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Chemical Structure| 1312772-66-9 Chemical Structure| 1312772-66-9

Structure of 1312772-66-9

Chemical Structure| 1312772-66-9

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Product Details of [ 1312772-66-9 ]

CAS No. :1312772-66-9
Formula : C7H5ClN2O3
M.W : 200.58
SMILES Code : O=C(O)C1=NC(Cl)=C(C(N)=O)C=C1
MDL No. :MFCD24499931

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Application In Synthesis of [ 1312772-66-9 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1312772-66-9 ]

[ 1312772-66-9 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 1312772-66-9 ]
  • [ 53234-56-3 ]
YieldReaction ConditionsOperation in experiment
EXAMPLE 216-(4-chlorobenzylthio)-5-cyanopicolinic acid (52) <n="101"/> Step 1Synthesis of 6-chloro-5-cyanopicolinic acid (51) To a solution of 6-chloro-5-cyano-2-picoline 50 (3.0 g, 20 mmol) in COnC-H2SO4 (20 ml) was added CrO3 (4.9 g, 49 mmol) portionwise over 2 hr period while the reaction mixture was kept below 2O 0 C. After stirring overnight at room temperature, the mixture was poured into ice-water and the resulting solid was collected by filtration to give the crude 6-chloro-5-(aminocarbonyl)-2-picolinic acid which was dissolved in POCl3 (15 ml). After heating at reflux for 30 min, the reaction mixture was concentrated in vacuo and the residue was treated with ice water. The precipitate was collected by filtration to afford 2.5 g (71% for 2 steps) of the desired product 51. 1H NMR (600MHz, DMSO-d6) delta 8.65 (delta, IH, theta= 7.8 Hzeta), 8.17 (delta, IH, theta= 7.8 Hzeta)
 

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