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Type HazMat fee for 500 gram (Estimated)
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Chemical Structure| 12135-22-7 Chemical Structure| 12135-22-7

Structure of 12135-22-7

Chemical Structure| 12135-22-7

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Product Citations

Product Citations

Calabretta, Lindsey O. ; Yang, Jinyi ; Raines, Ronald T. ;

Abstract: The field of cell-penetrating peptides is dominated by the use of oligomers of arginine residues. Octanol-water partitioning in the presence of an anionic lipid is a validated proxy for cell-penetrative efficacy. Here, we add one, two, or three N-Me groups to Ac-Arg-NH2 and examine the effects on octanol-water partitioning. In the absence of an anionic lipid, none of these arginine derivatives can be detected in the octanol layer. In the presence of sodium dodecanoate, however, increasing N-methylation correlates with increasing partitioning into octanol, which is predictive of higher cell-penetrative ability. We then evaluated fully Nα-methylated oligoarginine peptides and observed an increase in their cellular penetration compared with canonical oligoarginine peptides in some contexts. These findings indicate that a simple modification, Nα-methylation, can enhance the performance of cell-penetrating peptides.

Keywords: guanidino group ; octanol-water partitioning ; peptoid ; topological polar surface area

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Product Details of [ 12135-22-7 ]

CAS No. :12135-22-7
Formula : H2O2Pd
M.W : 140.43
SMILES Code : [Pd+2].[OH-].[OH-]
MDL No. :MFCD00064599

Safety of [ 12135-22-7 ]

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H315-H319-H228
Precautionary Statements:P240-P210-P241-P264-P280-P302+P352-P370+P378-P337+P313-P305+P351+P338-P362+P364-P332+P313
Class:4.1
UN#:3178
Packing Group:
 

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