38116-61-9|2-Hydroxy-6-methylpyridine-3-carboxylic acid| Ambeed

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Quality Control of [ 38116-61-9 ] Purity: 98% SDS Specification

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NMR

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Product Details of [ 38116-61-9 ]

CAS No. :	38116-61-9
Formula :	C₇H₇NO₃
M.W :	153.14
SMILES Code :	O=C(O)C1=C(O)N=C(C)C=C1
MDL No. :	MFCD00460503
InChI Key :	XRIHTJYXIHOBDQ-UHFFFAOYSA-N
Pubchem ID :	94960

Safety of [ 38116-61-9 ]

GHS Pictogram:
Signal Word:	Warning
Hazard Statements:	H319
Precautionary Statements:	P305+P351+P338

Computational Chemistry of [ 38116-61-9 ] Show Less

Physicochemical Properties

Num. heavy atoms	11
Num. arom. heavy atoms	6
Fraction Csp3	0.14
Num. rotatable bonds	1
Num. H-bond acceptors	4.0
Num. H-bond donors	2.0
Molar Refractivity	38.19
TPSA ? Topological Polar Surface Area: Calculated from Ertl P. et al. 2000 J. Med. Chem.	70.42 Å²

Lipophilicity

Log P_o/w (iLOGP)? iLOGP: in-house physics-based method implemented from Daina A et al. 2014 J. Chem. Inf. Model.	0.86
Log P_o/w (XLOGP3)? XLOGP3: Atomistic and knowledge-based method calculated by XLOGP program, version 3.2.2, courtesy of CCBG, Shanghai Institute of Organic Chemistry	1.31
Log P_o/w (WLOGP)? WLOGP: Atomistic method implemented from Wildman SA and Crippen GM. 1999 J. Chem. Inf. Model.	0.79
Log P_o/w (MLOGP)? MLOGP: Topological method implemented from Moriguchi I. et al. 1992 Chem. Pharm. Bull. Moriguchi I. et al. 1994 Chem. Pharm. Bull. Lipinski PA. et al. 2001 Adv. Drug. Deliv. Rev.	-0.96
Log P_o/w (SILICOS-IT)? SILICOS-IT: Hybrid fragmental/topological method calculated by FILTER-IT program, version 1.0.2, courtesy of SILICOS-IT, http://www.silicos-it.com	0.7
Consensus Log P_o/w? Consensus Log P_o/w: Average of all five predictions	0.54

Water Solubility

Log S (ESOL):? ESOL: Topological method implemented from Delaney JS. 2004 J. Chem. Inf. Model.	-1.95
Solubility	1.71 mg/ml ; 0.0112 mol/l
Class? Solubility class: Log S scale Insoluble < -10 < Poorly < -6 < Moderately < -4 < Soluble < -2 Very < 0 < Highly	Very soluble
Log S (Ali)? Ali: Topological method implemented from Ali J. et al. 2012 J. Chem. Inf. Model.	-2.39
Solubility	0.625 mg/ml ; 0.00408 mol/l
Class? Solubility class: Log S scale Insoluble < -10 < Poorly < -6 < Moderately < -4 < Soluble < -2 Very < 0 < Highly	Soluble
Log S (SILICOS-IT)? SILICOS-IT: Fragmental method calculated by FILTER-IT program, version 1.0.2, courtesy of SILICOS-IT, http://www.silicos-it.com	-1.19
Solubility	9.8 mg/ml ; 0.064 mol/l
Class? Solubility class: Log S scale Insoluble < -10 < Poorly < -6 < Moderately < -4 < Soluble < -2 Very < 0 < Highly	Soluble

