Structure of 1256944-96-3
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The BI-3802 was designed by Boehringer Ingelheim and could be obtained free of charge through the Boehringer Ingelheim open innovation portal opnMe.com, associated with its negative control.
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CAS No. : | 1256944-96-3 |
Formula : | C9H13ClFNO |
M.W : | 205.66 |
SMILES Code : | C[C@@H](N)C1=CC=C(F)C(OC)=C1.[H]Cl |
MDL No. : | MFCD16294081 |
InChI Key : | HBJULLIYARHDSU-FYZOBXCZSA-N |
Pubchem ID : | 53484667 |
GHS Pictogram: |
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Signal Word: | Warning |
Hazard Statements: | H302-H315-H319-H335 |
Precautionary Statements: | P261-P305+P351+P338 |
Num. heavy atoms | 13 |
Num. arom. heavy atoms | 6 |
Fraction Csp3 | 0.33 |
Num. rotatable bonds | 2 |
Num. H-bond acceptors | 3.0 |
Num. H-bond donors | 1.0 |
Molar Refractivity | 52.34 |
TPSA ? Topological Polar Surface Area: Calculated from |
35.25 Ų |
Log Po/w (iLOGP)? iLOGP: in-house physics-based method implemented from |
0.0 |
Log Po/w (XLOGP3)? XLOGP3: Atomistic and knowledge-based method calculated by |
2.05 |
Log Po/w (WLOGP)? WLOGP: Atomistic method implemented from |
2.75 |
Log Po/w (MLOGP)? MLOGP: Topological method implemented from |
2.25 |
Log Po/w (SILICOS-IT)? SILICOS-IT: Hybrid fragmental/topological method calculated by |
2.02 |
Consensus Log Po/w? Consensus Log Po/w: Average of all five predictions |
1.81 |
Log S (ESOL):? ESOL: Topological method implemented from |
-2.62 |
Solubility | 0.498 mg/ml ; 0.00242 mol/l |
Class? Solubility class: Log S scale |
Soluble |
Log S (Ali)? Ali: Topological method implemented from |
-2.42 |
Solubility | 0.784 mg/ml ; 0.00381 mol/l |
Class? Solubility class: Log S scale |
Soluble |
Log S (SILICOS-IT)? SILICOS-IT: Fragmental method calculated by |
-2.88 |
Solubility | 0.274 mg/ml ; 0.00133 mol/l |
Class? Solubility class: Log S scale |
Soluble |
GI absorption? Gatrointestinal absorption: according to the white of the BOILED-Egg |
High |
BBB permeant? BBB permeation: according to the yolk of the BOILED-Egg |
Yes |
P-gp substrate? P-glycoprotein substrate: SVM model built on 1033 molecules (training set) |
No |
CYP1A2 inhibitor? Cytochrome P450 1A2 inhibitor: SVM model built on 9145 molecules (training set) |
No |
CYP2C19 inhibitor? Cytochrome P450 2C19 inhibitor: SVM model built on 9272 molecules (training set) |
No |
CYP2C9 inhibitor? Cytochrome P450 2C9 inhibitor: SVM model built on 5940 molecules (training set) |
No |
CYP2D6 inhibitor? Cytochrome P450 2D6 inhibitor: SVM model built on 3664 molecules (training set) |
No |
CYP3A4 inhibitor? Cytochrome P450 3A4 inhibitor: SVM model built on 7518 molecules (training set) |
No |
Log Kp (skin permeation)? Skin permeation: QSPR model implemented from |
-6.1 cm/s |
Lipinski? Lipinski (Pfizer) filter: implemented from |
0.0 |
Ghose? Ghose filter: implemented from |
None |
Veber? Veber (GSK) filter: implemented from |
0.0 |
Egan? Egan (Pharmacia) filter: implemented from |
0.0 |
Muegge? Muegge (Bayer) filter: implemented from |
0.0 |
Bioavailability Score? Abbott Bioavailability Score: Probability of F > 10% in rat |
0.55 |
