Structure of 4-Methoxybenzyl alcohol
CAS No.: 105-13-5
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CAS No. : | 105-13-5 |
Formula : | C8H10O2 |
M.W : | 138.16 |
SMILES Code : | COC1=CC=C(CO)C=C1 |
MDL No. : | MFCD00004653 |
GHS Pictogram: |
![]() |
Signal Word: | Warning |
Hazard Statements: | H302-H315-H319 |
Precautionary Statements: | P501-P270-P264-P280-P337+P313-P305+P351+P338-P302+P352-P332+P313-P362-P301+P312+P330 |
Num. heavy atoms | 10 |
Num. arom. heavy atoms | 6 |
Fraction Csp3 | 0.25 |
Num. rotatable bonds | 2 |
Num. H-bond acceptors | 2.0 |
Num. H-bond donors | 1.0 |
Molar Refractivity | 39.06 |
TPSA ? Topological Polar Surface Area: Calculated from |
29.46 Ų |
Log Po/w (iLOGP)? iLOGP: in-house physics-based method implemented from |
1.97 |
Log Po/w (XLOGP3)? XLOGP3: Atomistic and knowledge-based method calculated by |
1.1 |
Log Po/w (WLOGP)? WLOGP: Atomistic method implemented from |
1.04 |
Log Po/w (MLOGP)? MLOGP: Topological method implemented from |
1.21 |
Log Po/w (SILICOS-IT)? SILICOS-IT: Hybrid fragmental/topological method calculated by |
1.67 |
Consensus Log Po/w? Consensus Log Po/w: Average of all five predictions |
1.4 |
Log S (ESOL):? ESOL: Topological method implemented from |
-1.7 |
Solubility | 2.75 mg/ml ; 0.0199 mol/l |
Class? Solubility class: Log S scale |
Very soluble |
Log S (Ali)? Ali: Topological method implemented from |
-1.31 |
Solubility | 6.75 mg/ml ; 0.0488 mol/l |
Class? Solubility class: Log S scale |
Very soluble |
Log S (SILICOS-IT)? SILICOS-IT: Fragmental method calculated by |
-2.33 |
Solubility | 0.654 mg/ml ; 0.00473 mol/l |
Class? Solubility class: Log S scale |
Soluble |
GI absorption? Gatrointestinal absorption: according to the white of the BOILED-Egg |
High |
BBB permeant? BBB permeation: according to the yolk of the BOILED-Egg |
Yes |
P-gp substrate? P-glycoprotein substrate: SVM model built on 1033 molecules (training set) |
No |
CYP1A2 inhibitor? Cytochrome P450 1A2 inhibitor: SVM model built on 9145 molecules (training set) |
Yes |
CYP2C19 inhibitor? Cytochrome P450 2C19 inhibitor: SVM model built on 9272 molecules (training set) |
No |
CYP2C9 inhibitor? Cytochrome P450 2C9 inhibitor: SVM model built on 5940 molecules (training set) |
No |
CYP2D6 inhibitor? Cytochrome P450 2D6 inhibitor: SVM model built on 3664 molecules (training set) |
No |
CYP3A4 inhibitor? Cytochrome P450 3A4 inhibitor: SVM model built on 7518 molecules (training set) |
No |
Log Kp (skin permeation)? Skin permeation: QSPR model implemented from |
-6.36 cm/s |
Lipinski? Lipinski (Pfizer) filter: implemented from |
0.0 |
Ghose? Ghose filter: implemented from |
None |
Veber? Veber (GSK) filter: implemented from |
0.0 |
Egan? Egan (Pharmacia) filter: implemented from |
0.0 |
Muegge? Muegge (Bayer) filter: implemented from |
1.0 |
Bioavailability Score? Abbott Bioavailability Score: Probability of F > 10% in rat |
0.55 |
PAINS? Pan Assay Interference Structures: implemented from |
0.0 alert |
Brenk? Structural Alert: implemented from |
0.0 alert: heavy_metal |
Leadlikeness? Leadlikeness: implemented from |
No; 1 violation:MW<1.0 |
Synthetic accessibility? Synthetic accessibility score: from 1 (very easy) to 10 (very difficult) |
1.0 |
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
95% | With poly(4-vinylpyridine) perchlorate; In neat (no solvent); at 20℃; for 0.416667h; | The substrate (alcohol, phenol or amine; 1.0 mmol) was treated with Ac2O (2.0 mmol) in the presence of P(4-VPH)ClO4 (50 mg) at room temperature under solvent-free conditions and magnetic stirring. After completion of the reaction as indicated by TLC, the mixture was diluted with Et2O (25 ml) and the catalyst allowed to settle down. The supernatant ethereal solution was decanted off, the catalyst washed with Et2O (2 ml) and the combined ethereal solution concentrated under vacuum to afford the product, identical(mp, IR, 1H and 13C NMR, and GC-MS) to an authentic sample of acetylated product. The recovered catalyst was dried at 50 C under vacuum for 2 h. The recovered catalyst, after drying, was reused for four more consecutive acetylation reactions of benzyl alcohol (1.0 mmol) affording 96, 96, 94, and 94% yields, respectively, in 22, 23, 23, and 25 min (Scheme 2). |
