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Chemical Structure| 1282516-32-8 Chemical Structure| 1282516-32-8

Structure of 1282516-32-8

Chemical Structure| 1282516-32-8

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Product Details of [ 1282516-32-8 ]

CAS No. :1282516-32-8
Formula : C8H8ClNO3
M.W : 201.61
SMILES Code : O=CC1=C(C=NC(Cl)=C1)OCOC
MDL No. :MFCD27942957

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Application In Synthesis of [ 1282516-32-8 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1282516-32-8 ]

[ 1282516-32-8 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 1282516-32-8 ]
  • [ 1060804-53-6 ]
YieldReaction ConditionsOperation in experiment
6 g With hydrogenchloride; In tetrahydrofuran; water; at 60℃; for 1h; A solution of 2-chloro- 5-(methoxymethoxy)pyridine-4-carbaldehyde ( 12 g, 59.52 mmol, 1.00 equiv) in tetrahydrofuran (80 mL) and 3M HCl (130 mL) was stirred for 1 h at 60C. The reaction mixture was cooled to rt and the pH value of the solution was adjusted to 7 with 5% aqueous sodium carbonate solution. The organic layer was collected and the aqueous layer was extracted with 400 mL of ethyl acetate. The combined organic layers were dried over anhydrous sodium sulfate, filtered and concentrated under vacuum. The residue was purified on a silica gel column eluted with ethyl acetate/petroleum ether (1 :3) to give 6 g (64%) of 2-chloro-5-hydroxypyridine-4-carbaldehyde as a light yellow solid. TLC: petroleum ether: ethyl acetate=2:1 , Rf = 0.3.
 

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