PAINS? Pan Assay Interference Structures: implemented from |
0.0 alert |
Brenk? Structural Alert: implemented from |
0.0 alert: heavy_metal |
Leadlikeness? Leadlikeness: implemented from |
No; 1 violation:MW<1.0 |
Synthetic accessibility? Synthetic accessibility score: from 1 (very easy) to 10 (very difficult) |
1.92 |
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With sodium cyanoborohydride; acetic acid; In N,N-dimethyl-formamide; at 20℃; | General procedure BTo a solution of ketone (1 eq.) in DMF (0.38M) were added the amine (1.1 eq.), glacial AcOH (1.2 eq.) and NaBH(OAc)3 (1.4 eq.). The mixture was stirred at r.t. overnight and filtered. Purification was performed by preparative HPLC-MS.; Preparation 33: Methyl 4-[(lR,3S)-3-[[(lR)-l-(4-fluoro-3-methoxy-phenyl)ethyl]- amino]cyclopentyl]benzoateGeneral procedure B was followed using methyl 4-[(lR)-3-oxocyclopentyl]benzoate (preparation 32) as the ketone and (lR)-l-(4-fluoro-3-methoxyphenyl)ethylamine hydrochloride as the amine. The resulting isomers were separated by flash chromatography (gradient of 0-50% EtOAc in heptane containing 3% NEt3). The faster eluting peak was isolated to afford the title compound. IH NMR (300 MHz, DMSO) delta 7.86 (d, J = 8.3 Hz, 2H), 7.38 (d, J = 8.3 Hz, 2H), 7.15 (dd, J = 8.7, 1.8 Hz, IH), 7.09 (dd, J = 11.5, 8.3 Hz, IH), 6.91 - 6.85 (m, IH), 3.83 (2 s, 6H), 3.80 - 3.70 (m, IH), 3.05 - 2.86 (m, 2H), 2.22 - 1.52 (m, 5H), 1.41 - 1.27 (m, IH), 1.23 (d, J = 6.6 Hz, 3H). | |
With sodium tris(acetoxy)borohydride; acetic acid; In N,N-dimethyl-formamide; at 20℃; | Intermediate 2: Methyl 4-[( lR,3S)-3-[[(lR)-l-(4-Fluoro-3-methoxy-phenyl)- ethyl]-amino]cyclopentyl]benzoateTo a solution of Intermediate 1 in DMF (0.38M) were added (lR)-l-(4-fluoro-3- methoxyphenyl)ethylamine hydrochloride (1.1 eq.), glacial AcOH (1.2 eq.) and NaBH(OAc)3 (1.4 eq.). The mixture was stirred at r.t. overnight and filtered. The resulting isomers were separated by flash chromatography (gradient of 0-50% EtOAc in heptane containing 3% Et3N). The faster eluting peak was isolated to afford the title compound 1H NMR (300 MHz, DMSO) delta 7.86 (d, J = 8.3 Hz, 2H), 7.38 (d, J = 8.3 Hz, 2H), 7.15 (dd, J = 8.7, 1.8 Hz, 1H), 7.09 (dd, J = 11.5, 8.3 Hz, 1H), 6.92 - 6.84 (m, 1H), 3.82 (2 s, 6H), 3.80 - 3.70 (m, 1H), 2.96 (dd, J = 19.0, 8.6 Hz, 2H), 2.22 - 2.02 (m, 2H), 2.01 - 1.52 (m, 4H), 1.41 - 1.27 (m, 1H), 1.23 (d, J = 6.6 Hz, 3H). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
31% | Intermediate 2: Ethyl 2-[4-[( lR,3S)-3-[[( lR)-l-(4-fluoro-3-methoxy- phenyl)-ethyl]amino]cyclopentyl]phenoxy]acetateA solution of Intermediate 3 (2 g, 7.6 mmol) in acetonitrile (30 mL) was treated with (lR)-l-(4-fluoro-3-methoxyphenyl)ethylamine hydrochloride (1.56 g, 7.6 mmol), NaBH(OAc)3 (15.2 mmol) and AcOH (0.70 mL) and stirred overnight at rt. Sat.Na2C03 was added, and the mixture was extracted with EtOAc. The combined organic extracts were washed with brine, dried over MgS04, and concentrated in vacuo. The residual oil was purified by flash chromatography (gradient of 20 - 80% EtAOc/1%2- propanol/0.5% Et3N in heptane/2.5% Et3N). The faster eluting isomer was collected to afford the title compound in 31% yield as an oil.XH NMR (300 MHz, DMSO) delta 7.18 - 7.04 (m, 4H), 6.87 (ddd, J = 8.2, 4.5, 2.0 Hz, 1H), 6.84 - 6.77 (m, 2H), 4.70 (s, 2H), 4.16 (q, J = 7.1 Hz, 2H), 3.82 (s, 3H), 3.75 (q, J = 6.5 Hz, 1H), 2.94 - 2.74 (m, 2H), 2.19 - 1.96 (m, 2H), 1.93 - 1.49 (m, 4H), 1.35 - 1.16 (m, 7H). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
