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Chemical Structure| 131337-81-0 Chemical Structure| 131337-81-0

Structure of 131337-81-0

Chemical Structure| 131337-81-0

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Product Details of [ 131337-81-0 ]

CAS No. :131337-81-0
Formula : C8H7NOS
M.W : 165.21
SMILES Code : OCC1=CC2=CC=CN=C2S1
MDL No. :MFCD07772792
InChI Key :XLUKSWZEEAGBDH-UHFFFAOYSA-N
Pubchem ID :7162092

Safety of [ 131337-81-0 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P280-P301+P312-P302+P352-P305+P351+P338

Application In Synthesis of [ 131337-81-0 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 131337-81-0 ]

[ 131337-81-0 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 53174-98-4 ]
  • [ 131337-81-0 ]
YieldReaction ConditionsOperation in experiment
With sodium borohydrid; In ethanol; EXAMPLE N 2-Chloromethyl-thieno[2,3-b]pyridine Thieno[2,3-b]pyridine-2-carboxaldehyde (1.63 g) prepared according to J. Het. Chem. 355 (1974) was dissolved in ethanol (20 ml) and to the solution was added sodium borohydride (0.19 g). After 30 minutes the solution was evaporated to dryness and the residue extracted with methylene chloride (50 ml). The organic extract was washed with water (2*25 ml), the extract dried and then evaporated to obtain 2-hydroxymethylthieno[2,3-b]pyridine (1.40 g) as an amber oil. 'H-NMR (CDCl3,60 MHz): 4.9 (s, 1H), 6.3 (s, 1H), 6.9 s, 1H), 7.1 (m, 1H), 7.8 (m, 1H), 8.4 (m, 1H).
  • 2
  • [ 131337-81-0 ]
  • [ 53174-98-4 ]
YieldReaction ConditionsOperation in experiment
85% With manganese(IV) oxide; In dichloromethane; at 20.0℃; To a solution of compound B-131 (4.0 g, 24 mmol) in dichloromethane (40 mL) was added manganese dioxide (21 g, 24 mmol) at room temperature. The mixture was stirred at room temperature overnight. On completion, the mixture was filtered, and the filtrate was concentrated in vacuo to give compound B-132 (3.4 g, 85% yield) as a yellow solid. LCMS: (ES+) m/z (M+H)+ = 164.1, tR=0.537.
 

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[ 131337-81-0 ]

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