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CAS No. : | 136663-23-5 |
Formula : | C10H9NO3 |
M.W : | 191.18 |
SMILES Code : | COC(=O)C1=CC2=C(C=C1)N=C(C)O2 |
MDL No. : | MFCD00113064 |
InChI Key : | CIGMBXJEQUHKPR-UHFFFAOYSA-N |
Pubchem ID : | 12157467 |
GHS Pictogram: | ![]() |
Signal Word: | Warning |
Hazard Statements: | H302-H315-H319-H335 |
Precautionary Statements: | P261-P305+P351+P338 |
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
97% | Stage #1: With sodium hydroxide In ethanol; water at 20℃; for 2 h; Stage #2: With hydrogenchloride In ethanol; water | Preparation Example K-2. 2-Methyl-benzoxazole-6-carboxylic acid To a solution of 2-methyl-benzoxazole-6-carboxylic acid methyl ester (301 mg, 1.57mmol) in ethanol (10mL) was added an aqueous solution of 2N sodium hydroxide (10mL), and the mixture was stirred for 2 hours at room temperature. 2N Hydrochloric acid was added to the reaction mixture to adjust the pH to 4, and the solution was extracted with ethyl acetate. The organic layer was washed with brine, dried over anhydrous sodium sulfate, then, evaporated in vacuo, and the title compound (270mg, 1.52mmol, 97percent) was obtained. This was used in the next reaction without purification. 1H-NMR Spectrum (DMSO-d6) δ (ppm): 2.64 (3H, s), 7.73 (1H, d, J=8.0Hz), 7.93(1 H, dd, J=1.2, 8.0Hz), 8.15 (1 H, d, J= 1.2Hz). |
97% | Stage #1: at 20℃; for 2 h; Stage #2: With hydrogenchloride In water | To a solution of 2-methyl-benzoxazole-6-carboxylic acid methyl ester (301 mg, 1.57mmol) in ethanol (10mL) was added an aqueous solution of 2N sodium hydroxide (10mL), and the mixture was stirred for 2 hours at room temperature. 2N Hydrochloric acid was added to the reaction mixture to adjust the pH to 4, and the solution was extracted with ethyl acetate. The organic layer was washed with brine, dried over anhydrous sodium sulfate, then, evaporated in vacuo, and the title compound (270mg, 1.52mmol, 97percent) was obtained. This was used in the next reaction without purification. 1H-NMR Spectrum (DMSO-d6) δ(ppm) : 2.64 (3H, s), 7.73 (1 H, d, J=8.0Hz), 7.93(1 H, dd, J=1.2, 8.0Hz), 8.15 (1 H, d, J= 1.2Hz). |
90% | With lithium hydroxide monohydrate; water In tetrahydrofuran for 2 h; | To methyl 2-methyl-1,3-benzoxazole-6-carboxylate (8) (12.2 g, 0.064 mol) in THF (300 mL)/H2O (100 mL) was added lithium hydroxide monohydrate (5.4 g, 0.128 mol), and the mixture was vigorously stirred. After 2 h the THF was removed under vacuum. The remaining aqueous phase was acidified with HOAc and exhaustively extracted with CH2Cl2. The pooled organic extract was dried (Na2SO4) and concentrated to give a beige solid (10.2 g, 90percent yield): mp 245–246 °C (lit.40 245–246 °C); TLC (SiO2, ethyl acetate/methanol (90:10), UV) single spot Rf 0.38. 1H NMR (300 MHz, DMSO); δ 2.66 (s, 3H, NCH3), 7.75 (d, J = 8.3 Hz, 1H, H-5), 7.96 (dd, J = 8.3, 1.4 Hz, 1H, H-4), 8.16 (d, J = 0.7 Hz, 1H, H-7), 13.12 (bs, 1H, OH). |
65% | Stage #1: With lithium hydroxide monohydrate; water In tetrahydrofuran; methanol at 25℃; for 2 h; Stage #2: With hydrogenchloride In tetrahydrofuran; methanol | To a solution of methyl 2-methylbenzo[d]oxazole-6-carboxylate (2.0 g, 10 mmol) in tetrahydrofuran/methanol/water (1: 1 : 1, 15 mL) was added lithium hydroxide hydrate (0.88 g, 21 mmol). The resulting mixture was stirred at 25 °C for 2 hours. On completion, the mixture was acidified with hydrochloric acid, resulting in formation of a solid. The solid was collected by filtration, washed with water and dried in vacuo to give compound B-130 (1.2 g, 65percent yield) as a white solid. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