31% | With NaBH(OAc)3; In acetonitrile; at 20℃; for 2h; | A solution of Intermediate 1 (3.25 mmol) in acetonitrile (4 mL) was treated with (lR)-l-(4-fluoro-3-methoxyphenyl)ethylamine hydrochloride (3.57 mmol) and NaBH(OAc)3 (4.87 mmol) for 2 h at rt. The reaction mixture was diluted with additional acetonitrile (10 mL) and loaded on silica gel. The two diastereomers were separated by flash chromatography (gradient of 0-50% of EtOAc in n-heptane). The title compound was obtained in 31% yield as the faster eluting isomer.*H NMR (300 MHz, CDCI3) delta 7.23 - 7.10 (m, 4H), 7.01 (dd, J = 11.1, 8.2 Hz, 2H), 6.82 (ddd, J = 8.1, 4.3, 1.9 Hz, 1H), 4.14 (q, J = 7.2 Hz, 2H), 3.91 (s, 3H), 3.85 (q, J = 6.1 Hz, 1H), 3.56 (s, 2H), 3.13 - 3.00 (m, 1H), 2.99 - 2.84 (m, 1H), 2.26 - 2.13 (m, 1H), 2.08 - 1.89 (m, 2H), 1.85 - 1.30 (m, 7H), 1.24 (d, J = 7.1 Hz, 3H). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
22% | In a round-bottom flask Intermediate 1 (179 mg, 1.0 mmol) and (lR)-l-(4-fluoro- 3-methoxyphenyl)ethylamine hydrochloride (206 mg, 1.0 mmol) was suspended in CH3CN (4 mL), sodium triacetoxyborohydride (279 mg, 1.4 mmol) followed by acetic acid (60 mu) was added and the reaction mixture stirred at roomtemperature for 16h. Saturated NaHC03, aq (3 mL) was added and the product was extracted with CH2CI2. The combined organic phases were concentrated and purified by flash chromatography (eluent: 50-100% EtOAc in heptane) to yield the title compound : 72 mg (22%). 1H NMR (300 MHz, CDCI3) delta 8.03 (d, J = 2.4 Hz, 1H), 7.62 (td, J = 8.1, 2.6 Hz, 1H), 7.06 - 6.94 (m, 2H), 6.86 - 6.78 (m, 2H), 3.90 (s, 3H), 3.83 (q, J = 6.6 Hz, 1H), 3.16 - 3.02 (m, 1H), 3.02 - 2.87 (m, 1H), 2.27 - 2.14 (m, 1H), 2.11 - 1.92 (m, 2H), 1.81 - 1.56 (m, 2H), 1.42 - 1.31 (m, 4H). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
78% | Intermediate-37 (0.103 g, 0.333 mmol) was added to a solution of (R)-1-(naphthalen-1- yl)ethanamine (0.057 g, 0.333 mmol) in dichloroethane (3 ml) and resulting mixture was stined at 25 C for 5 hrs. The reaction mixture was allowed to 0 C and added sodium triacetoxyborohydride (0.106 g, 0.499 mmol) then allowed to 25 C and further maintained for 16 hours. TLC showed the reaction completion. The reaction mixture was diluted withwater (25 ml) and dichloromethane (25 ml). The phases were separated and the aqueous phase was extracted with dichloromethane (2 x 5 ml). The combined organic extract was washed with water (2 x 25 ml), brine (50 ml) and dried over anhydrous sodium sulphate, filtered and concentrated in vacuo to get 1 .5g of the crude residue. This residue was purified by column chromatography over silica gel (100-200 mesh) with an isocratic elution of 35%ethyl acetate in petroleum ether to afford title compound (0. 12g, 78%) as off white solid. |
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