93% | With zinc(II) oxide; for 3h;Reflux; | General procedure: To a mixture of acetic acid (5 mL) and alcohol (1 mmol), ZnO nanopowder (0.05 mmol) was added. The mixture was stirred vigorously under reflux conditions for 3 hr. The reaction was monitored by TLC (CCl4: EtOAc, 4:1). Then, the reaction mixture was washed with an aqueous solution of sodium bicarbonate (20%) and filtered. The filtrate was extracted with ether (3 × 50 mL), washed with H2O (3× 10 mL) and dried over anhydrous magnesium sulfate. Evaporation of solvent under reduced pressure gave the desired acetate in specified yield (Table I). All the acetates were known and characterized according to their IR, 13C and 1H NMR spectra. |
93% | With yttrium iron garnet; In neat (no solvent); at 80℃; for 0.333333h;Green chemistry; | General procedure: Mixture of 0.005 g and glacial acetic acid was placed in a 50-mL round bottom flask, and was stirred for 5 min. Then, alcohol(1 mmol) was added to the solution, and reaction solution was stirred under reflux condition for specified time. The progress of reaction was monitored by TLC (acetone-n-hexane, 1 : 2). After completion of the reaction, catalyst was easily removed by shutting down the stirrer without using any external magnet. The product was purified by recrystallizationin hot ethanol. For the reaction times andthe structures and yields of the products, see Table 2. |
83.2% | With [PrSO3HN][SO3CF3] functionalized hierarchically porous nitrogen doped carbon; In toluene; at 50℃; for 1h;Catalytic behavior; | General procedure: Typically, 24 mg of catalyst was added to a mixture of benzyl alcohol/4-methoxybenzyl alcohol (3.33 mmol), acetic acid (10 mmol)and toluene (10 mL), and the reaction was carried out at 100 or 50 C.The concentrations of the produced benzyl acetate/4-methoxybenzylacetate and residual benzyl alcohol/4-methoxybenzyl alcohol wereanalyzed periodically by a Shimadzu 2014C GC-FID fitted with a HPINNOWAXcapillary column, and ethyl laurate was used as an internalstandard. The catalytic performance of the tested catalysts was evaluatedquantitatively by the conversion of benzyl alcohol/4-methoxybenzylalcohol, the yield of benzyl acetate/4-methoxybenzyl acetateand the selectivity to benzyl acetate/4-methoxybenzyl acetate, respectively.Additionally, the esterification processes were also monitored bya HP6890GC-5973MSD GC-MS. |
With N,N?,N??,N???-hexadecyltrimethylammonium bis(trifluoromethylsulfonyl)imide; Novozym 435 (immobilized Candida antarctica lipase B); at 50℃; for 4h;Green chemistry; Enzymatic reaction; | Three mmol of citronellol, geraniol, nerol or anisyl alcohol, and 1, 2 or 3mmol of acetic acid were added to 3mL screw-capped vials with teflon-lined septa. Then, the corresponding amount of [C16tma][NTf2] was added to reach a final IL concentration of 60 or 70% (w/w) with respect to the mass substrates. Reaction mixtures were pre-incubated at 50C for 10min, resulting in fully clear monophasic systems. Then, 80mg of MS13× per mmol of carboxylic acid were also added. The reaction was started by adding Novozym 435 (40mg/mmol of carboxylic acid) and the reaction was incubated for 4h at 50C while shaking (300rpm), or under 4W microwave irradiation (which provided a 50C constant temperature). For products analysis, aliquots (20muL) were taken at selected times and suspended in 500muL octane, and the resulting biphasic mixture was shaken to extract the products. The resulting mixture was centrifuged at 14,000rpm for 10min. Finally, 300muL of the octane extract were added to 100muL of a 100mM ethyl propionate (internal standard) solution in octane, and the final solution was analyzed by CG. For full recovery of the flavour ester products at 4h, the reaction mixtures were consecutively centrifuged four times at 14,000rpm (15min) and at room temperature, 21, 10 and 4C, which resulted in a top liquid phase of flavour ester and a bottom solid phase containing the SLIL. For the case of anisyl acetate, the reaction mixture was cooled in an ice bath for 3h, and the resulting solid mixture was placed in a centrifugal filter, then centrifuged at 16,000rpm (10min) and at 0C. This resulted in a top SLIL solid phase, which was retained inside the filter, and a bottom liquid phase of anisyl acetate. For all cases, a sample (10muL) of the resulting flavour ester phase was dissolved in 1mL acetone-delta6, then analyzed by 300MHz 1H NMR and 282MHz 19F NMR, in a Brucker AC 300E spectrometer for SLIL detection. All experiments were carried out in duplicate. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
