Structure of Chloroaluminum Phthalocyanine
CAS No.: 14154-42-8
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CAS No. : | 14154-42-8 |
Formula : | C32H16AlClN8 |
M.W : | 574.96 |
SMILES Code : | C1(C([N-]C(C2=CC=CC=C2/3)=NC3=N/4)=N/5)=CC=CC=C1C5=N\C(C6=CC=CC=C6/7)=NC7=N/C8=C9C=CC=CC9=C4[N-]8.[Al+3].[Cl-] |
MDL No. : | MFCD00049386 |
GHS Pictogram: | ![]() |
Signal Word: | Warning |
Hazard Statements: | H302-H315-H319-H335 |
Precautionary Statements: | P261-P273-P280-P305+P351+P338 |
Num. heavy atoms | 42 |
Num. arom. heavy atoms | 27 |
Fraction Csp3 | 0.0 |
Num. rotatable bonds | 0 |
Num. H-bond acceptors | 8.0 |
Num. H-bond donors | 0.0 |
Molar Refractivity | 186.7 |
TPSA ? Topological Polar Surface Area: Calculated from | 87.05 Ų |
Log Po/w (iLOGP)? iLOGP: in-house physics-based method implemented from | 0.0 |
Log Po/w (XLOGP3)? XLOGP3: Atomistic and knowledge-based method calculated by | 7.16 |
Log Po/w (WLOGP)? WLOGP: Atomistic method implemented from | 0.41 |
Log Po/w (MLOGP)? MLOGP: Topological method implemented from | 7.04 |
Log Po/w (SILICOS-IT)? SILICOS-IT: Hybrid fragmental/topological method calculated by | 8.2 |
Consensus Log Po/w? Consensus Log Po/w: Average of all five predictions | 4.56 |
Log S (ESOL):? ESOL: Topological method implemented from | -8.39 |
Solubility | 0.00000234 mg/ml ; 0.0000000041 mol/l |
Class? Solubility class: Log S scale | Poorly soluble |
Log S (Ali)? Ali: Topological method implemented from | -8.81 |
Solubility | 0.000000892 mg/ml ; 0.0000000016 mol/l |
Class? Solubility class: Log S scale | Poorly soluble |
Log S (SILICOS-IT)? SILICOS-IT: Fragmental method calculated by | -12.54 |
Solubility | 0.0000000002 mg/ml ; 0.0 mol/l |
Class? Solubility class: Log S scale | Insoluble |
GI absorption? Gatrointestinal absorption: according to the white of the BOILED-Egg | High |
BBB permeant? BBB permeation: according to the yolk of the BOILED-Egg | No |
P-gp substrate? P-glycoprotein substrate: SVM model built on 1033 molecules (training set) | Yes |
CYP1A2 inhibitor? Cytochrome P450 1A2 inhibitor: SVM model built on 9145 molecules (training set) | No |
CYP2C19 inhibitor? Cytochrome P450 2C19 inhibitor: SVM model built on 9272 molecules (training set) | Yes |
CYP2C9 inhibitor? Cytochrome P450 2C9 inhibitor: SVM model built on 5940 molecules (training set) | Yes |
CYP2D6 inhibitor? Cytochrome P450 2D6 inhibitor: SVM model built on 3664 molecules (training set) | No |
CYP3A4 inhibitor? Cytochrome P450 3A4 inhibitor: SVM model built on 7518 molecules (training set) | No |
Log Kp (skin permeation)? Skin permeation: QSPR model implemented from | -4.72 cm/s |
Lipinski? Lipinski (Pfizer) filter: implemented from | 2.0 |
Ghose? Ghose filter: implemented from | None |
Veber? Veber (GSK) filter: implemented from | 0.0 |
Egan? Egan (Pharmacia) filter: implemented from | 0.0 |
Muegge? Muegge (Bayer) filter: implemented from | 2.0 |
Bioavailability Score? Abbott Bioavailability Score: Probability of F > 10% in rat | 0.17 |
PAINS? Pan Assay Interference Structures: implemented from | 0.0 alert |
Brenk? Structural Alert: implemented from | 0.0 alert: heavy_metal |
Leadlikeness? Leadlikeness: implemented from | No; 1 violation:MW<2.0 |
Synthetic accessibility? Synthetic accessibility score: from 1 (very easy) to 10 (very difficult) | 4.88 |
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
92.5% | With 1-Chloronaphthalene; In water; acetone; toluene; at 70 - 240℃; for 10h; | Synthesis Example 5 Synthesis of chloroaluminum phthalocyanine (A method described in Synthesis Example 1 of Japanese Patent Kokai Publication No. H9(1997) 217020) Phthalonitrile (180.0 g, (1.41 mol)), 900 ml of 1-chloronaphthalene and 47.0 g (0.353 mol) of aluminum (III) chloride were charged into a four-necked flask, and heated and stirred under reflux at 240C for 6 hours. Thereafter, the reflux was stopped and the mixture was allowed to cool to a temperature of approximately 130C, and thereafter was filtered under heating, sprinkled and washed with 1800 ml of hot toluene (100C), 80 ml of toluene and 900 ml of