Home Cart Sign in  
Chemical Structure| 1215071-17-2 Chemical Structure| 1215071-17-2

Structure of 1215071-17-2

Chemical Structure| 1215071-17-2

*Storage: {[sel_prStorage]}

*Shipping: {[sel_prShipping]}

,{[proInfo.pro_purity]}

4.5 *For Research Use Only !

{[proInfo.pro_purity]}
Cat. No.: {[proInfo.prAm]} Purity: {[proInfo.pro_purity]}

Change View

Size Price VIP Price

US Stock

Global Stock

In Stock
{[ item.pr_size ]} Inquiry {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate,item.pr_is_large_size_no_price, item.vip_usd) ]}

US Stock: ship in 0-1 business day
Global Stock: ship in 5-7 days

  • {[ item.pr_size ]}

In Stock

- +

Please Login or Create an Account to: See VIP prices and availability

US Stock: ship in 0-1 business day
Global Stock: ship in 2 weeks

  • 1-2 Day Shipping
  • High Quality
  • Technical Support
Product Citations

Alternative Products

Product Details of [ 1215071-17-2 ]

CAS No. :1215071-17-2
Formula : C10H15F2NO3
M.W : 235.23
SMILES Code : CC(C)(C)OC(=O)N1CCC(=O)C(F)(F)C1
MDL No. :MFCD16140378

Safety of [ 1215071-17-2 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Application In Synthesis of [ 1215071-17-2 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1215071-17-2 ]