Pharmacokinetics

GI absorption? Gatrointestinal absorption: according to the white of the BOILED-Egg	High
BBB permeant? BBB permeation: according to the yolk of the BOILED-Egg	No
P-gp substrate? P-glycoprotein substrate: SVM model built on 1033 molecules (training set) and tested on 415 molecules (test set) 10-fold CV: ACC=0.72 / AUC=0.77 External: ACC=0.88 / AUC=0.94	No
CYP1A2 inhibitor? Cytochrome P450 1A2 inhibitor: SVM model built on 9145 molecules (training set) and tested on 3000 molecules (test set) 10-fold CV: ACC=0.83 / AUC=0.90 External: ACC=0.84 / AUC=0.91	No
CYP2C19 inhibitor? Cytochrome P450 2C19 inhibitor: SVM model built on 9272 molecules (training set) and tested on 3000 molecules (test set) 10-fold CV: ACC=0.80 / AUC=0.86 External: ACC=0.80 / AUC=0.87	No
CYP2C9 inhibitor? Cytochrome P450 2C9 inhibitor: SVM model built on 5940 molecules (training set) and tested on 2075 molecules (test set) 10-fold CV: ACC=0.78 / AUC=0.85 External: ACC=0.71 / AUC=0.81	No
CYP2D6 inhibitor? Cytochrome P450 2D6 inhibitor: SVM model built on 3664 molecules (training set) and tested on 1068 molecules (test set) 10-fold CV: ACC=0.79 / AUC=0.85 External: ACC=0.81 / AUC=0.87	No
CYP3A4 inhibitor? Cytochrome P450 3A4 inhibitor: SVM model built on 7518 molecules (training set) and tested on 2579 molecules (test set) 10-fold CV: ACC=0.77 / AUC=0.85 External: ACC=0.78 / AUC=0.86	No
Log Kp (skin permeation)? Skin permeation: QSPR model implemented from Potts RO and Guy RH. 1992 Pharm. Res.	-6.3 cm/s

Druglikeness

Lipinski? Lipinski (Pfizer) filter: implemented from Lipinski CA. et al. 2001 Adv. Drug Deliv. Rev. MW ≤ 500 MLOGP ≤ 4.15 N or O ≤ 10 NH or OH ≤ 5	0.0
Ghose? Ghose filter: implemented from Ghose AK. et al. 1999 J. Comb. Chem. 160 ≤ MW ≤ 480 -0.4 ≤ WLOGP ≤ 5.6 40 ≤ MR ≤ 130 20 ≤ atoms ≤ 70	None
Veber? Veber (GSK) filter: implemented from Veber DF. et al. 2002 J. Med. Chem. Rotatable bonds ≤ 10 TPSA ≤ 140	0.0
Egan? Egan (Pharmacia) filter: implemented from Egan WJ. et al. 2000 J. Med. Chem. WLOGP ≤ 5.88 TPSA ≤ 131.6	0.0
Muegge? Muegge (Bayer) filter: implemented from Muegge I. et al. 2001 J. Med. Chem. 200 ≤ MW ≤ 600 -2 ≤ XLOGP ≤ 5 TPSA ≤ 150 Num. rings ≤ 7 Num. carbon > 4 Num. heteroatoms > 1 Num. rotatable bonds ≤ 15 H-bond acc. ≤ 10 H-bond don. ≤ 5	1.0
Bioavailability Score? Abbott Bioavailability Score: Probability of F > 10% in rat implemented from Martin YC. 2005 J. Med. Chem.	0.56

Medicinal Chemistry

PAINS? Pan Assay Interference Structures: implemented from Baell JB. & Holloway GA. 2010 J. Med. Chem.	0.0 alert
Brenk? Structural Alert: implemented from Brenk R. et al. 2008 ChemMedChem	0.0 alert: heavy_metal
Leadlikeness? Leadlikeness: implemented from Teague SJ. 1999 Angew. Chem. Int. Ed. 250 ≤ MW ≤ 350 XLOGP ≤ 3.5 Num. rotatable bonds ≤ 7	No; 1 violation:MW<1.0
Synthetic accessibility? Synthetic accessibility score: from 1 (very easy) to 10 (very difficult) based on 1024 fragmental contributions (FP2) modulated by size and complexity penaties, trained on 12'782'590 molecules and tested on 40 external molecules (r² = 0.94)	1.49

Application In Synthesis of [ 38116-61-9 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Downstream synthetic route of [ 38116-61-9 ]

[ 38116-61-9 ] Synthesis Path-Downstream 1~35

1
[ 186581-53-3 ]
[ 38116-61-9 ]
[ 51146-06-6 ]

References: [1]Journal of the American Chemical Society,1952,vol. 74,p. 1915.

2
[ 4241-27-4 ]
[ 38116-61-9 ]

References: [1]Chemische Berichte,1940,vol. 73,p. 156.

