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Chemical Structure| 137661-31-5 Chemical Structure| 137661-31-5

Structure of 137661-31-5

Chemical Structure| 137661-31-5

(R)-Quinuclidin-3-amine hydrochloride

CAS No.: 137661-31-5

4.5 *For Research Use Only !

Cat. No.: A717055 Purity: 95%

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Product Details of [ 137661-31-5 ]

CAS No. :137661-31-5
Formula : C7H15ClN2
M.W : 162.66
SMILES Code : Cl[H].N[C@H]1CN2CCC1CC2
MDL No. :MFCD16036190

Safety of [ 137661-31-5 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H317-H319
Precautionary Statements:P280-P305+P351+P338

Application In Synthesis of [ 137661-31-5 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 137661-31-5 ]

[ 137661-31-5 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 478148-62-8 ]
  • [ 137661-31-5 ]
  • [ 478149-53-0 ]
YieldReaction ConditionsOperation in experiment
66% With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In chloroform; at 20℃; for 16.0h; First Step Synthesis of N-(1-Azabicyclo[2.2.2]oct-3(R)-yl)furo[2,3-c]pyridine-5-carboxamide To a solution (10 mL) of <strong>[478148-62-8]furo[2,3-c]pyridine-5-carboxylic acid</strong> (0.16 g, 1.0 mmol) in chloroform, o-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate (0.57 g, 1.5 mmol), diisopropylethylamine (0.70 mL, 4.0 mmol), and (R)-quinuclidine-3-amine hydrochloride (0.20 g, 1.0 mmol) were added, and the resulting mixture was stirred at room temperature. Sixteen hours later, distilled water was added thereto, and the resultant was then extracted with chloroform. The organic layer was washed with brine, then dried over anhydrous sodium sulfate and concentrated. The obtained crude product was purified by silica gel column chromatography (amine silica gel DM1020, Fuji Silysia Chemical Ltd., chloroform alone to chloroform/methanol=98/2) to obtain the title compound (0.18 mg; 66%) as a colorless liquid. 1H-NMR (400 MHz, CDCl3) delta: 1.40-1.55 (1H, m), 1.65-1.74 (2H, m), 1.80-1.90 (1H, m), 2.02-2.06 (1H, m), 2.63-2.70 (1H, m), 2.75-3.00 (4H, m), 3.39-3.46 (1H, m), 4.12-4.20 (1H, m), 6.89-6.92 (1H, m), 7.80 (1H, d, J=2.0 Hz) 8.25-8.35 (1H, m), 8.46-8.49 (1H, m), 8.75-8.78 (1H, m).MS (ESI) [M+H]+272
  • 2
  • [ 478148-62-8 ]
  • [ 137661-31-5 ]
  • PHA-543,613 [ No CAS ]
 

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