[ 1215071-17-2 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 1209780-71-1 ]
  • [ 1215071-17-2 ]
YieldReaction ConditionsOperation in experiment
With Dess-Martin periodane; In dichloromethane; at 20℃;Inert atmosphere; cooling with ice; ferf-Butyl 4-(2-ethoxy-2-oxoethylidene)-3,3-difluoropiperidine-1 -carboxylate: In a flame dried round-bottomed flask equipped with a magnetic stir bar and under inert atmosphere (N2), to an ice-cold solution of ferf-butyl 3,3-difluoro-4-hydroxypiperidine-1- carboxylate (2.40 g, 10.00 mmol) in dry CH2CI2 (50 ml.) was added a solution of Dess- Martin periodinane (50 ml. of a 15% solution in CH2CI2, 24.00 mmol). The reaction mixture was stirred at rt until completion of the reaction. Sat. aq. NaHC03 (50 ml.) was then added followed by 10% aq. Na2S03 (50 ml_). The mixture was stirred at rt for 1 h, the layers separated and the aq. layer extracted with CH2CI2 (3x). The combined org. extracts were dried over MgS04, filtered, and concentrated under reduced pressure. The crude residue was redissolved in CH2CI2 (30 ml.) and stirred in the presence of molecular sieves for 24 h, filtered and concentrated under reduced pressure to give ferf-butyl 3,3-difluoro-4- oxopiperidine-1 -carboxylate as a yellow solid. In a flame dried round-bottomed flask equipped with a magnetic stir bar and under inert atmosphere (N2), to NaH (45 mg, 1 .12 mmol, 60% dispersion in oil washed with heptane) was added a solution of triethyl phosphonoacetate (262 mg, 1.17 mmol) in dry THF (10 ml.) at 0 C. The reaction mixture was stirred at 0 C for 30 min. Molecular sieves were then added followed by a solution of ferf-butyl 3,3-difluoro-4-oxopiperidine-1-carboxylate (220 mg, 0.93 mmol) in THF (5 ml_). The reaction mixture was stirred at 0 C for 30 min and at rt for 1 h. Water was then added and the mixture extracted with EA (3x). The combined org. extracts were dried over MgS04, filtered, and concentrated under reduced pressure to give the title compound as a yellow oil (mixture of E and Z isomers). LC-MS- conditions 08: tR = 0.88 and 0.93 min; [M-CH3+H]+ = 291.27.
With Dess-Martin periodane; In dichloromethane; at 20℃;Inert atmosphere; tert-Butyl 4-(2-ethoxy-2-oxoethylidene)-3,3-difluoropiperidine-1-carboxylate In a flame dried round-bottomed flask equipped with a magnetic stir bar and under inert atmosphere (N2), to an ice-cold solution of <strong>[1209780-71-1]tert-butyl <strong>[1209780-71-1]3,3-difluoro-4-hydroxypiperidine-1-carboxylate</strong></strong> (2.40 g, 10.00 mmol) in dry CH2Cl2 (50 mL) was added a solution of Dess-Martin periodinane (50 mL of a 15% solution in CH2Cl2, 24.00 mmol). The reaction mixture was stirred at rt until completion of the reaction. Sat. aq. NaHCO3 (50 mL) was then added followed by 10% aq. Na2SO3 (50 mL). The mixture was stirred at rt for 1 h, the layers separated and the aq. layer extracted with CH2Cl2 (3*). The combined org. extracts were dried over MgSO4, filtered, and concentrated under reduced pressure. The crude residue was redissolved in CH2Cl2 (30 mL) and stirred in the presence of molecular sieves for 24 h, filtered and concentrated under reduced pressure to give tert-butyl 3,3-difluoro-4-oxopiperidine-1-carboxylate as a yellow solid.
With Dess-Martin periodane; In dichloromethane; at 20℃;Inert atmosphere; In a flame dried round-bottomed flask equipped with a magnetic stir bar and under inert atmosphere (N2), to an ice-cold solution of terf-butyl 3,3-difluoro-4-hydroxypiperidine-1 - carboxylate (2.40 g, 10.00 mmol) in dry CH2CI2 (50 mL) was added a solution of Dess- Martin periodinane (50 mL of a 15% solution in CH2CI2, 24.00 mmol). The reaction mixture was stirred at rt until completion of the reaction. Sat. aq. NaHC03 (50 mL) was then added followed by 10% aq. Na2S03 (50 mL). The mixture was stirred at rt for 1 h, the layers separated and the aq. layer extracted with CH2CI2 (3x). The combined org. extracts were dried over MgS04, filtered, and concentrated under reduced pressure. The crude residue was redissolved in CH2CI2 (30 mL) and stirred in the presence of molecular sieves for 24 h, filtered, and concentrated under reduced pressure to give feri-butyl 3,3-difluoro-4- oxopiperidine-1 -carboxylate as a yellow solid.
  • 2
  • [ 1215071-17-2 ]
  • [ 53848-17-2 ]
  • [ 1429256-80-3 ]
YieldReaction ConditionsOperation in experiment
With toluene-4-sulfonic acid; In toluene; for 3h;Reflux; Dean-Stark; General procedure: Mixture of tert-butyl 3,3-difluoro-4-oxopiperidine-1-carboxylate (200 mg, 0.85 mmol), 2-bromo anilines (2.33 mmol) and catalytic amount of para toluenesulfonic acid in toluene (20 mL) were reflux and the water was removed azeotropically using a Dean-Stark apparatus for 3 h. After completion of the reaction (TLC), the reaction mixture was concentrated in vacuo at nitrogen to give the product as a yellow liquid of (E)-tert-butyl 3,3-difluoro-4-(phenylimino)piperidine-1-carboxylate derivatives (8a-h). Each derivative (8a-h) was taken in seal tube with pyridine (10 mL) as solvent under nitrogen atmosphere, to this diisopropylethylamine (439.5 mg, 3.4 mmol) and bis(triphenylphosphine) palladium(II) dichloride (59.67 mg, 0.085 mmol) were added, and then the mixture was degassed with nitrogen and heated to 120 C for 16 h. The completion of the reaction was monitored by TLC and after being cooled to room temperature, the reaction mixture was concentrated in vacuo to give the crude product which was purified by column chromatography over silica gel (60-120 mesh) using 10-20% ethyl acetate and hexane as eluent to get pure product (9a-h).
 