3
[ 67-56-1 ]
[ 38116-61-9 ]
[ 51146-06-6 ]

Yield	Reaction Conditions	Operation in experiment
64.1%	With sulfuric acid; at 0℃; for 21h;Reflux;	To a solution of <strong>[38116-61-9]2-hydroxy-6-methylnicotinic acid</strong> (10.0 g, 0.0653 mole) in methanol (100 mL), sulfuric acid (3.5 mL) was added drop wise at 0 C and the mixture was stirred for 21 h under reflux. The reaction mixture was concentrated under reduced pressure, the residue was neutralized with saturated aqueous sodium bicarbonate solution under ice-cooling, and the mixture was extracted with 5 % methanol in chloroform (200 mL x 3). Organic layer was washed with brine solution (50 mL) and dried over Na2S04 and the solvent was concentrated under vacuum to afford the title compound. (0233) Yield: 7.0 g, 64.1%; 1H - NMR (DMSO- 6, 400 MHz) d ppm: 2.23 (s, 3H), 3.70 (s, 3H), 6.09 - 6.11 (d, J = 7.24 Hz, 1H), 7.98 - 8.00 (d, J = 7.36 Hz, 1H), 12.10 (s, 1H); Mass (m/z): 168.1 (M+H)+.

References: [1]Patent: WO2019/102365,2019,A1 .Location in patent: Page/Page column 24.
[2]Archiv der Pharmazie,1957,vol. 290,p. 61,65.

4
[ 38116-61-9 ]
2-hydroxyl-3-hydroxymethyl-6-methylpyridine [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
38 g	With lithium aluminium tetrahydride; In tetrahydrofuran; at 70℃; for 1h;Inert atmosphere;	Reference Production Example 40 (0661) To a mixture of 50.0 g of <strong>[38116-61-9]2-hydroxy-6-methylnicotinic acid</strong> and 500 ml tetrahydrofuran, 18.6 g of lithium aluminum hydride was added in a nitrogen atmosphere at 70 C. for 1 hour. To the reaction mixture, 19 ml of water was added dropwise under ice cooling, followed by stirring at 0 C. for 1 hour. Furthermore, 16 ml of an aqueous 15% sodium oxide solution was added dropwise, followed by stirring at room temperature for 1 hour. The reaction mixture was filtered through Cerite and the filtrate was concentrated under reduced pressure to obtain 38.0 g of 2-hydroxy-3-hydroxymethyl-6-methylpyridine (hereinafter referred to as 40A). (0662) 1H-NMR (DMSO-D6) delta:6.82 (1H, d, J=6.8 Hz), 5.83 (1H, d, J=6.8 Hz), 4.25 (2H, s), 2.06 (3H, s).
38 g	With lithium hydroxide; In tetrahydrofuran; at 70℃; for 1h;Inert atmosphere;	In the 70 C, to 50.0g of 2-hydroxy-6-methyl-nicotinic acid and 500 ml mixture of tetrahydrofuran, is added in the nitrogen atmosphere 18.6g alchlor hydrogenation of 1 hour. Frozen under the, dropping to the reaction mixture 19 ml of water, then in the 0 C stirring 1 hour. Furthermore, dropping 16 ml of a 15% sodium hydroxide aqueous solution, followed by stirring at room temperature 1 hour. The reaction mixture is filtered through a Cerite, and the filtrate concentrated under reduced pressure, to obtain 38.0g of 2-hydroxy-3-hydroxymethyl-6-methylpyridine (called below 40A).

References: [1]Journal of the American Chemical Society,1952,vol. 74,p. 1915.
[2]Patent: US2016/157489,2016,A1 .Location in patent: Paragraph 0661; 0662.
[3]Patent: CN105492432,2016,A .Location in patent: Paragraph 1055; 1056; 1057; 1058.

5
[ 38116-61-9 ]
[ 51146-06-6 ]

References: [1]Archiv der Pharmazie,1957,vol. 290,p. 61,65.

6
[ 38116-61-9 ]
[ 64-17-5 ]
[ 51146-04-4 ]

Yield	Reaction Conditions	Operation in experiment
27%	With hydrogenchloride; In 1,4-dioxane; for 16h;Reflux;	Preparation 211ethyl 2-hydroxy-6-methylpyridine-3-carboxylate To a solution of <strong>[38116-61-9]2-hydroxy-6-methylpyridine-3-carboxylic acid</strong> (2.0 g, 13.06 mmol) in ethanol (20 mL), was added HCI in dioxane (10 mL) dropwise and the reaction was refluxed for 16 hours. The reaction was concentrated in vacuo and basified with saturated aqueous sodiumbicarbonate solution. The mixture was extracted with ethyl acetate (twice), the organic layers were combined, washed with water, brine, dried over sodium sulfate and concentrated in vacuo to afford the title compound as a white solid (650 mg, 27%). 1H NMR (400 MHz, DMSO-d6): O ppm 1.24 (t, 3H), 2.22 (s, 3H), 4.16 (q, 2H), 6.08 (d, 1H), 7.97(d, 1H).