acetone, and substituted with 100 ml of toluene. The obtained cake was stirred and refluxed in 750 ml of toluene for 3 hours, thereafter filtered under heating at 100C, and thereafter was washed with 1800 ml of hot toluene (100C), 180 ml of toluene and 900 ml of acetone, and the solvent was substituted with 400 ml of water. The obtained cake was added to 4500 ml of water and heat-dispersed at 70C for 1 hour. After being filtered under heating, the obtained cake was washed with 900 ml of acetone and 1000 ml of water, and dried at 70C to obtain 187.6 g of chloroaluminum phthalocyanine ClAlPc (yield: 92.5%). |
92.5% | Synthesis Example 7 Synthesis of chloroaluminum phthalocyanine ClAlPc (A method described in Synthesis Example 1 of Japanese Patent Laid-Open Publication No. H9(1997) 217020) 180.0 g (1.41 mol) of phthalonitrile, 900 ml of 1-chloronaphthalene and 47.0 g (0.353 mol) of aluminum (III) chloride were charged into a four-necked flask, and heated and stirred under reflux at a temperature of 240C for 6 hours. Thereafter, the reflux was stopped and the mixture stood to cool to a temperature of approximately 130C, and thereafter was filtered under heating, sprinkled and washed with 1800 ml of hot toluene (100C), 80 ml of toluene and 900 ml of acetone, and substituted with 100 ml of toluene. The obtained cake was stirred and refluxed in 750 ml of toluene for 3 hours, thereafter filtered under heating at a temperature of 100C, and thereafter was washed with 1800 ml of hot toluene (100C), 180 ml of toluene and 900 ml of acetone, and the solvent was substituted with 400 ml of water. The obtained cake was added to 4500 ml of water and heat-dispersed at a temperature of 70C for 1 hour. After being filtered under heating, the obtained cake was washed with 900 ml of acetone and 1000 ml of water, and dried at a temperature of 70C to obtain 187.6 g of chloroaluminum phthalocyanine ClAlPc (yields 92.5%). | |
84.5% | at 200℃; for 15h; | Example 1 Comparative Method-No Ammonium Salt A chloroaluminum phthalocyanine pigment (Pigment 1) was prepared by adding 614.4 g phthalonitrile, 160.0 g anhydrous aluminum(III) chloride and 3248 g dichlorotoluenes (isomer mixture) to a 4 L glass kettle. The reaction mixture was stirred as the temperature was raised to 200 C. over a period of two hours and maintained for an additional 13 hours at 200 C. before cooling to room temperature. After cooling, the solvent was removed by vacuum distillation to obtain a crude phthalocyanine reaction product. The crude phthalocyanine reaction product was purified by preparing a slurry in 2.5 L of 1% aqueous sulfuric acid and heating to 90 C. for two hours with stirring, followed by filtration at 90 C., washing with water until the filtrate was neutralized, and drying at 80 C. to obtain 582.35 g (84.5%) of a purified reaction product. |
With 1,8-diazabicyclo[5.4.0]undec-7-ene; In pentan-1-ol; at 136℃; for 5h; | 225 parts of phthalodinitrile and 78 parts of aluminum chloride anhydride were added to 1250 parts of n-amyl alcohol in a reaction vessel and stirred. To this, 266 parts of DBU (1,8-Diazabicyclo [5.4.0] undec-7-ene) was added, the temperature was raised and refluxed at 136 C. for 5 hours. The reaction solution cooled to 30 C. with stirring was injected into a mixed solvent of 5000 parts of methanol and 10000 parts of water under stirring to obtain a blue slurry. The slurry was filtered, washed with a mixed solvent of 2000 parts of methanol and 4000 parts of water, and dried to obtain 135 parts of chloroaluminum phthalocyanine |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