Historical Records

Technical Information

Categories

Related Functional Groups of
[ 1215071-17-2 ]

Fluorinated Building Blocks

Chemical Structure| 211108-50-8

A304821 [211108-50-8]

tert-Butyl 3-fluoro-4-oxopiperidine-1-carboxylate

Similarity: 0.92

Chemical Structure| 1093759-80-8

A362570 [1093759-80-8]

tert-Butyl 4-(2,2,2-trifluoroacetyl)piperidine-1-carboxylate

Similarity: 0.84

Chemical Structure| 1255666-48-8

A164117 [1255666-48-8]

tert-Butyl 4-amino-3,3-difluoropiperidine-1-carboxylate

Similarity: 0.82

Chemical Structure| 1245648-32-1

A210794 [1245648-32-1]

tert-Butyl 4-oxo-2-(trifluoromethyl)piperidine-1-carboxylate

Similarity: 0.82

Chemical Structure| 1303973-22-9

A117863 [1303973-22-9]

tert-Butyl 4-(aminomethyl)-3,3-difluoropiperidine-1-carboxylate

Similarity: 0.81

Amides

Chemical Structure| 211108-50-8

A304821 [211108-50-8]

tert-Butyl 3-fluoro-4-oxopiperidine-1-carboxylate

Similarity: 0.92

Chemical Structure| 1093759-80-8

A362570 [1093759-80-8]

tert-Butyl 4-(2,2,2-trifluoroacetyl)piperidine-1-carboxylate

Similarity: 0.84

Chemical Structure| 1255666-48-8

A164117 [1255666-48-8]

tert-Butyl 4-amino-3,3-difluoropiperidine-1-carboxylate

Similarity: 0.82

Chemical Structure| 1245648-32-1

A210794 [1245648-32-1]

tert-Butyl 4-oxo-2-(trifluoromethyl)piperidine-1-carboxylate

Similarity: 0.82

Chemical Structure| 1303973-22-9

A117863 [1303973-22-9]

tert-Butyl 4-(aminomethyl)-3,3-difluoropiperidine-1-carboxylate

Similarity: 0.81

Ketones

Chemical Structure| 211108-50-8

A304821 [211108-50-8]

tert-Butyl 3-fluoro-4-oxopiperidine-1-carboxylate

Similarity: 0.92

Chemical Structure| 1093759-80-8

A362570 [1093759-80-8]

tert-Butyl 4-(2,2,2-trifluoroacetyl)piperidine-1-carboxylate

Similarity: 0.84

Chemical Structure| 1245648-32-1

A210794 [1245648-32-1]

tert-Butyl 4-oxo-2-(trifluoromethyl)piperidine-1-carboxylate

Similarity: 0.82

Chemical Structure| 1283720-88-6

A161260 [1283720-88-6]

Benzyl 3,3-difluoro-4-oxopiperidine-1-carboxylate

Similarity: 0.79

Chemical Structure| 79099-07-3

A135252 [79099-07-3]

1-Boc-4-Piperidone

Similarity: 0.75

Related Parent Nucleus of
[ 1215071-17-2 ]

Piperidines

Chemical Structure| 211108-50-8

A304821 [211108-50-8]

tert-Butyl 3-fluoro-4-oxopiperidine-1-carboxylate

Similarity: 0.92

Chemical Structure| 1093759-80-8

A362570 [1093759-80-8]

tert-Butyl 4-(2,2,2-trifluoroacetyl)piperidine-1-carboxylate

Similarity: 0.84

Chemical Structure| 1255666-48-8

A164117 [1255666-48-8]

tert-Butyl 4-amino-3,3-difluoropiperidine-1-carboxylate

Similarity: 0.82

Chemical Structure| 1245648-32-1

A210794 [1245648-32-1]

tert-Butyl 4-oxo-2-(trifluoromethyl)piperidine-1-carboxylate

Similarity: 0.82

Chemical Structure| 1303973-22-9

A117863 [1303973-22-9]

tert-Butyl 4-(aminomethyl)-3,3-difluoropiperidine-1-carboxylate

Similarity: 0.81