90% | With hydroxyapatite supported copper(I) oxide; In acetonitrile; at 50℃; for 0.0666667h; | General procedure: A mixture of alcohol or phenol (1 mmol), acetyl chloride(1 mmol), hydroxyapatite -Cu2O (0.1 g) in acetonitrilewas taken in a round-bottom flask and stirred at 50 C foran appropriate time. On completion (monitored by TLC),the reaction mixture was cooled to room temperature andfiltered. The residue was washed with water followed byEtOAc (3 × 10 mL). The product was obtained after theremoval of solvent under reduced pressure followed bycrystallization from pet ether or EtOAc:pet ether or passingthrough column of silica and elution with EtOAc:pet ether. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With potassium hydroxide; In dimethyl sulfoxide; | Example E7 4-Iodo-5-(4-methoxy-benzyloxy)-2-nitro-phenylamine Prepared from <strong>[335349-57-0]5-chloro-4-iodo-2-nitro-phenylamine</strong> (Example Al) (5.97 g, 20 mmol), 4-methoxybenzyl alcohol (4.98 mL, 40 mmol) and KOH (1.58 g, 24 mmol) in DMSO (30 mL) at 23 C. according to the general procedure E. Obtained as a yellow-brown solid (2.94 g). MS (ISN) 399 [(M-H)-]; mp 183 C. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
In dichloromethane; | After 2.0 g of p-anise alcohol was reacted with 2.0 g of acetyl bromide in dichloromethane, the solvent was distilled off. 2.5 g of the resulting compound was dissolved in N,N-dimethylformamide, and 1.6 g of the compound represented by the formula (a) was added thereto, followed by the reaction in the presence of triethylamine. Then, 0.6 g of 4-(6-acryloyloxyhexyloxy)benzoic acid was added, followed by the reaction in the presence of 1-ethyl-3-(3'-dimethylaminopropyl)carbodiimide hydrochloride. After the solvent was distilled off, the resulting crude product was dissolved in anisole, and trifluoroacetic acid was added, followed by the reaction. Finally, the solvent was distilled off, followed by washing with hexane to obtain 0.1 g of an azo compound represented by the formula (c): |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
99% | With tetraethylammonium bicarbonate; at 60℃; for 2h; | General procedure: In a typical procedure, in a capped vessel alcohol 3a (0.5 mmol) and ester 2a (1.5 mmol) were added sequentially to the TEAHC (35.0 mg, 0.15 mmol); the reaction mixture was stirred for 2 h at 60 C and then transferred in a round-bottomed flask and concentrated under reduced pressure. The residue mixture was then extracted with diethyl ether (3 times with 10 cm3). After removal of the solvent from the combined ethereal layers under reduced pressure, the crude reaction mixture was analyzed by 1H and 13C NMR and thin-layer chromatography (TLC). All products were purified by using flash chromatography (n-hexane / ethyl acetate, 95/5) and identified on the basis of NMR spectroscopic analysis by comparison with reported data. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
33% | With potassium tert-butylate; In tetrahydrofuran; at 50℃; for 16h;Inert atmosphere; | General procedure: To a mixture of dichloride 21 (0.625 g, 2.7 mmol) and potassium tert-butoxide (0.395 g, 4.1 mmol) was added a solution of para-methoxybenzyl alcohol (0.568 g, 4.1 mmol) in THF (8 mL). Reaction mixture was heated to 50 C overnight. Reaction mixture was filtered and concentrated under reduced pressure. Product was purified via automated chromatography (EtOAc: Hexanes, 20:80) to provide 22 as a clear oil in 33% yield. 1H NMR (400 MHz, CDCl3) delta 8.38 (s, 1H), 7.30 (d, J = 8.6 Hz, 1H), 6.83 (d, J = 8.6 Hz, 1H), 5.38 (s, 2H), 3.73 (s, 3H). 13C NMR (101 MHz, CDCl3) delta 166.68, 160.23, 159.85, 155.22, 130.28, 130.16, 130.00, 127.24, 114.02, 106.27, 70.10, 55.32. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