84.8% | Concentrated sulfuric acid (176 g) was cooled to a temperature of 5C or less and a mixture of 2.9 g (0.005 mol) of <strong>[14154-42-8]chloroaluminum phthalocyanine</strong> and 2.9 g (0.005 mol) of titanylphthalocyanine was added thereto with keeping the temperature thereof, and was stirred at 5C for 2 hours. The mixture was dropped into 0.4L water and 0.8L of ice at 10C or less and dispersed for 2 hours. After standing for a while, the mixture was filtered under reduced pressure, and the obtained wet cake was sprinkled and washed with 2.0L of water. The wet cake and 0.7L of water were charged into a 2L beaker and dispersed at room temperature for 2 hours. After being filtered under reduced pressure, 1.5L of water was sprinkled on the obtained wet cake so as to wash. The wet cake, 0.2L of water and 0.15L of 25%-aqueous ammonia were charged into a 1L separable flask and dispersed at room temperature for 6 hours. After being filtered under reduced pressure, 1.5L of hot water and 1.5L of ion-exchanged water were sprinkled on the obtained wet cake so as to wash. The wet cake (30.4 g) was dried at 70C to obtain 4.8 g of blue solid represented by the following formula (yield: 84.8%). [] The results of elemental analysis of this compound (PcAl-O-TiPc, molecular weight: 1132.90) are shown in Table 4. [Table 4] CHNAlTiCalculated Value67.852.9419.782.384.23Found Value66.172.3918.352.244.90 An XRD spectrum of this compound is shown in Fig. 5. In addition, a mass spectrum of this compound by TOF-MS is shown in Fig. 6. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
89.8% | Concentrated sulfuric acid (352 g) was cooled to a temperature of 5C or less and a mixture of 5.8 g (0.010 mol) of <strong>[14154-42-8]chloroaluminum phthalocyanine</strong> and 5.8 g (0.010 mol) of vanadyl phthalocyanine was added thereto with keeping the temperature thereof, and was stirred at 5C for 2 hours. This mixture was dropped into 0..5L water and 1.5L of ice at 10C or less and dispersed for 2 hours. After standing for a while, the mixture was filtered under reduced pressure, and the obtained wet cake was sprinkled and washed with 1.0L of water. The wet cake and 1.4L of water were charged into a 3L beaker and dispersed at room temperature for 2 hours. The wet cake, 0.4L of water and 0.2L of 25%-aqueous ammonia were charged into a 1L separable flask and dispersed at room temperature for 6 hours. After being filtered under reduced pressure, 1.5L of hot water and 1.5L of ion-exchanged water were sprinkled on the obtained wet cake so as to wash. The wet cake was dried at 70C to obtain 10.2 g of blue solid represented by the following formula (yield: 89.8%). [] The results of elemental analysis of this compound (PcAl-O-VPc, molecular weight: 1135.98) are shown in Table 5. [Table 5] CHNAlVCalculated Value67.672.9319.732.384.48Found Value69.432.4919.142.204.58 |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
95% | Concentrated sulfuric acid (357 g) was cooled by ice-methanol to a temperature of 5C or less and a mixture of 6.17 g (0.01 mol) of chlorogallium phthalocyanine obtained in Synthesis Example 4 and 5.75 g (0. 01 mol) of <strong>[14154-42-8]chloroaluminum phthalocyanine</strong> obtained in Synthesis Example 5 was added with keeping the temperature thereof, and was stirred at 5C or less for 2 hours. This was poured onto 1400 g of ice/600 ml of water while being stirred at 10C or less, and further dispersed for 1 hour after the pouring was completed. After standing for a while, the supernatant was removed and filtered. The cake was washed with 2000 ml of water, and dispersed into 1800 ml of water and suction-filtered. The cake was washed with 800 ml of water. The water-washed cake was added to 550 ml of hot water and 66 ml of 25%-aqueous ammonia and dispersed under reflux for 6 hours. After being filtered, the cake was washed with 600 ml of hot water (60C) and 1650 ml of ion exchange water (IEW). When pH and conductivity of the filtrate are an equal level to those of the ion exchange water, the cake was dried at 70C to obtain 10.5 g of blue solid (yield: 89.8%). Then, 9.0 g of the obtained blue solid and 150 ml of o-dichlorobenzene were charged into a 300 ml flask, and the obtained mixture was stirred at 170 to 180C. This mixture was refluxed and stirred for 10 hours with removing water to be produced. After being filtered under heating at 130C, the obtained wet cake was sprinkled and washed sequentially with 225 ml of hot DMF (110C), 45 ml of DMF, 90 ml of methanol and 225 ml of IEW, thereafter the obtained cake was dried at 70C to obtain 8.4 g (yield: 95%) of a solid including a mu-oxo aluminum/gallium phthalocyanine dimer (PcAl-O-GaPc) in a form of mixed polymorph. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
