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Chemical Structure| 1610964-64-1 Chemical Structure| 1610964-64-1

Structure of Unesbulin
CAS No.: 1610964-64-1

Chemical Structure| 1610964-64-1

Unesbulin

CAS No.: 1610964-64-1

PTC596 is an orally active and selective B-cell-specific Moloney murine leukemia virus integration site 1 (BMI-1) inhibitor. PTC596 targets BMI1 expressed by both tumor cells and cancer stem cells (CSCs), and induces hyper-phosphorylation of BMI1, leading to its degradation. PTC596 downregulates MCL-1 and induces p53-independent mitochondrial apoptosis in acute myeloid leukemia progenitor cells[1][2].

Synonyms: PTC596

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Cat. No.: A602809 Purity: 98+%

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Product Details of Unesbulin

CAS No. :1610964-64-1
Formula : C19H13F5N6
M.W : 420.34
SMILES Code : NC1=C(F)C(NC2=CC=C(C(F)(F)F)C=C2)=NC(N3C(C)=NC4=CC=C(F)C=C34)=N1
Synonyms :
PTC596
MDL No. :MFCD30489439
InChI Key :TWLWOOPCEXYVBE-UHFFFAOYSA-N
Pubchem ID :74223469

Safety of Unesbulin

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P280-P301+P312-P302+P352-P305+P351+P338

Related Pathways of Unesbulin

Hedgehog

Isoform Comparison

Biological Activity

Clinical Trial:

NCT Number Conditions Phases Recruitment Completion Date Locations
NCT03206645 Ovarian Cancer PHASE1 COMPLETED 2024-03-31 University of Oklahoma Health ... More >>Sciences Center, Oklahoma City, Oklahoma, 73104, United States Less <<
NCT02404480 Cancer PHASE1 COMPLETED 2017-02-06 Dana Farber Cancer Institute, ... More >>Boston, Massachusetts, 02215, United States|Duke University, Durham, North Carolina, 27708, United States|Sarah Cannon Research Institute, Nashville, Tennessee, 37203, United States|Princess Margaret Cancer Centre, Toronto, Ontario, M4Y2H8, Canada Less <<

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.38mL

0.48mL

0.24mL

11.90mL

2.38mL

1.19mL

23.79mL

4.76mL

2.38mL

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