References: [1]Patent: WO2015/92610,2015,A1 .Location in patent: Page/Page column 200; 201.
[2]Heterocycles,1993,vol. 35,p. 93 - 97.

7
[ 38116-61-9 ]
[ 39853-81-1 ]

References: [1]Journal of Medicinal Chemistry,1991,vol. 34,p. 2993 - 3006.

8
[ 38116-61-9 ]
[ 117449-75-9 ]

Yield	Reaction Conditions	Operation in experiment
		EXAMPLE 1; Step A:; A solution of NaOCl (1.2 L, of 5%) was cooled to 0 0C in ice bath. 2-hydroxy-6- methylpyrridine-3-carboxylic acid 1-1 (100 g, 0.65mol) was added in small portions. The resulting homogenous mixture was stirred at 0 0C for 1 hour and then at 1O0C for 5 hours. Another portion NaOCl(300 mL, of 5%) was added at O0C and the mixture was stirred at 100C overnight. The solution was acidified to pH = 1 with 12N HCl, and the resulting solid was filtered, washed with water, and oven dried to afford white solid product 1-2 (m/z (ES) (M+H)+= 188).

References: [1]Journal of Medicinal Chemistry,1989,vol. 32,p. 2178 - 2199.
[2]Patent: WO2007/41052,2007,A2 .Location in patent: Page/Page column 86-88.

9
[ 38116-61-9 ]
[ 100-51-6 ]
[ 147269-61-2 ]

References: [1]Journal of Organic Chemistry,2002,vol. 67,p. 741 - 746.
[2]Bioorganic and Medicinal Chemistry Letters,1997,vol. 7,p. 1497 - 1500.

10
[ 38116-61-9 ]
[ 100-51-6 ]
[ 147269-61-2 ]

Yield	Reaction Conditions	Operation in experiment
56%		Diphenylphosphoryl azide (11.9 mL, 55 mmol) was added to a solution of <strong>[38116-61-9]2-hydroxy-6-methylpyridine-3-carboxylic acid</strong> (7.65 g, 50 mmol) and triethylamine (7.7 mL, 55 mmol) in dry dioxane (100 mL) and the resulting solution was heated to reflux. After 16 h more triethylamine (7.7 mL, 55 mmol) and benzyl alcohol (5.7 mL, 50 mmol) were added and the solution was refluxed for a further 24 h. The reaction mixture was concentrated in vacuo and the residue was partitioned between methylene chloride (200 mL) and brine (100 mL), acidified to pH 1 with 10% HCl. The organic layer was washed with saturated NaHCO3 (2×100 mL), brine (100 mL), dried over Na2SO4 and filtered. After evaporating the solvent in vacuo, methanol (100 mL) and hexane (20 mL) were added to the residue, the solid was collected, washed with methanol (50 mL) and dried to give the title compound as a white solid (7.2 g, 56%). 1H-NMR (300 MHz, CDCl3) delta12.82 (s, 1H), 8.06 (d, J=7.0 Hz, 1H),7.69 (s, 1H), 7.42 (m, 5H), 6.09 (d, J=7.5 Hz, 1H), 5.22 (s, 2H), 2.32 (s, 3H).

References: [1]Patent: US6350764,2002,B2 .Location in patent: Page column 40.
[2]Journal of Medicinal Chemistry,1998,vol. 41,p. 4466 - 4474.

12
2-amino-6-methyl-pyridine-nicotinic acid [ No CAS ]
[ 38116-61-9 ]

References: [1]Chemische Berichte,1940,vol. 73,p. 542,546.

13
[ 38116-61-9 ]
[ 75-36-5 ]
[ 51146-06-6 ]

Yield	Reaction Conditions	Operation in experiment
100%	In methanol;	Step A Methyl-2-hydroxy-6-methylpyridine-3-carboxylate Acetyl chloride (50 ml) was added cautiously to a stirred suspension of <strong>[38116-61-9]2-hydroxy-6-methylpyridine-3-carboxylic acid</strong> (14.3 g, 93.44 mmol) in dry methanol (500 ml) and the resulting solution was heated to reflux. After 16 h the solution was evaporated in vacuo to give the title compound (15.62 g, 100%) as a solid: 1 H NMR (DMSO) shows the methyl singlet at delta 3.71.