In acetic acid; for 6.0h;Heating / reflux; | 11.0 g of methyl 4-amino-3-hydroxybenzoate (CAS No. 63435-16-5, purchased from Lancaster) was dissolved in xylene (220 ml)-tetrahydrofuran (110ml) at room temperature. To this solution, acetyl chloride (4.73 ml) was added and heated to reflux for 6 hours. The mixture was partitioned between 1N aqueous hydrochloric acid and ethyl acetate and the ethyl acetate layer was separated. The ethyl acetate layer was washed with saturated aqueous sodium chloride, and then dried with magnesium sulfate. The mixture was filtrated, and the filtrate was concentrated under reduced pressure. The obtained residue was passed through a silica gel flash chromato (ethyl acetate/heptane system) to obtain 10 g of methyl 4-acetamide-3-hydroxybenzoate crude product. To the crude product, acetic acid (250 ml) was added and heated to reflux for 6 hours, and the mixture was concentrated under reduced pressure. The residue was partitioned between ethyl acetate and saturated aqueous sodium hydrogen carbonate, and the ethyl acetate layer was separated. The ethyl acetate layer was dried with magnesium sulfate, filtrated through NH silica gel, and the filtrate was concentrated under reduced pressure to obtain 9.52 g of 2-methyl-6-benzoxazole carboxylic acid methyl ester. To the obtained 2-methyl-6-benzoxazole carboxylic acid methyl ester (9.52 g), ethanol (100 ml) and 2N aqueous sodium hydroxide (49.8 ml) were added and stirred at 60 C. for 30 minutes. The mixture was concentrated under reduced pressure and acidified with 5N aqueous hydrochloric acid. The precipitate was filtrated, washed with water, dried and then recrystallized with ethanol to obtain 4.62 g of the title compound (CAS No. 13452-14-7). The structure of the obtained title compound and results from NMR measurement were as follows. 1H NMR (CD3OD) δ (ppm): 2.67 (3H, s), 7.67 (1H, d, J=8 Hz), 8.05 (1H, dd, J=1+8 Hz), 8.19 (1H, d, J=1 Hz). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
100% | Step 2: 2-Methylbenzord1oxazole-6-carboxyric acid (139); [0742] A solution of compound 138 (920 mg, 4.815 mmol) in THF: MeOH (30 mL of a 1 :1 solution) was treated with a solution of potassium hydroxide (0.698 g, 17.86 mmol) in H2O (15 mL). The reaction mixture was stirred for 65 min at room temperature then quenched with INHCl (18 mL, 18.6 mmol) (final pH of 2.5), THF was removed under reduced pressure and the remaining aqueous solution was cooled to -78 0C and lyophilized to give compound 139 (940 mg, quantitative). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
99% | Example 13a; 4-Acetamido-7V-(2-amino-5-(thiophen-2-yl)phenyl)-3-hydroxybenzamide (140; )Step 1 : Methyl 2-methylbenzo[dloxazole-6-carboxylate (138); [0740] A solution of hydroxylamine 137 (0.805 g, 4.815 mmol) was dissolved in trimethyl orthoacetate (MeC(OMe)3) (10 mL, 78.55 mmol) was treated with TFA (0.6 mL, 7.8 mmol) then stirred at room temperature for 90 min. The reaction mixture was diluted with DCM, washed with saturated NaHCO3, brine, dried over MgSO4 and concentrated to give compound 138 (0.911 g, 99% yield).[0741] 1H NMR (DMSO-d6) δ (ppm): 8.19 (s, J= 0.98 Hz, IH), 7.95 (dd, J= 8.4, 1.6 Hz, IH),7.76 (d, J= 8.2 Hz, IH), 3.88 (s, 3H), 2.67 (s, 3H). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
97% | Preparation Example K-2. 2-Methyl-benzoxazole-6-carboxylic acid To a solution of <strong>[136663-23-5]2-methyl-benzoxazole-6-carboxylic acid methyl ester</strong> (301 mg, 1.57mmol) in ethanol (10mL) was added an aqueous solution of 2N sodium hydroxide (10mL), and the mixture was stirred for 2 hours at room temperature. 2N Hydrochloric acid was added to the reaction mixture to adjust the pH to 4, and the solution was extracted with ethyl acetate. The organic layer was washed with brine, dried over anhydrous sodium sulfate, then, evaporated in vacuo, and the title compound (270mg, 1.52mmol, 97%) was obtained. This was used in the next reaction without purification. 1H-NMR Spectrum (DMSO-d6) δ (ppm): 2.64 (3H, s), 7.73 (1H, d, J=8.0Hz), 7.93(1 H, dd, J=1.2, 8.0Hz), 8.15 (1 H, d, J= 1.2Hz). | |