73% | 3,5-Bis(4-methoxybenzyloxy)pyridine-2-carbonitrile (12). Sodium hydride (60percent, 3.66 g, 91.5 mmol) was added to 4-methoxybenzyl alcohol (11.5 mL, 92.6 mmol) in DMF (89 mL). The reaction mixture was stirred for 50 min and was cooled in an ice water bath, followed by addition of 11 (5.13 g, 36.6 mmol). After stirring at room temperature for 30 min and heating at 95-100 °C for 18 h, the reaction was quenched at 0 °C with EtOH and was concentrated by rotary evaporation under high vacuum. The residue was treated with H2O (250 mL) and extracted with warm EtOAc (400 mL, 2 × 100 mL). The organic extracts were washed with saturated NaCl (150 mL). Purification by flash column chromatography using 2percent acetone/CH2Cl2 gave 10.11 g of 12 (73percent) as a white solid, mp 122-122.5 °C: 1H NMR 3.81 (s, 3 H), 3.82 (s, 3 H), 5.04 (s, 2 H), 5.11 (s, 2 H), 6.85 (d, 1 H, J = 2.0), 6.92 (dd, 4 H, J = 8.6, 6.6), 7.31 (d, 4 H, J = 8.6), 8.01 (d, 1 H, J = 2.0). 13C NMR 55.44, 55.47, 70.98, 71.00, 106.86, 114.41, 115.63, 116.26, 126.83, 126.94, 129.04, 129.56, 131.98, 158.41, 159.10, 160.00, 160.14. HRMS m/z calculated for C22H21N2O4, 377.1496 (M + H); found: 377.1500. Anal. (C22H20N2O4) C, H, N. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
86%; 6% | With N-Bromosuccinimide; triphenylphosphine; In acetonitrile; at 20℃; for 1.9h;Cooling with ice; | General procedure: To a solution of Ph3P(OAc)2, was added 3-phenylpropanol (1 mmol, 0.137 mL). The progress of the reaction was monitored by TLC (Table 3, entry 2). After completion of the reaction (0.3 h) the reaction mixture was filtered to remove the precipitated NH4Br followed by evaporation of the solvent. Column chromatography of the crude mixture on silica gel using n-hexane/EtOAc (3:1) as the eluent gave 3-phenylpropyl acetate in 90% yield (0.159 g). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
9.85% | In tetrahydrofuran; ethyl acetate; | Step 1. N-methoxy-2-((4-methoxybenzyl)oxy)-N-methylacetamide To a suspension of sodium hydride (1.86 g, 46.5 mmol) in THF (80 ml) at 0° C. was added (4-methoxyphenyl)methyl alcohol (5.80 mL, 46.7 mmol) over 5 min. The reaction mixture was warmed to RT for 1 h, then cooled to 0° C. and a solution of <strong>[67442-07-3]2-chloro-N-methoxy-N-methylacetamide</strong> (6.50 g, 47.3 mmol) in THF (20 mL) was added. The reaction mixture was warmed to room temperature and stirred for 72 hr then quenched with NH4Cl and diluted with EtOAc and water. The aqueous phase was extracted with EtOAc (2*) and the combined organic extracts were washed with brine (1*), dried over MgSO4, filtered, and concentrated. Purification by flash column chromatography on silica gel (120 g, 30percent to 80percent EtOAc in hexanes) gave N-methoxy-2-((4-methoxybenzyl)oxy)-N-methylacetamide (1.10 g, 4.60 mmol, 9.85percent yield) as a yellow oil. ESI (M+Na) 262.1. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
204 mg | With sodium hydride; In water; mineral oil; at 0 - 5℃; for 2h;Inert atmosphere; | Example 0762 0762-1 60% sodium hydride (136 mg) was added to a mixture of <strong>[1309774-03-5]7-bromo-2-chloro-1,5-naphthyridine</strong> (300 mg), (4-methoxyphenyl)methanol, and N-methylpyrrolidone (12.3 mL) at a temperature of from 0 C. to 5 C., followed by stirring at room temperature for 2 hours in a nitrogen atmosphere. After water and ethyl acetate were added to the reaction mixture, the organic layer was washed sequentially with 0.01 mol/L hydrochloric acid and with a saturated sodium chloride aqueous solution, and dried over anhydrous sodium sulfate, and the solvent was distilled off under reduced pressure. The obtained residue was purified by silica gel column chromatography (ethyl acetate-hexane), thereby obtaining 7-bromo-2-((4-methoxybenzyl)oxy)-1,5-naphthyridine (204 mg) as a white solid. MS m/z (M+H): 345. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
