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Chemical Structure| 135248-89-4 Chemical Structure| 135248-89-4
Chemical Structure| 135248-89-4

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Product Citations

Product Citations

Ritchey, Jeremy L ; Filippi, Lindsi ; Ballard, Davis ; Pei, Dehua ;

Abstract: Intracellular delivery of biological cargos, which would yield new research tools and novel therapeutics, remains an active area of research. A convenient and potentially general approach involves the conjugation of a cell-penetrating peptide to a cargo of interest. However, linear CPPs lack sufficient cytosolic entry efficiency and metabolic stability, while previous backbone cyclized CPPs have several drawbacks including the necessity for chemical synthesis and posttranslational conjugation to peptide/protein cargos and epimerization during cyclization. We report here a new class of bismuth cyclized CPPs with excellent cytosolic entry efficiencies, proteolytic stability, and potential compatibility with genetic encoding and recombinant production.

Keywords: bismuth ; cell-penetrating peptides ; drug delivery ; endosomal escape ; peptide cyclization

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Product Details of Fmoc-Cys-OH

CAS No. :135248-89-4
Formula : C18H17NO4S
M.W : 343.40
SMILES Code : O=C(O)[C@@H](NC(OCC1C2=C(C3=C1C=CC=C3)C=CC=C2)=O)CS
MDL No. :MFCD03788178
InChI Key :RMTDKXQYAKLQKF-INIZCTEOSA-N
Pubchem ID :11024349

Safety of Fmoc-Cys-OH

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Application In Synthesis of Fmoc-Cys-OH

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Upstream synthesis route of [ 135248-89-4 ]
  • Downstream synthetic route of [ 135248-89-4 ]

[ 135248-89-4 ] Synthesis Path-Upstream   1~2

  • 1
  • [ 135248-89-4 ]
  • [ 104-81-4 ]
  • [ 136050-67-4 ]
References: [1] Protein and Peptide Letters, 2014, vol. 21, # 12, p. 1257 - 1264.
  • 2
  • [ 91-01-0 ]
  • [ 135248-89-4 ]
  • [ 247595-29-5 ]
References: [1] Organic Letters, 2012, vol. 14, # 21, p. 5472 - 5475,4.
[2] Organic Letters, 2012, vol. 14, # 21, p. 5472 - 5475.
 

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