74.5% | at 200℃; for 12h; | Example 6 Synthesis of Chloroaluminum Phthalocyanine Pigments Using Ammonium Acetate Without the Use of a Heavy Metal Catalyst A chloroaluminum phthalocyanine pigment (Pigment 6) was synthesized using equal molar ratios of an ammonium salt, ammonium acetate (CH3COONH4), and aluminum(III) chloride (AlCl3), without using a heavy metal catalyst, according to the following procedure. 76.80 g phthalonitrile, 20.00 g anhydrous aluminum(III) chloride, 11.79 g ammonium acetate and 406.0 g dichlorotoluenes (isomer mixture) were added to a 1 L glass kettle. The reaction mixture was stirred as the temperature was raised to 200 C. over a period of one hour and maintained for a total of 11 hours at 200 C. before cooling to room temperature. After cooling, the solvent was removed by vacuum distillation to obtain a crude phthalocyanine reaction product. The crude phthalocyanine reaction product was purified by preparing a slurry in 2.5 L of 1% aqueous sulfuric acid and heating to 90 C. for two hours with stirring, followed by filtration at 90 C., washing with water until the filtrate was neutralized, and drying at 80 C. to obtain 64.21 g (74.5%) of a purified reaction product. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
99.26% | With ammonium molybdate; at 200℃; for 12h; | Example 2 Comparative Method-No Ammonium Salt A chloroaluminum phthalocyanine pigment (Pigment 2) was prepared by adding 153.6 g phthalonitrile, 40.00 g anhydrous aluminum(III) chloride, 32.00 g urea, 1.20 g ammonium dimolybdate and 812.0 g dichlorotoluenes (isomer mixture) to a 1 L glass kettle. The reaction mixture was stirred as the temperature was raised to 200 C. over a period of three hours and maintained for a total of nine hours at 200 C. before cooling to room temperature. After cooling, the solvent was removed by vacuum distillation to obtain a crude phthalocyanine reaction product. The crude phthalocyanine reaction product was purified by preparing a slurry in 1% aqueous sulfuric acid and heating to 90 C. for two hours with stirring, followed by filtration at 90 C., washing with water until the filtrate was neutralized, and drying at 80 C. to obtain a 99.26% yield of a purified reaction product. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
85.37% | at 200℃; for 10.75h; | Example 3 Comparative Method-No Ammonium Salt A chloroaluminum phthalocyanine pigment (Pigment 3) was prepared by adding 76.8 g phthalonitrile, 20.00 g anhydrous aluminum(III) chloride and 406.0 g dichlorotoluenes (isomer mixture) to a 1 L glass kettle. The reaction mixture was stirred as ammonia gas was bubbled beneath the reaction surface as the temperature was raised to 200 C. over a period of 1.25 hours. Ammonia gas was continuously bubbled into the reaction mixture over the next two hours while the temperature was maintained at 200 C. After the bubbling of ammonia gas was discontinued, the reaction mixture was maintained at 200 C. for an additional 7.5 hours (10.75 hours at 200 C. total) before cooling to room temperature. After cooling, the solvent was removed by vacuum distillation to obtain a crude phthalocyanine reaction product. The crude phthalocyanine reaction product was purified by preparing a slurry in 2.5 L of 1% aqueous sulfuric acid and heating to 90 C. for two hours with stirring, followed by filtration at 90 C., washing with water until the filtrate was neutralized, and drying at 80 C. to obtain 73.57 g (85.37%) of a purified reaction product. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
