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Chemical Structure| 1335523-82-4 Chemical Structure| 1335523-82-4

Structure of 1335523-82-4

Chemical Structure| 1335523-82-4

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Product Details of [ 1335523-82-4 ]

CAS No. :1335523-82-4
Formula : C11H14BrN
M.W : 240.14
SMILES Code : BrC1=CC=C([C@H]2CNCCC2)C=C1
MDL No. :MFCD20451701

Safety of [ 1335523-82-4 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H315-H319-H335
Precautionary Statements:P261-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P332+P313-P337+P313-P362-P403+P233-P405-P501

Application In Synthesis of [ 1335523-82-4 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Upstream synthesis route of [ 1335523-82-4 ]
  • Downstream synthetic route of [ 1335523-82-4 ]

[ 1335523-82-4 ] Synthesis Path-Upstream   1~2

  • 1
  • [ 24424-99-5 ]
  • [ 1335523-82-4 ]
  • [ 1476776-55-2 ]
YieldReaction ConditionsOperation in experiment
99% With sodium hydroxide In water at 20 - 35℃; In a 500 mL eggplant-shaped flask,15 g (36.4 mmol) of compound (6) and 1.5 g (36.4 mmol) of sodium hydroxide were added,150ml and 50ml water,Boc anhydride 9.5 g (43.7 mmol) was added dropwise.Stir at room temperature overnightTLC showed complete reaction,Separate the organic layer,Sodium sulfate drying,It was concentrated by filtration to obtain 12.3 g of an oily compound (7).The yield is 99percent.98.1percent purity.
11.2 g With dmap; triethylamine In dichloromethane at 20℃; for 8 h; Example 7 Compound 8 (9.20 g, 0.038 mol) was added 60 mL of dichloromethane, di-tert-butyl dicarbonate (10.8 g, 0.05 mol), triethylamine (5.70 g, 0.057 mol), DMAP (0.460 g, 3.80 mmol) was reacted at room temperature for 8 hours. The reaction was washed with saturated sodium bicarbonate and dried over anhydrous sodium sulfate. The organic phase was evaporated to dryness to give 11.2 g of a pale yellow solid.
References: [1] Patent: CN107663190, 2018, A, . Location in patent: Paragraph 0075; 0076; 0077.
[2] Patent: CN106854176, 2017, A, . Location in patent: Paragraph 0046; 0047.
  • 2
  • [ 1335523-82-4 ]
  • [ 1476776-55-2 ]
References: [1] Organic Process Research and Development, 2014, vol. 18, # 1, p. 215 - 227.
 

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