Home Cart Sign in  
Chemical Structure| 372519-10-3 Chemical Structure| 372519-10-3

Structure of 372519-10-3

Chemical Structure| 372519-10-3

*Storage: {[sel_prStorage]}

*Shipping: {[sel_prShipping]}

,{[proInfo.pro_purity]}

4.5 *For Research Use Only !

{[proInfo.pro_purity]}
Cat. No.: {[proInfo.prAm]} Purity: {[proInfo.pro_purity]}

Change View

Size Price VIP Price

US Stock

Global Stock

In Stock
{[ item.pr_size ]} Inquiry {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate,item.pr_is_large_size_no_price, item.vip_usd) ]}

US Stock: ship in 0-1 business day
Global Stock: ship in 5-7 days

  • {[ item.pr_size ]}

In Stock

- +

Please Login or Create an Account to: See VIP prices and availability

US Stock: ship in 0-1 business day
Global Stock: ship in 2 weeks

  • 1-2 Day Shipping
  • High Quality
  • Technical Support
Product Citations

Alternative Products

Product Details of [ 372519-10-3 ]

CAS No. :372519-10-3
Formula : C7H2BrF3O
M.W : 238.99
SMILES Code : O=CC1=C(Br)C=C(F)C(F)=C1F
MDL No. :MFCD15527216
Boiling Point : No data available
InChI Key :BXXUAIPEOHAIKN-UHFFFAOYSA-N
Pubchem ID :9834632

Safety of [ 372519-10-3 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H312-H315-H319-H332-H335
Precautionary Statements:P261-P264-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P330-P332+P313-P337+P313-P362-P403+P233-P405-P501

Application In Synthesis of [ 372519-10-3 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 372519-10-3 ]

