Home Cart Sign in  
Chemical Structure| 41270-69-3 Chemical Structure| 41270-69-3

Structure of 41270-69-3

Chemical Structure| 41270-69-3

*Storage: {[sel_prStorage]}

*Shipping: {[sel_prShipping]}

,{[proInfo.pro_purity]}

4.5 *For Research Use Only !

{[proInfo.pro_purity]}
Cat. No.: {[proInfo.prAm]} Purity: {[proInfo.pro_purity]}

Change View

Size Price VIP Price

US Stock

Global Stock

In Stock
{[ item.pr_size ]} Inquiry {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate,item.pr_is_large_size_no_price, item.vip_usd) ]}

US Stock: ship in 0-1 business day
Global Stock: ship in 5-7 days

  • {[ item.pr_size ]}

In Stock

- +

Please Login or Create an Account to: See VIP prices and availability

US Stock: ship in 0-1 business day
Global Stock: ship in 2 weeks

  • 1-2 Day Shipping
  • High Quality
  • Technical Support
Product Citations

Alternative Products

Product Details of [ 41270-69-3 ]

CAS No. :41270-69-3
Formula : C10H9N3
M.W : 171.20
SMILES Code : NC1=NC(C2=CC=CC=C2)=CN=C1
MDL No. :MFCD10697807
InChI Key :PSEVKGFJGGKCIX-UHFFFAOYSA-N
Pubchem ID :12453550

Safety of [ 41270-69-3 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302
Precautionary Statements:P280-P305+P351+P338

Application In Synthesis of [ 41270-69-3 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 41270-69-3 ]

[ 41270-69-3 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 33332-28-4 ]
  • [ 98-80-6 ]
  • [ 41270-69-3 ]
YieldReaction ConditionsOperation in experiment
83% With bis-triphenylphosphine-palladium(II) chloride; sodium carbonate; In 1,4-dioxane; water; at 20 - 90℃; for 16.1667h;Inert atmosphere; To a stirred solution of 6-chloropyrazin-2-amine (50 g, 0.3861 mol) in dioxane:water (400 mL; 100 mL) was added benzeneboronic acid (56.4 g, 0.46 mol). The reaction mixture was purged with nitrogen for 20 min then charged Na2CO3 (70.6 g, 0.57 mol) and Pd(PPh3)Cl2 (13.5 g, 0.01930 mol). The reaction mixture was again purged with nitrogen. The reaction mixture was stirred at RT for 10 min followed by heating at 90° C. for 16 h. The reaction was monitored by TLC & LCMS. The reaction mixture was filter through celite and distilled. The reaction was diluted with water and extracted with ethyl acetate (3×200 mL). The combined organic layers were washed (brine), dried (anhydrous Na2SO4) & concentrated under vacuum to get the solid which was purified by column chromatography over silica gel (100-200 mesh) [Ethyl acetate: Hexane (3:7) as eluent] to get the desired product (55 g, 83percent). LCMS: 172 [M+1]+. 1H NMR (400 MHz, CHLOROFORM-d) delta 8.38 (s, 1H), 7.83-7.99 (m, 3H), 7.40-7.49 (m, 3H), 4.82 (br. s., 2H)
55% With potassium phosphate; 1,1'-bis(di-tertbutylphosphino)ferrocene; palladium diacetate; In 1,4-dioxane; at 100℃; for 5h;Inert atmosphere; Sealed tube; General procedure: To a solution of the requisite chloro-amino-substituted heteroaromatic in anhydrous 1,4-dioxane (30 volumes wrt chloride) in a sealed tube was introduced phenylboronic acid (1.5 equiv) and finely ground potassium phosphate (2.0 equiv). The solution was degassed (N2 bubbling) for 5 min, Pd(OAc)2 (5 mol percent wrt chloride) and di-tert-butylphosphinoferrocene (5 mol percent wrt chloride) introduced and degassing continued for a further 5 min. The tube was sealed under nitrogen and heated with rapid stirring at 100 °C for 5 h. After cooling, the reaction mixture was filtered in vacuo through a celite pad and the precipitated material washed with 1,4-dioxane. The combined filtrates were evaporated and purified by flash column chromatography (neat hexane to 1:1 hexane/EtOAc gradient containing 2.5percent by volume Et3N) to furnish the biarylanilines 13, 14 and 15.
 

Historical Records

Technical Information

Categories

Related Functional Groups of
[ 41270-69-3 ]

Aryls

Chemical Structure| 13535-13-2

A574867 [13535-13-2]

2-Amino-5-phenylpyrazine

Similarity: 0.98

Chemical Structure| 41270-67-1

A203276 [41270-67-1]

3-Phenylpyrazin-2-amine

Similarity: 0.92

Chemical Structure| 1126634-72-7

A940619 [1126634-72-7]

4-(6-Aminopyrazin-2-yl)benzonitrile

Similarity: 0.90

Chemical Structure| 1349717-36-7

A268368 [1349717-36-7]

(3-(6-Aminopyrazin-2-yl)phenyl)methanol

Similarity: 0.90

Chemical Structure| 1365969-34-1

A257728 [1365969-34-1]

(4-(6-Aminopyrazin-2-yl)phenyl)methanol

Similarity: 0.90

Amines

Chemical Structure| 13535-13-2

A574867 [13535-13-2]

2-Amino-5-phenylpyrazine

Similarity: 0.98

Chemical Structure| 41270-67-1

A203276 [41270-67-1]

3-Phenylpyrazin-2-amine

Similarity: 0.92

Chemical Structure| 1126634-72-7

A940619 [1126634-72-7]

4-(6-Aminopyrazin-2-yl)benzonitrile

Similarity: 0.90

Chemical Structure| 1349717-36-7

A268368 [1349717-36-7]

(3-(6-Aminopyrazin-2-yl)phenyl)methanol

Similarity: 0.90

Chemical Structure| 1365969-34-1

A257728 [1365969-34-1]

(4-(6-Aminopyrazin-2-yl)phenyl)methanol

Similarity: 0.90

Related Parent Nucleus of
[ 41270-69-3 ]

Pyrazines

Chemical Structure| 13535-13-2

A574867 [13535-13-2]

2-Amino-5-phenylpyrazine

Similarity: 0.98

Chemical Structure| 41270-67-1

A203276 [41270-67-1]

3-Phenylpyrazin-2-amine

Similarity: 0.92

Chemical Structure| 1126634-72-7

A940619 [1126634-72-7]

4-(6-Aminopyrazin-2-yl)benzonitrile

Similarity: 0.90

Chemical Structure| 1349717-36-7

A268368 [1349717-36-7]

(3-(6-Aminopyrazin-2-yl)phenyl)methanol

Similarity: 0.90

Chemical Structure| 1365969-34-1

A257728 [1365969-34-1]

(4-(6-Aminopyrazin-2-yl)phenyl)methanol

Similarity: 0.90