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Chemical Structure| 5439-08-7 Chemical Structure| 5439-08-7
Chemical Structure| 5439-08-7

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Methyl 3,5-dichloropicolinate

CAS No.: 5439-08-7

4.5 *For Research Use Only !

Cat. No.: A192251 Purity: 98%

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Product Details of [ 5439-08-7 ]

CAS No. :5439-08-7
Formula : C7H5Cl2NO2
M.W : 206.03
SMILES Code : COC(=O)C1=NC=C(Cl)C=C1Cl
MDL No. :MFCD09839147
InChI Key :SBQBPKUDXAELAZ-UHFFFAOYSA-N
Pubchem ID :225523

Safety of [ 5439-08-7 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Application In Synthesis [ 5439-08-7 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 5439-08-7 ]

[ 5439-08-7 ] Synthesis Path-Downstream   1~3

  • 2
  • [ 81719-53-1 ]
  • [ 18107-18-1 ]
  • [ 5439-08-7 ]
YieldReaction ConditionsOperation in experiment
In methanol; toluene; at 20℃; for 1h; <strong>[81719-53-1]3,5-dichloropicolinic acid</strong> (1.0 equiv.) was dissolved in 5:1 toluene: methanol (0.5 M) and then TMS-diazomethane (1.2 equiv.) was added dropwise. The reaction mixture was agitated at room temperature for 1 h and quenched by addition of glacial acetic acid drop-wise until the effervescence had subsided and concentrated in vacuo and the residue was triturated with heptane and the dark brown precipitate methyl 3,5-dichloropicolinate was collected by filtration. LCMS (m/z) (M+H) = 205.9, Rt =1.18 mm.
  • 3
  • [ 67-56-1 ]
  • [ 81719-53-1 ]
  • [ 5439-08-7 ]
YieldReaction ConditionsOperation in experiment
93.4% With sulfuric acid; at 65℃; for 6h; The compound <strong>[81719-53-1]3,5-dichloro-2-pyridinecarboxylic acid</strong> (38.4g), concentrated sulfuric acid (3.8mL), methanol (384mL) was added to the reaction flask at room temperature, the temperature was controlled at 65 C, and the reaction was refluxed for 6h. It was concentrated to dryness under reduced pressure at 40 C, washed twice with water, and dried to obtain 38.5g of methyl 3,5-dichloro-2-pyridinecarboxylate, with a yield of 93.4%.
 

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