97% | To a solution of <strong>[136663-23-5]2-methyl-benzoxazole-6-carboxylic acid methyl ester</strong> (301 mg, 1.57mmol) in ethanol (10mL) was added an aqueous solution of 2N sodium hydroxide (10mL), and the mixture was stirred for 2 hours at room temperature. 2N Hydrochloric acid was added to the reaction mixture to adjust the pH to 4, and the solution was extracted with ethyl acetate. The organic layer was washed with brine, dried over anhydrous sodium sulfate, then, evaporated in vacuo, and the title compound (270mg, 1.52mmol, 97%) was obtained. This was used in the next reaction without purification. 1H-NMR Spectrum (DMSO-d6) δ(ppm) : 2.64 (3H, s), 7.73 (1 H, d, J=8.0Hz), 7.93(1 H, dd, J=1.2, 8.0Hz), 8.15 (1 H, d, J= 1.2Hz). | |
90% | With lithium hydroxide monohydrate; water; In tetrahydrofuran; for 2.0h; | To <strong>[136663-23-5]methyl 2-methyl-1,3-benzoxazole-6-carboxylate</strong> (8) (12.2 g, 0.064 mol) in THF (300 mL)/H2O (100 mL) was added lithium hydroxide monohydrate (5.4 g, 0.128 mol), and the mixture was vigorously stirred. After 2 h the THF was removed under vacuum. The remaining aqueous phase was acidified with HOAc and exhaustively extracted with CH2Cl2. The pooled organic extract was dried (Na2SO4) and concentrated to give a beige solid (10.2 g, 90% yield): mp 245-246 C (lit.40 245-246 C); TLC (SiO2, ethyl acetate/methanol (90:10), UV) single spot Rf 0.38. 1H NMR (300 MHz, DMSO); δ 2.66 (s, 3H, NCH3), 7.75 (d, J = 8.3 Hz, 1H, H-5), 7.96 (dd, J = 8.3, 1.4 Hz, 1H, H-4), 8.16 (d, J = 0.7 Hz, 1H, H-7), 13.12 (bs, 1H, OH). |
65% | To a solution of <strong>[136663-23-5]methyl 2-methylbenzo[d]oxazole-6-carboxylate</strong> (2.0 g, 10 mmol) in tetrahydrofuran/methanol/water (1: 1 : 1, 15 mL) was added lithium hydroxide hydrate (0.88 g, 21 mmol). The resulting mixture was stirred at 25 C for 2 hours. On completion, the mixture was acidified with hydrochloric acid, resulting in formation of a solid. The solid was collected by filtration, washed with water and dried in vacuo to give compound B-130 (1.2 g, 65% yield) as a white solid. | |
11.0 g of methyl 4-amino-3-hydroxybenzoate (CAS No. 63435-16-5, purchased from Lancaster) was dissolved in xylene (220 ml)-tetrahydrofuran (110ml) at room temperature. To this solution, acetyl chloride (4.73 ml) was added and heated to reflux for 6 hours. The mixture was partitioned between 1N aqueous hydrochloric acid and ethyl acetate and the ethyl acetate layer was separated. The ethyl acetate layer was washed with saturated aqueous sodium chloride, and then dried with magnesium sulfate. The mixture was filtrated, and the filtrate was concentrated under reduced pressure. The obtained residue was passed through a silica gel flash chromato (ethyl acetate/heptane system) to obtain 10 g of methyl 4-acetamide-3-hydroxybenzoate crude product. To the crude product, acetic acid (250 ml) was added and heated to reflux for 6 hours, and the mixture was concentrated under reduced pressure. The residue was partitioned between ethyl acetate and saturated aqueous sodium hydrogen carbonate, and the ethyl acetate layer was separated. The ethyl acetate layer was dried with magnesium sulfate, filtrated through NH silica gel, and the filtrate was concentrated under reduced pressure to obtain 9.52 g of <strong>[136663-23-5]2-methyl-6-benzoxazole carboxylic acid methyl ester</strong>. To the obtained <strong>[136663-23-5]2-methyl-6-benzoxazole carboxylic acid methyl ester</strong> (9.52 g), ethanol (100 ml) and 2N aqueous sodium hydroxide (49.8 ml) were added and stirred at 60 C. for 30 minutes. The mixture was concentrated under reduced pressure and acidified with 5N aqueous hydrochloric acid. The precipitate was filtrated, washed with water, dried and then recrystallized with ethanol to obtain 4.62 g of the title compound (CAS No. 13452-14-7). The structure of the obtained title compound and results from NMR measurement were as follows. 1H NMR (CD3OD) δ (ppm): 2.67 (3H, s), 7.67 (1H, d, J=8 Hz), 8.05 (1H, dd, J=1+8 Hz), 8.19 (1H, d, J=1 Hz). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
72% | at 100℃; for 3.0h; | Example 59; 2-(2, 6-Dichloro-phenylimino)-5- (2-methyl-benzooxazol-6-yl-methylene)-thiazolidin-4-one; a) 2-Methvl-benzooxazole-6-carboxvlic acid methyl ester; A suspension of methyl 4-amino-3-hydroxy-benzoate (30 g, 0.18 mol) in triethylorthoacetate (90 mL) was heated to 100 oC for 3 hours. Ethanol (150 mL) was added followed by water (50 mL). The reaction mixture was filtered to yield 25 g (72 % yield) of pure 2-methyl-benzooxazole-6-carboxylic acid methyl ester. 1H-NMR (CDC13) : 5 2. 67 (s, 3H), 3.94 (s, 3H), 7.65 (d, 1H, J=8.1 Hz), 8.02 (dd, 1H, J=8.1 Hz, J'=1.5 Hz), 8.15 (d, 1H, J=1.5 Hz). LC MS (m/e) = 192.2 (MH+). Rt = 1.70 min |
72% | at 100℃; for 3.0h; | A suspension of methyl 4-amino-3-hydroxy-benzoate (30 g, 0.18 mol) in triethylorthoacetate (90 ml.) was heated to 100 0C for 3 hours. Ethanol (150 ml.) was added followed by water (50 ml_). The reaction mixture was filtered to yield 25 g (72 % yield) of pure 2-methyl-benzooxazole-6-carboxylic acid methyl ester. 1H- NMR (CDCI3): D2.67 (s, 3H), 3.94 (s, 3H), 7.65 (d, 1 H, J=8.1 Hz), 8.02 (dd, 1 H, J=8.1 Hz, J'=1.5 Hz), 8.15 (d, 1 H, J=1.5 Hz). LC MS (m/e) = 192.2 (MH+). Rt = 1.70 min |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
58% | With lithium aluminium tetrahydride; In tetrahydrofuran; at -20 - 20℃; | b) (2-Methyl-benzooxazol-6-vl)-methanol; To the solution of <strong>[136663-23-5]2-methyl-benzooxazole-6-carboxylic acid methyl ester</strong> (25 g, 0.13 mol) in THF (500 mL) at-20 oC was added a solution of lithium aluminum hydride (4.81 g, 130 mL of 1 M solution in THF, 0.13 mmol, 1 eq) and the reaction mixture was allowed to warm up to the room temperature overnight. Water (5 mL) followed by 1 M NaOH solution (5 mL) followed by water (15 mL) was added and the reaction mixture was stirred for 15 min at the room temperature. The suspension was filtered, liquid evaporated and purified by column chromatography (1: 3 ethyl acetate: dichloromethane) to give 12.5 g (58 % yield) of pure (2-methyl-benzooxazol-6-yl)-methanol. lH-NMR (CDCls) : õ 2.64 (s, 3H), 4.82 (s, 2H), 7.29 (d, 1H, J=8 Hz), 7. 53 (s, 1H), 7.62 (d, 1H, J=8 Hz). LC MS (m/e) = 164.2 (MH+). |
58% | To the solution of <strong>[136663-23-5]2-methyl-benzooxazole-6-carboxylic acid methyl ester</strong> (25 g, 0.13 mol) in THF (500 mL) at -20 0C was added a solution of lithium aluminum hydride (4.81 g, 130 mL of 1 M solution in THF, 0.13 mmol, 1 eq) and the reaction mixture was allowed to warm up to the room temperature overnight. Water (5 mL) followed by 1 M NaOH solution (5 mL) followed by water (15 mL) was added and the reaction mixture was stirred for 15 min at the room temperature. The suspension was filtered, liquid evaporated and purified by column chromatography (1 :3 ethyl acetate: dichloromethane) to give 12.5 g (58 % yield) of pure (2-methyl- benzooxazol-6-yl)-methanol. 1H-NMR (CDCI3): P2.64 (s, 3H), 4.82 (s, 2H), 7.29 (d, 1 H, J=8 Hz), 7.53 (s, 1 H), 7.62 (d, 1 H, J=8 Hz). LC MS (m/e) = 164.2 (MH+). Rt = 1.03 min. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