References: [1]Patent: US5668289,1997,A .

14
[ 67-56-1 ]
[ 38116-61-9 ]
[ 885277-48-5 ]

Yield	Reaction Conditions	Operation in experiment
79%		Phosphorus oxybromide (21.53 g, 75 mmol) was added to the stirred solution of 2-hydroxy-6- methylnicotinic acid (5 g, 32.7 mmol), pyridine (0.475 mL, 5.88 mmol) in chlorobenzene (100 mL) at room temperature under nitrogen. The reaction mixture was refluxed for 1 h and concentrated under vacuum before treating with an excess of cold methanol. The solution was stirred for an additional 1 h and again concentrated under vacuum. The residue was dissolved in water and pH was adjusted to ~8.0 by adding K2CO3 before extraction of the product with CH2CI2. The organic layer was washed with water and brine solution, dried over anhydrous Na2S04. Filtrate was evaporated completely under reduced pressure to give crude residue. The resulted crude compound was purified by flash column chromatography (100-200 silica mesh, eluent was 30% EtOAc in pet ether) to obtained methyl 2-bromo-6-methylnicotinate (6.1 g, 79% yield) as colorless oil. 1H NMR (400 MHz, CDCI3): d 8.00 (d, /= 7.6 Hz, 1H), 7.18 (d, J = 8.0 Hz, 1H), 3.94 (s, 3H), 2.59 (s, 3H); LCMS (ES) m/z 230.0 (M+H)+

References: [1]Patent: WO2019/149959,2019,A1 .Location in patent: Page/Page column 60.
[2]Tetrahedron,2005,vol. 61,p. 4569 - 4576.

15
Fmoc-D,L-Hcy(Trt)-OH [ No CAS ]
[ 38116-61-9 ]
[ 86123-10-6 ]
2-{2-[(2-hydroxy-6-methyl-pyridine-3-carbonyl)-amino]-4-mercapto-butyrylamino}-3-phenyl-propionic acid [ No CAS ]

References: [1]Bioorganic and Medicinal Chemistry Letters,2006,vol. 16,p. 5169 - 5175.

16
[ 38116-61-9 ]
[ 853179-76-7 ]

References: [1]Tetrahedron,2005,vol. 61,p. 4569 - 4576.
[2]Patent: WO2019/149959,2019,A1 .

17
[ 38116-61-9 ]
[ 853179-88-1 ]

References: [1]Tetrahedron,2005,vol. 61,p. 4569 - 4576.
[2]Patent: WO2019/149959,2019,A1 .

18
[ 38116-61-9 ]
[ 173064-91-0 ]

References: [1]Tetrahedron,2005,vol. 61,p. 4569 - 4576.
[2]Patent: WO2019/149959,2019,A1 .

19
[ 38116-61-9 ]
(1,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)carbamic acid benzyl ester [ No CAS ]

References: [1]Journal of Organic Chemistry,2002,vol. 67,p. 741 - 746.

20
[ 38116-61-9 ]
[ 147269-63-4 ]

References: [1]Journal of Medicinal Chemistry,1998,vol. 41,p. 4466 - 4474.

21
[ 38116-61-9 ]
[ 179524-33-5 ]

References: [1]Journal of Medicinal Chemistry,1998,vol. 41,p. 4466 - 4474.
[2]Bioorganic and Medicinal Chemistry Letters,1997,vol. 7,p. 1497 - 1500.

22
[ 38116-61-9 ]
[ 179524-34-6 ]

References: [1]Journal of Medicinal Chemistry,1998,vol. 41,p. 4466 - 4474.
[2]Bioorganic and Medicinal Chemistry Letters,1997,vol. 7,p. 1497 - 1500.

23
[ 38116-61-9 ]
[ 179523-60-5 ]

References: [1]Journal of Medicinal Chemistry,1998,vol. 41,p. 4466 - 4474.
[2]Bioorganic and Medicinal Chemistry Letters,1997,vol. 7,p. 1497 - 1500.

