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Chemical Structure| 1003581-82-5 Chemical Structure| 1003581-82-5

Structure of 1003581-82-5

Chemical Structure| 1003581-82-5

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Product Details of [ 1003581-82-5 ]

CAS No. :1003581-82-5
Formula : C9H8N2O3
M.W : 192.17
SMILES Code : O=C(OC)C1=C2C=CC(O)=CN2N=C1
MDL No. :MFCD26399366

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Application In Synthesis of [ 1003581-82-5 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1003581-82-5 ]

[ 1003581-82-5 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 1003581-82-5 ]
  • [ 194152-05-1 ]
  • methyl 6-((1,1-dioxidotetrahydro-2H-thiopyran-4-yl)oxy)pyrazolo[1,5-a]pyridine-3-carboxylate [ No CAS ]
YieldReaction ConditionsOperation in experiment
65% With tributylphosphine; 1,1'-azodicarbonyl-dipiperidine; In toluene; at 120℃; for 0.75h;Microwave irradiation; Methyl 6-hydroxypyrazoIo[i,5-aipyridine3-carboxyiate (0100 g, 0.520 mniol),4-hydroxvtetrahydro-2H-thiopyran 1.1 -dioxide (0.094 g. 062 mmol), and I ,i(azodicarbonyi)dipiperidine (0.328 g, 130 mmoi) were placed in a pressure vial. Then, anhydrous PhMe (4 rnL) and tri-Nbutyiphosphine (0325 rnL, 130 rnmoi) were added, and the reaction mixture was stirred at 120 °C under microwave irradiation for 45 mm,The reaction mixture Was quenched with MeOH (1 mL), diluted with EtOAc (50 mL), Celite was added, and solvent was removed under reduced pressure. The residue was purified by flash chromatography (solid loading, 0-100percent EtOAc/DCM gradient) to give methyl 6-(( 1,1 -dioxidotetrahydro-2H-thiopyran-4-yI)oxy)pyrazoio[ I ,5-a]pvridine-3- carboxylale (0.110 g, 65 percent yield) as a white solid. MS (ESI) m/z: 325.0 (M+]H)1. ?H-NMR: (500 MHz, DMSO-d6) ppm 8.84 (d, J=2.2 Hz, IH), 839 (s, 1H), 800 (ci, J=9.4 Hz, 11-1), 753 (dd, .J:9.6. 1.9 T-{z. IFI), 4.78 (qdri, .J::4.6 FIz. 1FI). 382 (s. 3H). 330 - 323 (m, 2H), 3.19 - 3.12 (m, 2H). 226 (q, J=5.4 Hz, 4H).
 

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