There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.
Type | HazMat fee for 500 gram (Estimated) |
Excepted Quantity | USD 0.00 |
Limited Quantity | USD 15-60 |
Inaccessible (Haz class 6.1), Domestic | USD 80+ |
Inaccessible (Haz class 6.1), International | USD 150+ |
Accessible (Haz class 3, 4, 5 or 8), Domestic | USD 100+ |
Accessible (Haz class 3, 4, 5 or 8), International | USD 200+ |
Structure of 141-46-8
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The BI-3802 was designed by Boehringer Ingelheim and could be obtained free of charge through the Boehringer Ingelheim open innovation portal opnMe.com, associated with its negative control.
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Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.
Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.
Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.
Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.
Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.
CAS No. : | 141-46-8 |
Formula : | C2H4O2 |
M.W : | 60.05 |
SMILES Code : | OCC=O |
MDL No. : | MFCD00038088 |
InChI Key : | WGCNASOHLSPBMP-UHFFFAOYSA-N |
Pubchem ID : | 756 |
GHS Pictogram: |
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Signal Word: | Danger |
Hazard Statements: | H315-H319-H225 |
Precautionary Statements: | P501-P240-P210-P233-P243-P241-P242-P264-P280-P370+P378-P337+P313-P305+P351+P338-P362+P364-P303+P361+P353-P332+P313-P403+P235 |
Class: | 3 |
UN#: | 1993 |
Packing Group: | Ⅲ |
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With hydrogenchloride; In water; at 20℃; for 1h; | In a four necked round-bottomed glass reactor, equipped with magnetic stirrer, thermometer, condenser maintained at -75°C (dry ice-lsopropyl alcohol) and two addition funnels, 60 g of glycol aldehyde (1.0 mol) and 62 g of ethylene glycol (1.0 mol) were loaded, followed by 10 g of 37percent HCI water solution (0.10 mol HCI) at room temperature; after 1 hour under stirring, the formation of cyclic acetal (G) was complete; the reactor was thus cooled to 0°C with an ice water bath, then a solution of 44 g (1.1 mol) of NaOH (s) and 44 ml of distilled water H2O was added in half an hour. After a slight exothermicity, at 0°C, 216 g (1.0 mmol) of (A) were slowly added. At the end of the addition, the reaction mixture was allowed to reach 20°C, and stirred for another 2 hours. The crude mixture was extracted three times with tetrahydrofuran (THF). The combined THF extracts were dehydrated with MgSO4, filtered and fractionally distilled, collecting 247 g of the partially hydrogenated ether (H) (yield 77percent mol). The aldehyde group of adduct (H) was deprotected (quantitatively) obtaining the corresponding aldehyde (J) by hydrolysis in acidic conditions (diluted HCI). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With sodium hydroxide; In aq. phosphate buffer; at 85℃; for 24h;pH 7.4; | Pyrazine derivatives were synthesized from a one-pot reaction, in which 1,3-dihydroxyacetone, glycolaldehyde, and 2-aminoacetamidine-dihydrobromide (0.10 M 1:1:1 ratio) were mixed in aqueous solution with sodium phosphate (0.25 M) atpH 7.4 by addition of NaOH, then heated to 85 C for 24 h. In a2-mL microvial, reaction contents were de-aerated and purged with nitrogen before being sealed under vacuum. A 1.0 mL aliquot of the product mixture was diluted with 8 mL of water,and a 5 mL portion was then desalted on a 20 mL Discovery DSC-18 column (Supelco, Bellefonte, PA, USA). Material was eluted with 36 mL water and 44 mL 50% methanol/water, collected in 20 separate fractions. Salt-free fractions 10-20(from 37-80 mL eluent) were combined and concentrated to 0.5 mL syrup using a CentriVap centrifuge. After storage at -20 C, the mixture was suspended in 200 μL water, and 50 μL aliquots were further diluted in 300 μL water for adequate ampoule sampling volume. |