80.4% | With pyridinium p-toluenesulfonate; triethylamine; In xylene; for 8.5h;Heating / reflux; | Preparation Example K-1. 2-Methyl-benzoxazole-6-carboxylic acid methyl ester To a solution of 4-amino-3-hydroxy-benzoic acid methyl ester (2085mg, 12.47mmmol) in xylene (200mL) were added acetyl chloride (1.06mL, 14.96mmol), pyridinium p-toluenesulfonate (940mg, 3.74mmol) and triethylamine (2.09mL, 14.96mmol), and the solution was stirred for 8.5 hours under reflux. Ethyl acetate was added to the reaction mixture, which was then washed with water, dried over anhydrous magnesium sulfate, then, evaporated in vacuo, the resulting residue was purified by silica gel chromatography (hexane-ethyl acetate), and the title compound (1917mg, 10.02mmol, 80.4%) was obtained. 1H-NMR Spectrum (CDCl3) δ (ppm): 2.69 (3H, s), 3.96 (3H, s), 7.68 (1H, d, J=8.4Hz), 8.05 (1 H, dd, J=1.2, 8.4Hz), 8.17 (1 H, d, J= 1.2Hz). |
80.4% | With pyridinium p-toluenesulfonate; triethylamine; In xylene; for 8.5h;Heating / reflux; | To a solution of 4-amino-3-hydroxy-benzoic acid methyl ester (2085mg, 12.47mmmol) in xylene (200mL) were added acetyl chloride (1.06mL, 14.96mmol), pyridinium p-toluenesulfonate (940mg, 3.74mmol) and triethylamine (2.09mL, 14.96mmol), and the solution was stirred for 8.5 hours under reflux. Ethyl acetate was added to the reaction mixture, which was then washed with water, dried over anhydrous magnesium sulfate, then, evaporated in vacuo, the resulting residue was purified by silica gel chromatography (hexane-ethyl acetate), and the title compound (1917mg, 10.02mmol, 80.4%) was obtained. 1H-NMR Spectrum (CDCl3) δ(ppm): 2.69 (3H, s), 3.96 (3H, s), 7.68 (1H, d, J=8.4Hz), 8.05 (1 H, dd, J=1.2; 8.4Hz), 8.17 (1 H, d, J= 1.2Hz). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With sulfuric acid; In methanol; water; ethyl acetate; 3-hydroxy-4-aminobenzoic acid methyl ester; | a Methyl 2-methylbenzoxazole-6 carboxylate In a 50 ml round-bottomed three-necked flask equipped with a 12-inch Vigraux column and a Dean Stark trap assembly were placed methyl 4-amino-3-hydroxybenzoate (10.0 g, 60 mmole), trimethylorthoacetate (10.8 g, 90 mmole), and concentrated sulfuric acid (0.25 g, 2.6 mmole). The resulting well-stirred mixture was heated at 115 C. until approximately 8 ml of methanol were collected in the Dean Stark trap. The reaction mixture was heated at 160 C. for another 60 minutes. The reaction mixture was cooled to room temperature and dissolved in ethyl acetate. The resulting organic solution was extracted sequentially with saturated aqueous sodium bicarbonate (1*100 ml), water (2*50 ml), brine, and dried over anhydrous magnesium sulfate. The solvent was removed in the rotary evaporator yielding 7.1 g of the expected methyl 2-methylbenzoxazole-6 carboxylate used as such in the next step. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
99% | In methanol; at 20℃; | To methyl 4-amino-3-hydroxybenzoate (7a) (10.8 g, 0.065 mol) in MeOH (125 mL) was added dimethyl acetimidate hydrochloride (9.2 g, 0.084 mol), and the mixture was stirred overnight at room temperature with MeOH (30 mL) added to maintain fluidity. The solids (6.7 g) were collected by filtration, and the ML was concentrated. The residue was triturated with EtOAc affording additional solids (5.5 g). The tan solids were combined (12.2 g, 99% yield): mp 103-104 C (lit.39 103-104 C); TLC (SiO2, ethyl acetate/chloroform, methanol, concentrated ammonium hydroxide (90:8:1.8:0.2), UV) single spot Rf 0.76; MS MH+ 192.2. 1H NMR (300 MHz, CDCl3); δ 2.69 (s, 3H, NCH3), 3.96 (s, 3H, OCH3), 7.68 (d, J = 8.3 Hz, 1H, H-5), 8.05 (dd, J = 8.3, 1.5 Hz, 1H, H-4), 8.17 (d, J = 1 Hz, 1H, H-7). |
