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Chemical Structure| 1113-59-3 Chemical Structure| 1113-59-3
Chemical Structure| 1113-59-3

3-Bromopyruvic acid

CAS No.: 1113-59-3

3-Bromopyruvic acid is an inhibitor of hexokinase II with effective antitumor acitvity.

Synonyms: Bromopyruvic acid; Hexokinase II Inhibitor II, 3-BP; NSC 62343

4.5 *For Research Use Only !

Cat. No.: A376712 Purity: 96%

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Product Citations

Product Citations

Agarwal, Devesh S. ; Beteck, Richard M. ; Ilbeigi, Kayhan ; Caljon, Guy ; Legoabe, Lesetja J. ;

Abstract: A library of imidazo[1,2-a]pyridine-appended chalcones were synthesized and characterized using 1H NMR,13C NMR and HRMS. The synthesized analogs were screened for their antikinetoplastid activity against Trypanosoma cruzi, Trypanosoma brucei brucei, Trypanosoma brucei rhodesiense and Leishmania infantum. The analogs were also tested for their cytotoxicity activity against human lung fibroblasts and primary mouse macrophages. Among all screened derivatives, (E)-N-(4-(3-(2-chlorophenyl)acryloyl)phenyl)imidazo[1,2-a]pyridine-2-carboxamide was found to be the most active against T. cruzi and T. b. brucei exhibiting IC50 values of 8.5 and 1.35 μM, resp. Against T. b. rhodesiense, (E)-N-(4-(3-(4-bromophenyl)acryloyl)phenyl)imidazo[1,2-a]pyridine-2-carboxamide was found to be the most active with an IC50 value of 1.13 μM. All synthesized active analogs were found to be non-cytotoxic against MRC-5 and PMM with selectivity indexes of up to more than 50.

Keywords: antikinetoplastid ; ; drug likeliness properties ; ; neglected tropical diseases (NTDs) ; Trypanosoma brucei brucei ; Trypanosoma brucei rhodesiense

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Product Details of 3-Bromopyruvic acid

CAS No. :1113-59-3
Formula : C3H3BrO3
M.W : 166.96
SMILES Code : O=C(O)C(CBr)=O
Synonyms :
Bromopyruvic acid; Hexokinase II Inhibitor II, 3-BP; NSC 62343
MDL No. :MFCD00002587
InChI Key :PRRZDZJYSJLDBS-UHFFFAOYSA-N
Pubchem ID :70684

Safety of 3-Bromopyruvic acid

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H314
Precautionary Statements:P280-P305+P351+P338-P310
Class:8
UN#:3261
Packing Group:
 

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