at 200℃; for 10.5h; | Example 4 Synthesis of Chloroaluminum Phthalocyanine Pigments Using Ammonium Chloride Without the Use of a Heavy Metal Catalyst Several chloroaluminum phthalocyanine pigments were synthesized using varying molar ratios of ammonium chloride (NH4Cl) and aluminum(III) chloride (AlCl3) without using a heavy metal catalyst. Pigments 4A-4E were synthesized using 0.45:1, 0.9:1, 1:1, 1.8:1 and 3.6:1 molar equivalents of ammonium chloride to 53 aluminum(III) chloride, respectively, according to the following general procedure. Phthalonitrile, anhydrous aluminum(III) chloride, ammonium chloride and dichlorotoluenes (isomer mixture) were added to a 1 L glass kettle. The reaction mixture was stirred as the temperature was raised to 200 C. over a period of 1-1.5 hours and maintained for a total of 10.5 to 17 hours at 200 C. before cooling to room temperature. After cooling, the solvent was removed by vacuum distillation to obtain a crude phthalocyanine reaction product. The crude phthalocyanine reaction product was purified by preparing a slurry in 2.5 L of 1% aqueous sulfuric acid and heating to 90 C. for two hours with stirring, followed by filtration at 90 C., washing with water until the filtrate was neutralized, and drying at 80 C. to obtain a purified reaction product. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
89.11 g | at 200℃; for 12h; | Example 5 Synthesis of Chloroaluminum Phthalocyanine Pigments Using Ammonium Sulfate Without the Use of a Heavy Metal Catalyst A chloroaluminum phthalocyanine pigment (Pigment 5) was synthesized using equal molar ratios of ammonium sulfate ((NH4)2SO4) and aluminum(III) chloride (AlCl3), without using a heavy metal catalyst, according to the following procedure. 76.80 g phthalonitrile, 20.00 g anhydrous aluminum(III) chloride, 19.80 g ammonium sulfate and 406.0 g dichlorotoluenes (isomer mixture) were added to a 1 L glass kettle. The reaction mixture was stirred as the temperature was raised to 200 C. over a period of two hours and maintained for a total of 10 hours at 200 C. before cooling to room temperature. After cooling, the solvent was removed by vacuum distillation to obtain a crude phthalocyanine reaction product. The crude phthalocyanine reaction product was purified by preparing a slurry in 2.5 L of 1% aqueous sulfuric acid and heating to 90 C. for two hours with stirring, followed by filtration at 90 C., washing with water until the filtrate was neutralized, and drying at 80 C. to obtain 89.11 g (103%) of a purified reaction product. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
In toluene; at 115℃;Inert atmosphere; | General procedure: Prophetic Example For example a mixture of C1-AlPc (0.50 g, 0.87 mmol) and m-cresol (3.20 g, 29.63 mmol) could be added to 25 mL of Toluene in an oven dried and degassed 100 ml glass reactor. The reaction mixture could be heated to 115 C. overnight under ultra-pure N2 gas. The crude product will be cooled to room temperature prior to being washed by basic aqueous solution (2M KOH) to remove excess phenol and dried under vacuum. In some cases the functionalized Pc can be washed with isopropanol (optionally ultrasonicated) and filtered to remove excess phenol. The resulting product will be characterized by 1H NMR spectroscopy (DMSO) and DART mass spectroscopy. Using similar conditions, m-cresol derivatives of AlPc, GaPc, InPc, (Scheme 1) could be synthesized in chlorobenzene and toluene. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
at 20 - 40℃; for 3h; | Subsequently, 100 parts of <strong>[14154-42-8]chloroaluminum phthalocyanine</strong> was slowly added to 1,200 parts of concentrated sulfuric acid at room temperature in a reaction vessel. After stirring at 40 C for 3 hours, a sulfuric acid solution was poured into 24000 parts of cold water at 3 C. The blue precipitate was filtered, washed with water and dried to obtain 92 parts of a compound represented by the following general formula (2) Thereby obtaining a phthalocyanine compound (PB-1). