compound (0.1 g, 42%> yield (at) 85%> purity) as a beige solid. Tr = 1.58 min m/z (ES+) (M+H+) 263/265.
  • 2
  • [ 1426320-86-6 ]
  • [ 6627-22-1 ]
  • [ 1426320-17-3 ]
 

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