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Chemical Structure| 1383474-84-7 Chemical Structure| 1383474-84-7

Structure of 1383474-84-7

Chemical Structure| 1383474-84-7

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Product Details of [ 1383474-84-7 ]

CAS No. :1383474-84-7
Formula : C10H10N2O3
M.W : 206.20
SMILES Code : O=C(C1=CN=C2C=C(O)C=CN21)OCC
MDL No. :MFCD29068833
InChI Key :BFHBQAYTRCOGTR-UHFFFAOYSA-N
Pubchem ID :67976370

Safety of [ 1383474-84-7 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H315-H319
Precautionary Statements:P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313

Application In Synthesis of [ 1383474-84-7 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1383474-84-7 ]

[ 1383474-84-7 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 33631-05-9 ]
  • [ 33142-21-1 ]
  • [ 1383474-84-7 ]
YieldReaction ConditionsOperation in experiment
In ethanol; benzene; for 10h;Reflux; Step A: Preparation of ethyl 7-hydroxyimidazo[l,2-alpyridine-3-carboxylate:2-Aminopyridin-4-ol (3 g, 27 mmol) was dissolved in ethanol (90 mL) in 250 mL round bottom flask. Ethyl 2-chloro-3-oxopropanoate (5% in benzene; 130 mL; Commercial solution from Toronto Research Chemicals Inc.) was added and the mixture refluxed for 10 hours. Reaction was concentrated and triturated with ethyl acetate before drying under high vacuum to give ethyl 7-hydroxyimidazo[l,2-a]pyridine-3-carboxylate as a beige solid (829 mg).
  • 2
  • [ 1383474-84-7 ]
  • [ 194152-05-1 ]
  • ethyl 7-((1,1-dioxidotetrahydro-2H-thiopyran-4-yl)oxy)imidazo[1,2-a]pyridine-3-carboxylate [ No CAS ]
YieldReaction ConditionsOperation in experiment
76% With tributylphosphine; 1,1'-azodicarbonyl-dipiperidine; In toluene; at 20 - 150℃; for 0.25h;Microwave irradiation; To a microwave vial containing ethyl 7-hydroxyimidazo[ 1 ,2-a]pyridine-3-carboxylate (50 mg, 0.24 mmol), <strong>[194152-05-1]4-hydroxytetrahydro-2H-thiopyran 1,1-dioxide</strong> (73 mg, 0.49 mmol), 1,1 ?-(azodicarbonyl)dipiperidine (184 mg, 0.73 mmol) were added toluene (3 mL) and tri-N-butylphosphine (0.18 mL, 0.73 mmol) at rt. The reaction was heated with microwave at 150 °C for 15 mm. The solvent was removed. The crude product waspurified by normal phase chromatography to provide Intermediate 155A (62 mg, 76percent) as a white solid. LC-MS(ESI) m/z: 339.0 [M+H].
 

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