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With ammonium molybdate; at 175 - 180℃; for 4h; | Phthalic anhydride 59.2 g (0.4 mol), urea 102 g (1.7 mol),13.34 g (0.1 mol) of aluminum chloride,6.2 g (0.005 mol) of ammonium molybdate are charged into a 1 liter three-necked round bottom flask and stirred under alkylbenzene or solventless,After heating, the mixture is reacted at 175 to 180 C for 4 hours.Phthalic anhydride is phthalic anhydride when water is mixed Reactivity is significantly reduced as it is hydrolyzed, and it is assumed that it is used under anhydrous conditions.Urea used a commonly used product.After cooling to room temperature, the reactant was dispersed in 1 liter of ethanol and filtered, and then, 5 liter three-necked flask was charged with 2 liters of 2.5 wt% hydrochloric acid solution, and the wet cake obtained by filtration was redispersed again, stirred for 3 hours, and filtered. .After filtration, the wet cake was washed with 1 wt% of 50 C caustic soda solution and treated until the filtrate was neutralized and neutral. Next, rinse with plenty of pH 7 distilled water of 15-20 . Then, the obtained wet cake was dried in an oven dryer to obtain aluminum chloride phthalocyanine.Elemental analysis and ICP of the compounds thus obtainedThe measurement results are listed in Table 1 below.Purity was analyzed as 99.37% |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With sodium hydroxide; In acetone; at 50℃; for 4h; | Example 2: Synthesis of Hydroxy Aluminum Phthalocyanine20 g (0.34 mol) of the aluminum chloride phthalocyanine compound of Example 1,200 ml of acetone and 20 ml of distilled water were added to a 1 liter three-necked round bottom flask, followed by stirring.It is hydrolyzed at 50 C. for 4 hours with sodium hydroxide as a catalyst and filtered.After filtration, wash the wet cake with distilled water until the filtrate is neutral. Then, the obtained wet cake was dried in an oven dryer to obtain hydroxy aluminum phthalocyanine.The elemental analysis and ICP measurement results of the compound thus obtained are shown in Table 2 below, and the overall purity was analyzed to be 99.15%. |
Tags: 14154-42-8 synthesis path| 14154-42-8 SDS| 14154-42-8 COA| 14154-42-8 purity| 14154-42-8 application| 14154-42-8 NMR| 14154-42-8 COA| 14154-42-8 structure
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P302 + P334 | IF ON SKIN: Immerse in cool water/wrap in wet bandages. |
P302 + P350 | IF ON SKIN: Gently wash with plenty of soap and water. |
P303 + P361 + P353 | IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. |
P304 + P312 | IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell. |
P304 + P340 | IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. |
P304 + P341 | IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing. |
P305 + P351 + P338 | IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. |
P306 + P360 | IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes. |
P307 + P311 | IF exposed: call a POISON CENTER or doctor/physician. |
P308 + P313 | IF exposed or concerned: Get medical advice/attention. |
P309 + P311 | IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician. |
P332 + P313 | IF SKIN irritation occurs: Get medical advice/attention. |
P333 + P313 | IF SKIN irritation or rash occurs: Get medical advice/attention. |
P335 + P334 | Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages. |
P337 + P313 | IF eye irritation persists: Get medical advice/attention. |
P342 + P311 | IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician. |
P370 + P376 | In case of fire: Stop leak if safe to Do so. |
P370 + P378 | In case of fire: |
P370 + P380 | In case of fire: Evacuate area. |
P370 + P380 + P375 | In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion. |
P371 + P380 + P375 | In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion. |
Storage | |
Code | Phrase |
P401 | |
P402 | Store in a dry place. |
P403 | Store in a well-ventilated place. |
P404 | Store in a closed container. |
P405 | Store locked up. |
P406 | Store in corrosive resistant/ container with a resistant inner liner. |
P407 | Maintain air gap between stacks/pallets. |
P410 | Protect from sunlight. |
P411 | |
P412 | Do not expose to temperatures exceeding 50 oC/ 122 oF. |
P413 | |
P420 | Store away from other materials. |
P422 | |
P402 + P404 | Store in a dry place. Store in a closed container. |
