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Chemical Structure| 141-46-8 Chemical Structure| 141-46-8

Structure of 141-46-8

Chemical Structure| 141-46-8

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Product Details of [ 141-46-8 ]

CAS No. :141-46-8
Formula : C2H4O2
M.W : 60.05
SMILES Code : OCC=O
MDL No. :MFCD00038088
InChI Key :WGCNASOHLSPBMP-UHFFFAOYSA-N
Pubchem ID :756

Safety of [ 141-46-8 ]

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H315-H319-H225
Precautionary Statements:P501-P240-P210-P233-P243-P241-P242-P264-P280-P370+P378-P337+P313-P305+P351+P338-P362+P364-P303+P361+P353-P332+P313-P403+P235
Class:3
UN#:1993
Packing Group:

Application In Synthesis of [ 141-46-8 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 141-46-8 ]

[ 141-46-8 ] Synthesis Path-Downstream   1~14

  • 2
  • [ 646-06-0 ]
  • [ 50-00-0 ]
  • [ 5694-68-8 ]
  • [ 628-35-3 ]
  • [ 31144-13-5 ]
  • [ 39239-93-5 ]
  • [ 107-21-1 ]
  • [ 141-46-8 ]
  • 3
  • [ 69-65-8 ]
  • [ 110-00-9 ]
  • [ 75-07-0 ]
  • [ 141-46-8 ]
  • [ 5077-67-8 ]
  • [ 116-09-6 ]
  • [ 431-03-8 ]
  • 4
  • [ 50-70-4 ]
  • [ 110-00-9 ]
  • [ 75-07-0 ]
  • [ 141-46-8 ]
  • [ 5077-67-8 ]
  • [ 116-09-6 ]
  • [ 431-03-8 ]
  • 5
  • [ 87-99-0 ]
  • [ 110-00-9 ]
  • [ 600-14-6 ]
  • [ 75-07-0 ]
  • [ 141-46-8 ]
  • [ 5077-67-8 ]
  • [ 116-09-6 ]
  • 6
  • [ 7647-01-0 ]
  • [ 7732-18-5 ]
  • [ 621-63-6 ]
  • [ 64-17-5 ]
  • [ 141-46-8 ]
  • 7
  • [ 216019-28-2 ]
  • [ 141-46-8 ]
  • [ 57260-71-6 ]
  • 4-[2-hydroxy-1-(3-isopropyl-phenyl)-ethyl]-piperazine-1-carboxylic acid <i>tert</i>-butyl ester [ No CAS ]
  • 8
  • [ 584-03-2 ]
  • [ 86943-35-3 ]
  • [ 141-46-8 ]
  • [ 5077-67-8 ]
  • 9
  • [ 141-46-8 ]
  • [ 149-32-6 ]
  • [ 50-70-4 ]
  • 10
  • [ 107-21-1 ]
  • [ 141-46-8 ]
  • [ 5694-68-8 ]
YieldReaction ConditionsOperation in experiment
With hydrogenchloride; In water; at 20℃; for 1h; In a four necked round-bottomed glass reactor, equipped with magnetic stirrer, thermometer, condenser maintained at -75°C (dry ice-lsopropyl alcohol) and two addition funnels, 60 g of glycol aldehyde (1.0 mol) and 62 g of ethylene glycol (1.0 mol) were loaded, followed by 10 g of 37percent HCI water solution (0.10 mol HCI) at room temperature; after 1 hour under stirring, the formation of cyclic acetal (G) was complete; the reactor was thus cooled to 0°C with an ice water bath, then a solution of 44 g (1.1 mol) of NaOH (s) and 44 ml of distilled water H2O was added in half an hour. After a slight exothermicity, at 0°C, 216 g (1.0 mmol) of (A) were slowly added. At the end of the addition, the reaction mixture was allowed to reach 20°C, and stirred for another 2 hours. The crude mixture was extracted three times with tetrahydrofuran (THF). The combined THF extracts were dehydrated with MgSO4, filtered and fractionally distilled, collecting 247 g of the partially hydrogenated ether (H) (yield 77percent mol). The aldehyde group of adduct (H) was deprotected (quantitatively) obtaining the corresponding aldehyde (J) by hydrolysis in acidic conditions (diluted HCI).
  • 11
  • [ 141-46-8 ]
  • [ 5077-67-8 ]
  • [ 1187452-09-0 ]
  • [ 72599-80-5 ]
  • 12
  • [ 50-00-0 ]
  • [ 141-46-8 ]
  • [ 453-17-8 ]
  • [ 497-09-6 ]
  • 13
  • [ 50-00-0 ]
  • [ 141-46-8 ]
  • [ 5077-67-8 ]
  • 1,2-dideoxy-L-xylo-hept-3-ulose-7-phosphate [ No CAS ]
  • 1,2-dideoxy-L-β-xylo-hept-3-ulose-7-phosphate [ No CAS ]
  • 14
  • [ 96-26-4 ]
  • [ 69816-37-1 ]
  • [ 141-46-8 ]
  • [ 5521-58-4 ]
  • 2-(5-aminopyrazin-2-yl)ethanol [ No CAS ]
YieldReaction ConditionsOperation in experiment
With sodium hydroxide; In aq. phosphate buffer; at 85℃; for 24h;pH 7.4; Pyrazine derivatives were synthesized from a one-pot reaction, in which 1,3-dihydroxyacetone, glycolaldehyde, and 2-aminoacetamidine-dihydrobromide (0.10 M 1:1:1 ratio) were mixed in aqueous solution with sodium phosphate (0.25 M) atpH 7.4 by addition of NaOH, then heated to 85 C for 24 h. In a2-mL microvial, reaction contents were de-aerated and purged with nitrogen before being sealed under vacuum. A 1.0 mL aliquot of the product mixture was diluted with 8 mL of water,and a 5 mL portion was then desalted on a 20 mL Discovery DSC-18 column (Supelco, Bellefonte, PA, USA). Material was eluted with 36 mL water and 44 mL 50% methanol/water, collected in 20 separate fractions. Salt-free fractions 10-20(from 37-80 mL eluent) were combined and concentrated to 0.5 mL syrup using a CentriVap centrifuge. After storage at -20 C, the mixture was suspended in 200 μL water, and 50 μL aliquots were further diluted in 300 μL water for adequate ampoule sampling volume.
 

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