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Chemical Structure| 1196396-14-1 Chemical Structure| 1196396-14-1

Structure of 1196396-14-1

Chemical Structure| 1196396-14-1

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2-(4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenoxy)pyridine

CAS No.: 1196396-14-1

,98%

4.5 *For Research Use Only !

Cat. No.: A1808113 Purity: 98%

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    Product Details of [ 1196396-14-1 ]

    CAS No. :1196396-14-1
    Formula : C17H20BNO3
    M.W : 297.16
    SMILES Code : CC1(C)C(C)(C)OB(C2=CC=C(OC3=NC=CC=C3)C=C2)O1
    MDL No. :MFCD18384047

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    Application In Synthesis of [ 1196396-14-1 ]

    * All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

    • Downstream synthetic route of [ 1196396-14-1 ]

    [ 1196396-14-1 ] Synthesis Path-Downstream   1~1

    • 1
    • [ 1196396-14-1 ]
    • [ 185099-68-7 ]
    • [ 1222495-67-1 ]
    YieldReaction ConditionsOperation in experiment
    With potassium carbonate; lithium chloride;tetrakis(triphenylphosphine) palladium(0); In 1,2-dimethoxyethane; water; for 16h;Reflux; 2.3/ 3-[4-(Pyridin-2-yloxy)phenyl]-8-azabicyclo[3.2.1]oct-2-ene-8-carboxylic acid tert-butyl ester 2-[4-(4,4,5,5-Tetramethyl[1,3,2]dioxaborolan-2-yl)phenoxy]pyridine (0.62 g, 2.1 mmol), <strong>[185099-68-7]3-trifluoromethanesulfonyloxy-8-azabicyclo[3.2.1]oct-2-ene-8-carboxylic acid tert-butyl ester</strong> (0.75 g, 2.1 mmol) (intermediate 1), tetrakis(triphenylphosphine)-palladium (0.24 g, 0.21 mmol) and lithium chloride (0.107 g, 2.52 mmol) are placed in 10 ml of DME and 2.6 ml of a 2N aqueous solution of K2CO3. The reaction medium is refluxed for 16 h. After hydrolysis and extraction with ethyl acetate, the organic phase is dried over MgSO4 and concentrated to dryness. The crude product obtained is chromatographed on silica gel, elution being carried out with a gradient of ethyl acetate in heptane ranging from 0% to 30%. 0.45 g of expected 3-[4-(pyridin-2-yl-oxy)phenyl]-8-azabicyclo[3.2.1]oct-2-ene-8-carboxylic acid tert-butyl ester is obtained. [M+H+]=379
     

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