400-66-8|2-Bromo-4-nitro-6-(trifluoromethyl)aniline| Ambeed

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Quality Control of [ 400-66-8 ] Purity: 95% SDS Specification

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Product Details of [ 400-66-8 ]

CAS No. :	400-66-8
Formula :	C₇H₄BrF₃N₂O₂
M.W :	285.02
SMILES Code :	NC1=C(Br)C=C(C=C1C(F)(F)F)[N+]([O-])=O
MDL No. :	MFCD14560537
Boiling Point :	No data available
InChI Key :	VTSOQYVBDQONBG-UHFFFAOYSA-N
Pubchem ID :	11471654

Safety of [ 400-66-8 ]

GHS Pictogram:
Signal Word:	Warning
Hazard Statements:	H302-H315-H319-H335
Precautionary Statements:	P261-P305+P351+P338

Application In Synthesis of [ 400-66-8 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Downstream synthetic route of [ 400-66-8 ]

[ 400-66-8 ] Synthesis Path-Downstream 1~35

1
[ 121-01-7 ]
[ 400-66-8 ]

Yield	Reaction Conditions	Operation in experiment
91%	With bromine; In acetic acid; at 120℃; for 2.5h;	Bromine (0.60 mL) dissolved in acetic acid (11 mL) was added dropwise to a solution of 4-nitro-2-trifluoromethyl-phenylamine (2.4 g) in acetic acid (12 mL). The reaction mixture was heated to 120C for 2l/2 hours, poured into water (400 mL) and filtered. The collected solid was washed with water (200 mL) and dried in vacuo to furnish 3.03 g (91% yield) of the title compound as a yellow solid NMR (500 MHz, DMSO-d6): 7.08 (s, 2H), 8.23 (d, 1H), 8.51 (d, 1H).
91%	With bromine; acetic acid; at 120℃; for 2.5h;	2-Bromo-4-nitro-6-trifluoromethyl-phenylamine.; Bromine (0.60 mL) dissolved in acetic acid (11 mL) was added dropwise to a solution of 4-nitro-2-trifluoromethyl-phenylarnine (2.4 g) in acetic acid (12 mL). The reaction mixture was heated to 120 C for 21A hours, poured into water (400 mL) and filtered. The collected solid was washed with water (200 mL) and dried in vacuo to furnish 3.03 g (91% yield) of the title compound as a yellow solid. 1H NMR (500 MHz, DMSOd6): 7.08 (s, 2H), 8.23 (d, IH), 8.51 (d, IH).

References: [1]Journal of Chemical Research,2013,vol. 37,p. 197 - 200.
[2]Patent: WO2005/87754,2005,A1 .Location in patent: Page/Page column 41.
[3]Patent: WO2006/29623,2006,A1 .Location in patent: Page/Page column 58.
[4]Journal of Organic Chemistry,1983,vol. 48,p. 2321 - 2327.
[5]Industrial and Engineering Chemistry,1953,vol. 45,p. 1730,1732.
Industrial and Engineering Chemistry,1954,vol. 46,p. 2213,2218, 2219.

2
[ 2401-85-6 ]
[ 400-66-8 ]
[ 68105-56-6 ]