94% | With 3-((3-(trisilyloxy)propyl)propionamide)-1-methylimidazolium chloride ionic liquid supported on magnetic nanoparticle Fe2O3; at 20℃; for 0.383333h; | General procedure: To a stirred solution of 4-bromobenzylalcohol (1 mmol, 0.185 g) in freshly acetic anhydride (2mmol, 0.19mL) TPPA-IL-Fe3O4 (10 mg) was added and the reaction mixture was stirred at room temperature for 20 min. The reaction progress was monitored by TLC (acetone: n-hexane, 2:8). After completion of the reaction, the catalyst was separated by an external magnet and the mixture was diluted with CH2Cl2. The organic layer was washed with NaHCO3 (5 mL) solution and water, then dried over anhydrous Na2SO4. Finally, the organic solvents were evaporated and 4-bromobenzyl acetate was obtained in 96% yield. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
41% | With 1,1'-bis-(diphenylphosphino)ferrocene; In toluene; at 150℃; for 24h;Inert atmosphere; | To a solution of <strong>[76361-99-4]3-bromo-2-nitro-phenol</strong> (120 mg, 0.550 mmol) in toluene (1.4 mL) was added (4-methoxyphenyl)methanol (190 mg, 1.38 mmol) and 1,1?- bis(diphenylphosphino)ferrocene (9.2 mg, 0.0 16 mmol). The mixture was stirred at 150 C for 24 h in a sealed vial under a nitrogen atmosphere. The reaction mixture was then cooled to roomtemperature, diluted with dichloromethane (10 mL), filtered through celite and concentrated in vacuo. The mixture obtained was purified by silica gel chromatography (acetone / heptane = 1 19 to 1: 9) to give the title compound (69.2 mg, 41%) as a pink solid. ?H NIVIR (400 MHz, DMSO-d6) 8.29- 8.20 (m, 2H), 7.50 (d, J = 8.0 Hz, 2H), 7.19 (t, J = 8.0 Hz, 1H), 7.07 -6.98 (m, 2H), 3.90 (s, 3H). LCMS IVJIZ (M+H) 305. |
Tags: 105-13-5 synthesis path| 105-13-5 SDS| 105-13-5 COA| 105-13-5 purity| 105-13-5 application| 105-13-5 NMR| 105-13-5 COA| 105-13-5 structure
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P380 | Evacuate area. |
P381 | Eliminate all ignition sources if safe to do so. |
P390 | Absorb spillage to prevent material damage. |
P391 | Collect spillage. Hazardous to the aquatic environment |
P301 + P310 | IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. |
P301 + P312 | IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. |
P301 + P330 + P331 | IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. |
P302 + P334 | IF ON SKIN: Immerse in cool water/wrap in wet bandages. |
P302 + P350 | IF ON SKIN: Gently wash with plenty of soap and water. |
P303 + P361 + P353 | IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. |
P304 + P312 | IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell. |
P304 + P340 | IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. |
P304 + P341 | IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing. |
P305 + P351 + P338 | IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. |
P306 + P360 | IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes. |
P307 + P311 | IF exposed: call a POISON CENTER or doctor/physician. |
P308 + P313 | IF exposed or concerned: Get medical advice/attention. |
P309 + P311 | IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician. |
P332 + P313 | IF SKIN irritation occurs: Get medical advice/attention. |
P333 + P313 | IF SKIN irritation or rash occurs: Get medical advice/attention. |
P335 + P334 | Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages. |
P337 + P313 | IF eye irritation persists: Get medical advice/attention. |
P342 + P311 | IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician. |
P370 + P376 | In case of fire: Stop leak if safe to Do so. |
P370 + P378 | In case of fire: |
P370 + P380 | In case of fire: Evacuate area. |
P370 + P380 + P375 | In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion. |
P371 + P380 + P375 | In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion. |
Storage | |
Code | Phrase |
P401 | |
P402 | Store in a dry place. |
P403 | Store in a well-ventilated place. |
P404 | Store in a closed container. |
P405 | Store locked up. |
P406 | Store in corrosive resistant/ container with a resistant inner liner. |
P407 | Maintain air gap between stacks/pallets. |
P410 | Protect from sunlight. |
P411 | |
P412 | Do not expose to temperatures exceeding 50 oC/ 122 oF. |
P413 | |