24
[ 38116-61-9 ]
[ 179524-35-7 ]

References: [1]Journal of Medicinal Chemistry,1998,vol. 41,p. 4466 - 4474.
[2]Bioorganic and Medicinal Chemistry Letters,1997,vol. 7,p. 1497 - 1500.

25
[ 38116-61-9 ]
3-(2-phenethylamino)-6-methyl-1-(2-amino-6-methyl-5-methylenecarboxamidomethylpyridinyl)-2-pyridinone [ No CAS ]

References: [1]Journal of Medicinal Chemistry,1998,vol. 41,p. 4466 - 4474.

26
[ 38116-61-9 ]
L-374087 [ No CAS ]

References: [1]Journal of Medicinal Chemistry,1998,vol. 41,p. 4466 - 4474.

27
[ 38116-61-9 ]
[ 187237-49-6 ]

References: [1]Journal of Medicinal Chemistry,1998,vol. 41,p. 4466 - 4474.

28
[ 38116-61-9 ]
3-(2-phenethylamino)-6-methyl-1-(2-tert-butylcarbonylamino-6-methyl-5-methylenecarboxamidomethylpyridinyl)-2-pyridinone [ No CAS ]

References: [1]Journal of Medicinal Chemistry,1998,vol. 41,p. 4466 - 4474.

29
[ 38116-61-9 ]
(6-methyl-5-[2-(6-methyl-2-oxo-3-phenylmethanesulfonylamino-2<i>H</i>-pyridin-1-yl)-acetylamino]-methyl}-pyridin-2-yl)-carbamic acid <i>tert</i>-butyl ester [ No CAS ]

References: [1]Journal of Medicinal Chemistry,1998,vol. 41,p. 4466 - 4474.

30
[ 38116-61-9 ]
[ 216979-24-7 ]

References: [1]Journal of Medicinal Chemistry,1998,vol. 41,p. 4466 - 4474.

31
[ 38116-61-9 ]
[ 187163-89-9 ]

References: [1]Bioorganic and Medicinal Chemistry Letters,1997,vol. 7,p. 1497 - 1500.

32
[ 38116-61-9 ]
L-373890 [ No CAS ]

References: [1]Bioorganic and Medicinal Chemistry Letters,1997,vol. 7,p. 1497 - 1500.

33
[ 38116-61-9 ]
4-[2-(6-Methyl-2-oxo-3-phenylmethanesulfonylamino-2H-pyridin-1-yl)-acetylamino]-methyl}-piperidine-1-carboxylic acid tert-butyl ester [ No CAS ]

References: [1]Bioorganic and Medicinal Chemistry Letters,1997,vol. 7,p. 1497 - 1500.

34
[ 38116-61-9 ]
[ 117449-74-8 ]

References: [1]Journal of Medicinal Chemistry,1989,vol. 32,p. 2178 - 2199.

35
[ 38116-61-9 ]
[ 117450-13-2 ]

References: [1]Journal of Medicinal Chemistry,1989,vol. 32,p. 2178 - 2199.

Historical Records

Technical Information

• Appel Reaction • Arndt-Eistert Homologation • Buchwald-Hartwig C-N Bond and C-O Bond Formation Reactions • Chugaev Reaction • Corey-Kim Oxidation • Dess-Martin Oxidation • Hunsdiecker-Borodin Reaction • Hydride Reductions • Jones Oxidation • Martin's Sulfurane Dehydrating Reagent • Mitsunobu Reaction • Moffatt Oxidation • Oxidation of Alcohols by DMSO • Passerini Reaction • Preparation of Alcohols • Preparation of Amines • Preparation of Carboxylic Acids • Reactions of Alcohols • Reactions of Amines • Reactions of Carboxylic Acids • Reactions with Organometallic Reagents • Ritter Reaction • Schmidt Reaction • Sharpless Olefin Synthesis • Specialized Acylation Reagents-Ketenes • Swern Oxidation • Ugi Reaction