Tags: 136663-23-5 synthesis path| 136663-23-5 SDS| 136663-23-5 COA| 136663-23-5 purity| 136663-23-5 application| 136663-23-5 NMR| 136663-23-5 COA| 136663-23-5 structure
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P363 | Wash contaminated clothing before reuse. |
P370 | In case of fire: |
P371 | In case of major fire and large quantities: |
P372 | Explosion risk in case of fire. |
P373 | DO NOT fight fire when fire reaches explosives. |
P374 | Fight fire with normal precautions from a reasonable distance. |
P376 | Stop leak if safe to do so. Oxidising gases (section 2.4) 1 |
P377 | Leaking gas fire: Do not extinguish, unless leak can be stopped safely. |
P378 | |
P380 | Evacuate area. |
P381 | Eliminate all ignition sources if safe to do so. |
P390 | Absorb spillage to prevent material damage. |
P391 | Collect spillage. Hazardous to the aquatic environment |
P301 + P310 | IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. |
P301 + P312 | IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. |
P301 + P330 + P331 | IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. |
P302 + P334 | IF ON SKIN: Immerse in cool water/wrap in wet bandages. |
P302 + P350 | IF ON SKIN: Gently wash with plenty of soap and water. |
P303 + P361 + P353 | IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. |
P304 + P312 | IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell. |
P304 + P340 | IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. |
P304 + P341 | IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing. |
P305 + P351 + P338 | IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. |
P306 + P360 | IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes. |
P307 + P311 | IF exposed: call a POISON CENTER or doctor/physician. |
P308 + P313 | IF exposed or concerned: Get medical advice/attention. |
P309 + P311 | IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician. |
P332 + P313 | IF SKIN irritation occurs: Get medical advice/attention. |
P333 + P313 | IF SKIN irritation or rash occurs: Get medical advice/attention. |
P335 + P334 | Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages. |
P337 + P313 | IF eye irritation persists: Get medical advice/attention. |
P342 + P311 | IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician. |
P370 + P376 | In case of fire: Stop leak if safe to Do so. |
P370 + P378 | In case of fire: |
P370 + P380 | In case of fire: Evacuate area. |
P370 + P380 + P375 | In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion. |
P371 + P380 + P375 | In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion. |
Storage | |
Code | Phrase |
P401 | |
P402 | Store in a dry place. |
P403 | Store in a well-ventilated place. |
P404 | Store in a closed container. |
P405 | Store locked up. |
P406 | Store in corrosive resistant/ container with a resistant inner liner. |
P407 | Maintain air gap between stacks/pallets. |
P410 | Protect from sunlight. |
P411 | |
P412 | Do not expose to temperatures exceeding 50 oC/ 122 oF. |
P413 | |
P420 | Store away from other materials. |
P422 | |
P402 + P404 | Store in a dry place. Store in a closed container. |
P403 + P233 | Store in a well-ventilated place. Keep container tightly closed. |
P403 + P235 | Store in a well-ventilated place. Keep cool. |
P410 + P403 | Protect from sunlight. Store in a well-ventilated place. |
P410 + P412 | Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF. |
P411 + P235 | Keep cool. |
Disposal | |
Code | Phrase |
