127561-18-6|1-(6-(Trifluoromethyl)pyridin-2-yl)piperazine| Ambeed

Size	Price	VIP Price	US Stock	Global Stock	In Stock
{[ item.pr_size ]}		Inquiry {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate,item.pr_is_large_size_no_price, item.vip_usd) ]}

US Stock: ship in 0-1 business day
Global Stock: ship in 5-7 days

{[ item.pr_size ]}

In Stock

- +

Please Login or Create an Account to: See VIP prices and availability

US Stock: ship in 0-1 business day
Global Stock: ship in 2 weeks

Quality Control of [ 127561-18-6 ] Purity: 95% SDS Specification

COA

Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.

NMR

Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.

CNMR

Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.

HPLC

Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.

LC-MS

Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.

1-2 Day Shipping
High Quality
Technical Support

Product Details of [ 127561-18-6 ]

CAS No. :	127561-18-6
Formula :	C₁₀H₁₂F₃N₃
M.W :	231.22
SMILES Code :	FC(F)(F)C1=CC=CC(=N1)N1CCNCC1
MDL No. :	MFCD00114706

Safety of [ 127561-18-6 ]

GHS Pictogram:
Signal Word:	Warning
Hazard Statements:	H302-H315-H319-H335
Precautionary Statements:	P261-P280-P301+P312-P302+P352-P305+P351+P338

Application In Synthesis of [ 127561-18-6 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Downstream synthetic route of [ 127561-18-6 ]

[ 127561-18-6 ] Synthesis Path-Downstream 1~35

1
[ 79-04-9 ]
[ 127561-18-6 ]
2-chloro-1-[4-(6-trifluoromethyl-pyridin-2-yl)-piperazin-1-yl]-ethanone [ No CAS ]

References: [1]Bioorganic and Medicinal Chemistry Letters,2002,vol. 12,p. 3187 - 3190.

2
[ 110-85-0 ]
[ 39890-95-4 ]
[ 127561-18-6 ]

Yield	Reaction Conditions	Operation in experiment
81.4%	In acetonitrile;	a. 54.4 g of 2-chloro-6-trifluoromethyl pyridine are dissolved into a mixture of 350 ml of acetonitrile and 77.4 g of anhydrous piperazine. The mixture is filtered and washed with acetonitrile. The solvent is evaporated. The residue is taken up with dichloromethane and washed with water. The solution is dried over magnesium sulfate. The solvent is evaporated and the residue distilled, to obtain 56.4 g of 1-[6-(trifluoromethyl)-2-pyridinyl]piperazine (81.4% yield), having a boiling point of 103 C. at 0.05 mm Hg.
81.4%	In acetonitrile;	a. 54.4 g of 2-chloro-6-trifluoromethyl pyridine are dissolved into a mixture of 350 ml of acetonitrile and 77.4 g of anhydrous piperazine. The mixture is filtered and washed with acetonitrile. The solvent is evaporated. The residue is taken up with dichloromethane and washed with water. The solution is dried over magnesium sulfate. The solvent is evaporated and the residue distilled, to obtain 56.4 g of 1-[6-(trifluoromethyl)-2-pyridinyl]piperazine (81.4% yield), having a boiling point of 103 C at 0.05 mm Hg.
	With triethylamine; In DMF (N,N-dimethyl-formamide); at 100.0℃;	A solution of 2-chloro-6-(trifluoromethyl)pyridine (1.0 g, 5.5 mmol), piperazine (1.4 g, 16.0 mmol), and triethylamine (1.5 mL, 11.0 mmol) were mixed in DMF (10 mL) in a dealed tube. The mixture was heated at 100 C. overnight. The reaction mixture was concentrated and chromatographed on silica gel (ethyl acetate to EA/MeOH/Et3N=9:1:0.5) to give 1.05 g of the desired product. MS calculated for C10H12F3N3: (M+H) 232.1; found 232.1.

References: [1]Journal of Medicinal Chemistry,2006,vol. 49,p. 3719 - 3742.
[2]Journal of labelled compounds and radiopharmaceuticals,2004,vol. 47,p. 531 - 542.
[3]Patent: US5135931,1992,A .
[4]Patent: EP462638,1991,A1 .
[5]Patent: US2006/4018,2006,A1 .Location in patent: Page/Page column 39.

3
[ 574-98-1 ]
[ 127561-18-6 ]
[ 139722-72-8 ]

Yield	Reaction Conditions	Operation in experiment
33%	With sodium carbonate; In dichloromethane;	b. A mixture of 69.3 g of <strong>[127561-18-6]1-[6-(trifluoromethyl)-2-pyridinyl]piperazine</strong>, and 129.6 g of N-(2-bromoethyl)phthalimide and 57.2 g of sodium carbonate is heated at reflux for 23 hours. The resulting precipitate is filtered off and the ethanol evaporated. The concentrate is dissolved in dichloromethane, washed with water, dried over magnesium sulfate, and evaporated. The resulting precipitate is recrystallized from isopropanol to give 39.5 g of 2-[2-[4-[6-(trifluoromethyl)-2-pyridinyl]-1-piperazinyl]ethyl]-1H-isoindole-1,3-dione (yield 33%).

References: [1]Journal of labelled compounds and radiopharmaceuticals,2004,vol. 47,p. 531 - 542.
[2]Patent: EP462638,1991,A1 .

4
[ 86604-86-6 ]
[ 127561-18-6 ]
6-trifluoromethyl-2-[4-(6-trifluoromethyl-pyridin-2-yl)-piperazin-1-yl]-1H-benzoimidazole [ No CAS ]

References: [1]Journal of Medicinal Chemistry,2006,vol. 49,p. 3719 - 3742.

5
[ 127561-18-6 ]
[ 139722-73-9 ]

References: [1]Journal of labelled compounds and radiopharmaceuticals,2004,vol. 47,p. 531 - 542.

6
[ 127561-18-6 ]
[ 845271-52-5 ]

References: [1]Journal of labelled compounds and radiopharmaceuticals,2004,vol. 47,p. 531 - 542.

7
[ 127561-18-6 ]
2-amino-1-[4-(6-trifluoromethyl-pyridin-2-yl)-piperazin-1-yl]-ethanone [ No CAS ]

References: [1]Bioorganic and Medicinal Chemistry Letters,2002,vol. 12,p. 3187 - 3190.

8
[ 127561-18-6 ]
3-(2,4-dioxo-3,4,7,8-tetrahydro-2H,5H-thiopyrano[4,3-d]pyrimidin-1-yl)-N-{2-oxo-2-[4-(6-trifluoromethyl-pyridin-2-yl)-piperazin-1-yl]-ethyl}-propionamide [ No CAS ]

References: [1]Bioorganic and Medicinal Chemistry Letters,2002,vol. 12,p. 3187 - 3190.

9
[ 127561-18-6 ]
1-{2-oxo-2-[4-(6-trifluoromethyl-pyridin-2-yl)-piperazin-1-yl]-ethyl}-3,5,7-triaza-1-azonia-tricyclo[3.3.1.1^3,7]decane; chloride [ No CAS ]

References: [1]Bioorganic and Medicinal Chemistry Letters,2002,vol. 12,p. 3187 - 3190.

10
[ 109-70-6 ]
[ 127561-18-6 ]
C₁₃H₁₇ClF₃N₃ [ No CAS ]