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P336	Thaw frosted parts with lukewarm water. Do not rub affected area.
P337	If eye irritation persists:
P338	Remove contact lenses, if present and easy to do. Continue rinsing.
P340	Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P341	If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P342	If experiencing respiratory symptoms:
P350	Gently wash with plenty of soap and water.
P351	Rinse cautiously with water for several minutes.
P352	Wash with plenty of soap and water.
P353	Rinse skin with water/shower.
P360	Rinse immediately contaminated clothing and skin with plenty of water before removing clothes.
P361	Remove/Take off immediately all contaminated clothing.
P362	Take off contaminated clothing and wash before reuse.
P363	Wash contaminated clothing before reuse.
P370	In case of fire:
P371	In case of major fire and large quantities:
P372	Explosion risk in case of fire.
P373	DO NOT fight fire when fire reaches explosives.
P374	Fight fire with normal precautions from a reasonable distance.
P376	Stop leak if safe to do so. Oxidising gases (section 2.4) 1
P377	Leaking gas fire: Do not extinguish, unless leak can be stopped safely.
P378
P380	Evacuate area.
P381	Eliminate all ignition sources if safe to do so.
P390	Absorb spillage to prevent material damage.
P391	Collect spillage. Hazardous to the aquatic environment
P301 + P310	IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P301 + P312	IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P301 + P330 + P331	IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P302 + P334	IF ON SKIN: Immerse in cool water/wrap in wet bandages.
P302 + P350	IF ON SKIN: Gently wash with plenty of soap and water.
P303 + P361 + P353	IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304 + P312	IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell.
P304 + P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P304 + P341	IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P306 + P360	IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes.
P307 + P311	IF exposed: call a POISON CENTER or doctor/physician.
P308 + P313	IF exposed or concerned: Get medical advice/attention.
P309 + P311	IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
P333 + P313	IF SKIN irritation or rash occurs: Get medical advice/attention.
P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P370 + P376	In case of fire: Stop leak if safe to Do so.
P370 + P378	In case of fire:
P370 + P380	In case of fire: Evacuate area.
P370 + P380 + P375	In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion.
P371 + P380 + P375	In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion.
Storage
Code	Phrase
P401
P402	Store in a dry place.
P403	Store in a well-ventilated place.
P404	Store in a closed container.
P405	Store locked up.
P406	Store in corrosive resistant/ container with a resistant inner liner.
P407	Maintain air gap between stacks/pallets.
P410	Protect from sunlight.
P411
P412	Do not expose to temperatures exceeding 50 oC/ 122 oF.
P413
P420	Store away from other materials.
P422
P402 + P404	Store in a dry place. Store in a closed container.
P403 + P233	Store in a well-ventilated place. Keep container tightly closed.
P403 + P235	Store in a well-ventilated place. Keep cool.
P410 + P403	Protect from sunlight. Store in a well-ventilated place.
P410 + P412	Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF.
P411 + P235	Keep cool.
Disposal
Code	Phrase
P501	Dispose of contents/container to ...
P502	Refer to manufacturer/supplier for information on recovery/recycling

Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed
H304	May be fatal if swallowed and enters airways
H305	May be harmful if swallowed and enters airways
H310	Fatal in contact with skin
H311	Toxic in contact with skin
H312	Harmful in contact with skin
H313	May be harmful in contact with skin
H314	Causes severe skin burns and eye damage
H315	Causes skin irritation
H316	Causes mild skin irritation
H317	May cause an allergic skin reaction
H318	Causes serious eye damage
H319	Causes serious eye irritation
H320	Causes eye irritation
H330	Fatal if inhaled
H331	Toxic if inhaled
H332	Harmful if inhaled
H333	May be harmful if inhaled
H334	May cause allergy or asthma symptoms or breathing difficulties if inhaled
H335	May cause respiratory irritation
H336	May cause drowsiness or dizziness
H340	May cause genetic defects
H341	Suspected of causing genetic defects
H350	May cause cancer
H351	Suspected of causing cancer
H360	May damage fertility or the unborn child
H361	Suspected of damaging fertility or the unborn child
H361d	Suspected of damaging the unborn child
H362	May cause harm to breast-fed children
H370	Causes damage to organs
H371	May cause damage to organs
H372	Causes damage to organs through prolonged or repeated exposure
H373	May cause damage to organs through prolonged or repeated exposure
Environmental hazards
Code	Phrase
H400	Very toxic to aquatic life
H401	Toxic to aquatic life
H402	Harmful to aquatic life
H410	Very toxic to aquatic life with long-lasting effects
H411	Toxic to aquatic life with long-lasting effects
H412	Harmful to aquatic life with long-lasting effects
H413	May cause long-lasting harmful effects to aquatic life
H420	Harms public health and the environment by destroying ozone in the upper atmosphere

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CAS No.: 38116-61-9

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CAS No.: 38116-61-9

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