P403 + P233 | Store in a well-ventilated place. Keep container tightly closed. |
P403 + P235 | Store in a well-ventilated place. Keep cool. |
P410 + P403 | Protect from sunlight. Store in a well-ventilated place. |
P410 + P412 | Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF. |
P411 + P235 | Keep cool. |
Disposal | |
Code | Phrase |
P501 | Dispose of contents/container to ... |
P502 | Refer to manufacturer/supplier for information on recovery/recycling |
Physical hazards | |
Code | Phrase |
H200 | Unstable explosive |
H201 | Explosive; mass explosion hazard |
H202 | Explosive; severe projection hazard |
H203 | Explosive; fire, blast or projection hazard |
H204 | Fire or projection hazard |
H205 | May mass explode in fire |
H220 | Extremely flammable gas |
H221 | Flammable gas |
H222 | Extremely flammable aerosol |
H223 | Flammable aerosol |
H224 | Extremely flammable liquid and vapour |
H225 | Highly flammable liquid and vapour |
H226 | Flammable liquid and vapour |
H227 | Combustible liquid |
H228 | Flammable solid |
H229 | Pressurized container: may burst if heated |
H230 | May react explosively even in the absence of air |
H231 | May react explosively even in the absence of air at elevated pressure and/or temperature |
H240 | Heating may cause an explosion |
H241 | Heating may cause a fire or explosion |
H242 | Heating may cause a fire |
H250 | Catches fire spontaneously if exposed to air |
H251 | Self-heating; may catch fire |
H252 | Self-heating in large quantities; may catch fire |
H260 | In contact with water releases flammable gases which may ignite spontaneously |
H261 | In contact with water releases flammable gas |
H270 | May cause or intensify fire; oxidizer |
H271 | May cause fire or explosion; strong oxidizer |
H272 | May intensify fire; oxidizer |
H280 | Contains gas under pressure; may explode if heated |
H281 | Contains refrigerated gas; may cause cryogenic burns or injury |
H290 | May be corrosive to metals |
Health hazards | |
Code | Phrase |
H300 | Fatal if swallowed |
H301 | Toxic if swallowed |
H302 | Harmful if swallowed |
H303 | May be harmful if swallowed |
H304 | May be fatal if swallowed and enters airways |
H305 | May be harmful if swallowed and enters airways |
H310 | Fatal in contact with skin |
H311 | Toxic in contact with skin |
H312 | Harmful in contact with skin |
H313 | May be harmful in contact with skin |
H314 | Causes severe skin burns and eye damage |
H315 | Causes skin irritation |
H316 | Causes mild skin irritation |
H317 | May cause an allergic skin reaction |
H318 | Causes serious eye damage |
H319 | Causes serious eye irritation |
H320 | Causes eye irritation |
H330 | Fatal if inhaled |
H331 | Toxic if inhaled |
H332 | Harmful if inhaled |
H333 | May be harmful if inhaled |
H334 | May cause allergy or asthma symptoms or breathing difficulties if inhaled |
H335 | May cause respiratory irritation |
H336 | May cause drowsiness or dizziness |
H340 | May cause genetic defects |
H341 | Suspected of causing genetic defects |
H350 | May cause cancer |
H351 | Suspected of causing cancer |
H360 | May damage fertility or the unborn child |
H361 | Suspected of damaging fertility or the unborn child |
H361d | Suspected of damaging the unborn child |
H362 | May cause harm to breast-fed children |
H370 | Causes damage to organs |
H371 | May cause damage to organs |
H372 | Causes damage to organs through prolonged or repeated exposure |
H373 | May cause damage to organs through prolonged or repeated exposure |
Environmental hazards | |
Code | Phrase |
H400 | Very toxic to aquatic life |
H401 | Toxic to aquatic life |
H402 | Harmful to aquatic life |
H410 | Very toxic to aquatic life with long-lasting effects |
H411 | Toxic to aquatic life with long-lasting effects |
H412 | Harmful to aquatic life with long-lasting effects |
H413 | May cause long-lasting harmful effects to aquatic life |
H420 | Harms public health and the environment by destroying ozone in the upper atmosphere |
Sorry,this product has been discontinued.
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