P420 | Store away from other materials. |
P422 | |
P402 + P404 | Store in a dry place. Store in a closed container. |
P403 + P233 | Store in a well-ventilated place. Keep container tightly closed. |
P403 + P235 | Store in a well-ventilated place. Keep cool. |
P410 + P403 | Protect from sunlight. Store in a well-ventilated place. |
P410 + P412 | Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF. |
P411 + P235 | Keep cool. |
Disposal | |
Code | Phrase |
P501 | Dispose of contents/container to ... |
P502 | Refer to manufacturer/supplier for information on recovery/recycling |
Physical hazards | |
Code | Phrase |
H200 | Unstable explosive |
H201 | Explosive; mass explosion hazard |
H202 | Explosive; severe projection hazard |
H203 | Explosive; fire, blast or projection hazard |
H204 | Fire or projection hazard |
H205 | May mass explode in fire |
H220 | Extremely flammable gas |
H221 | Flammable gas |
H222 | Extremely flammable aerosol |
H223 | Flammable aerosol |
H224 | Extremely flammable liquid and vapour |
H225 | Highly flammable liquid and vapour |
H226 | Flammable liquid and vapour |
H227 | Combustible liquid |
H228 | Flammable solid |
H229 | Pressurized container: may burst if heated |
H230 | May react explosively even in the absence of air |
H231 | May react explosively even in the absence of air at elevated pressure and/or temperature |
H240 | Heating may cause an explosion |
H241 | Heating may cause a fire or explosion |
H242 | Heating may cause a fire |
H250 | Catches fire spontaneously if exposed to air |
H251 | Self-heating; may catch fire |
H252 | Self-heating in large quantities; may catch fire |
H260 | In contact with water releases flammable gases which may ignite spontaneously |
H261 | In contact with water releases flammable gas |
H270 | May cause or intensify fire; oxidizer |
H271 | May cause fire or explosion; strong oxidizer |
H272 | May intensify fire; oxidizer |
H280 | Contains gas under pressure; may explode if heated |
H281 | Contains refrigerated gas; may cause cryogenic burns or injury |
H290 | May be corrosive to metals |
Health hazards | |
Code | Phrase |
H300 | Fatal if swallowed |
H301 | Toxic if swallowed |
H302 | Harmful if swallowed |
H303 | May be harmful if swallowed |
H304 | May be fatal if swallowed and enters airways |
H305 | May be harmful if swallowed and enters airways |
H310 | Fatal in contact with skin |
H311 | Toxic in contact with skin |
H312 | Harmful in contact with skin |
H313 | May be harmful in contact with skin |
H314 | Causes severe skin burns and eye damage |
H315 | Causes skin irritation |
H316 | Causes mild skin irritation |
H317 | May cause an allergic skin reaction |
H318 | Causes serious eye damage |
H319 | Causes serious eye irritation |
H320 | Causes eye irritation |
H330 | Fatal if inhaled |
H331 | Toxic if inhaled |
H332 | Harmful if inhaled |
H333 | May be harmful if inhaled |
H334 | May cause allergy or asthma symptoms or breathing difficulties if inhaled |
H335 | May cause respiratory irritation |
H336 | May cause drowsiness or dizziness |
H340 | May cause genetic defects |
H341 | Suspected of causing genetic defects |
H350 | May cause cancer |
H351 | Suspected of causing cancer |
H360 | May damage fertility or the unborn child |
H361 | Suspected of damaging fertility or the unborn child |
H361d | Suspected of damaging the unborn child |
H362 | May cause harm to breast-fed children |
H370 | Causes damage to organs |
H371 | May cause damage to organs |
H372 | Causes damage to organs through prolonged or repeated exposure |
H373 | May cause damage to organs through prolonged or repeated exposure |
Environmental hazards | |
Code | Phrase |
H400 | Very toxic to aquatic life |
H401 | Toxic to aquatic life |
H402 | Harmful to aquatic life |
H410 | Very toxic to aquatic life with long-lasting effects |
H411 | Toxic to aquatic life with long-lasting effects |
H412 | Harmful to aquatic life with long-lasting effects |
H413 | May cause long-lasting harmful effects to aquatic life |
H420 | Harms public health and the environment by destroying ozone in the upper atmosphere |
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