P501 | Dispose of contents/container to ... |
P502 | Refer to manufacturer/supplier for information on recovery/recycling |
Physical hazards | |
Code | Phrase |
H200 | Unstable explosive |
H201 | Explosive; mass explosion hazard |
H202 | Explosive; severe projection hazard |
H203 | Explosive; fire, blast or projection hazard |
H204 | Fire or projection hazard |
H205 | May mass explode in fire |
H220 | Extremely flammable gas |
H221 | Flammable gas |
H222 | Extremely flammable aerosol |
H223 | Flammable aerosol |
H224 | Extremely flammable liquid and vapour |
H225 | Highly flammable liquid and vapour |
H226 | Flammable liquid and vapour |
H227 | Combustible liquid |
H228 | Flammable solid |
H229 | Pressurized container: may burst if heated |
H230 | May react explosively even in the absence of air |
H231 | May react explosively even in the absence of air at elevated pressure and/or temperature |
H240 | Heating may cause an explosion |
H241 | Heating may cause a fire or explosion |
H242 | Heating may cause a fire |
H250 | Catches fire spontaneously if exposed to air |
H251 | Self-heating; may catch fire |
H252 | Self-heating in large quantities; may catch fire |
H260 | In contact with water releases flammable gases which may ignite spontaneously |
H261 | In contact with water releases flammable gas |
H270 | May cause or intensify fire; oxidizer |
H271 | May cause fire or explosion; strong oxidizer |
H272 | May intensify fire; oxidizer |
H280 | Contains gas under pressure; may explode if heated |
H281 | Contains refrigerated gas; may cause cryogenic burns or injury |
H290 | May be corrosive to metals |
Health hazards | |
Code | Phrase |
H300 | Fatal if swallowed |
H301 | Toxic if swallowed |
H302 | Harmful if swallowed |
H303 | May be harmful if swallowed |
H304 | May be fatal if swallowed and enters airways |
H305 | May be harmful if swallowed and enters airways |
H310 | Fatal in contact with skin |
H311 | Toxic in contact with skin |
H312 | Harmful in contact with skin |
H313 | May be harmful in contact with skin |
H314 | Causes severe skin burns and eye damage |
H315 | Causes skin irritation |
H316 | Causes mild skin irritation |
H317 | May cause an allergic skin reaction |
H318 | Causes serious eye damage |
H319 | Causes serious eye irritation |
H320 | Causes eye irritation |
H330 | Fatal if inhaled |
H331 | Toxic if inhaled |
H332 | Harmful if inhaled |
H333 | May be harmful if inhaled |
H334 | May cause allergy or asthma symptoms or breathing difficulties if inhaled |
H335 | May cause respiratory irritation |
H336 | May cause drowsiness or dizziness |
H340 | May cause genetic defects |
H341 | Suspected of causing genetic defects |
H350 | May cause cancer |
H351 | Suspected of causing cancer |
H360 | May damage fertility or the unborn child |
H361 | Suspected of damaging fertility or the unborn child |
H361d | Suspected of damaging the unborn child |
H362 | May cause harm to breast-fed children |
H370 | Causes damage to organs |
H371 | May cause damage to organs |
H372 | Causes damage to organs through prolonged or repeated exposure |
H373 | May cause damage to organs through prolonged or repeated exposure |
Environmental hazards | |
Code | Phrase |
H400 | Very toxic to aquatic life |
H401 | Toxic to aquatic life |
H402 | Harmful to aquatic life |
H410 | Very toxic to aquatic life with long-lasting effects |
H411 | Toxic to aquatic life with long-lasting effects |
H412 | Harmful to aquatic life with long-lasting effects |
H413 | May cause long-lasting harmful effects to aquatic life |
H420 | Harms public health and the environment by destroying ozone in the upper atmosphere |
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