[ 372519-10-3 ] Synthesis Path-Downstream   1~22

YieldReaction ConditionsOperation in experiment
Example 2 2-Bromo-4,5,6-trifluorobenzaldehyde can be obtained similarly to Example 1 starting from 1-bromo-3,4,5-trifluorobenzene 1H-NMR (400 MHz, CDCl3/TMS): δ=10.24 (dd, 4J(HF)=1.5 Hz, 5J(HF)=1 Hz, 1 H, CHO), 7.38 (ddd, 3J(HH)=9 Hz, 4J(HF)=6 Hz, 5J(HF)=2 Hz, 1 H, Har).-19F-NMR (376.5 MHz, 1H broad-band decoupled, CDCl3/CFCl3): δ=-123.4 (dd, 3J=20 Hz and 13 Hz), -135.9 (dd, 3J=19 Hz and 13 Hz), -158.0 (dd, 3J=20 Hz and 19 Hz).
  • 2
  • [ 372519-10-3 ]
  • [ 1031-15-8 ]
  • [ 915944-51-3 ]
  • 3
  • [ 2591-86-8 ]
  • [ 138526-69-9 ]
  • [ 372519-10-3 ]
  • 6
  • [ 372519-10-3 ]
  • [ 849052-25-1 ]
  • [ 1400812-82-9 ]
  • 7
  • [ 372519-10-3 ]
  • C16H7BrF3I [ No CAS ]
  • 8
  • [ 372519-10-3 ]
  • C16H6BrCl2F3 [ No CAS ]
  • 9
  • [ 372519-10-3 ]
  • C16H6BrClF3I [ No CAS ]
  • 10
  • [ 372519-10-3 ]
  • [ 536-74-3 ]
  • C15H7F3O [ No CAS ]
  • 11
  • [ 372519-10-3 ]
  • [ 90-04-0 ]
  • 1,2,3-trifluoro-5-methoxyacridine [ No CAS ]
  • 12
  • [ 372519-10-3 ]
  • [ 90-04-0 ]
  • C14H10F3NO2 [ No CAS ]
YieldReaction ConditionsOperation in experiment
With 1,1'-bis-(diphenylphosphino)ferrocene; tris-(dibenzylideneacetone)dipalladium(0); sodium t-butanolate; In water; toluene; at 60℃; for 2h;Inert atmosphere; General procedure: α-bromoaldehyde 4a-g (1 mmol), 2-methoxyaniline (5) (1 mmol), Pd2(dba)3 (0.02 mmol), dppf (0.04 mmol) and t-BuONa (1.5 mmol) were added to a mixture of Kolliphor EL (1.8 mL, 1.97% H2O) and toluene (0.2 mL) and stirred (500 rpm) at 60 C for 2 h. After cooling to r.t. ,EtOH was added (about 10 mL, until the reaction mixture became homogeneous) and the solvents were removed under reduced pressure.
  • 13
  • [ 372519-10-3 ]
  • 4-Bromo-6,7-difluoro-1H-indazole [ No CAS ]
YieldReaction ConditionsOperation in experiment
96% With hydrazine hydrate; In 1,4-dioxane; at 80℃; for 24h;Inert atmosphere; A flask equipped with a magnetic stir bar and reflux condenser was charged with 6-bromo- 2,3,4-trifluoro-benzaldehyde (1.00 g, 4.18 mmol) and 1,4-dioxane (10 mL), followed by hydrazine hydrate (0.61 mL, 12.6 mmol). The mixture was heated at 80C under a nitrogen atmosphere for 24 hours. The mixture was cooled to room temperature and evaporated under reduced pressure. The residue was dissolved in EtOAc (50 mL) and washed with water (3 x 15 mL). The combined organic phase was dried over Na2SO4, filtered and evaporated to give 4-bromo-6,7-difluoro-1H-indazole as a yellow solid, which was used in the next step without further purification (0.94 g, 96 % yield, m/z: 233 [M+H]+ observed).1H NMR (400 MHz, CDCl3) d 10.76 (s, 1H), 8.10 (d, J = 3.2 Hz, 1H), 7.23 (dd, J = 9.9, 5.8 Hz, 1H).
  • 14
  • [ 372519-10-3 ]
  • 4-Bromo-6,7-difluoro-1-(3-methoxypropyl)indazole [ No CAS ]
  • 4-bromo-6,7-difluoro-2-(3-methoxypropyl)indazole [ No CAS ]
  • 15
  • [ 372519-10-3 ]
  • 4-(2-(2-chloropyrimidin-5-yl)cyclopropyl)-6,7-difluoro-1-(3-methoxypropyl)-1H-indazole [ No CAS ]
  • 16
  • [ 372519-10-3 ]
  • trans-4-(2-([2,2'-bipyrimidin]-5-yl)cyclopropyl)-6,7-difluoro-1-(3-methoxypropyl)-1H-indazole [ No CAS ]
  • 17
  • [ 372519-10-3 ]
  • trans-6,7-difluoro-1-(3-methoxypropyl)-4-[2-(2-pyrimidin-2-ylpyrimidin-5-yl)cyclopropyl]indazole [ No CAS ]
  • trans-4-(2-([2,2'-bipyrimidin]-5-yl)cyclopropyl)-6,7-difluoro-1-(3-methoxypropyl)-1H-indazole [ No CAS ]
  • 18
  • [ 372519-10-3 ]
  • 6-bromo-2,3,4-trifluoro-benzoic acid [ No CAS ]
YieldReaction ConditionsOperation in experiment
With sodium hypochlorite; sodium dihydrogenphosphate; 2-methyl-but-2-ene; In tetrahydrofuran; tert-butyl alcohol; at 20℃; for 0.5h; A mixture of 6-bromo-2, 3, 4-trifluorobenzaldehyde (750 mg, 3.14 mmol), 2-methyl-2-butene (2.6 mL, 31.38 mmol), NaClO 2 (1.4 g, 15.61 mmol) and NaH 2PO 4 (1.3 mL, 15.69 mmol) in t-BuOH (20 mL) and THF (10 mL) was stirred at room temperature for 30 minutes. The mixture was adjusted to pH ~ 3 with 1 N HCl aq. and extracted with EtOAc (30 mL x 3). The combined organic layers were washed with brine (30 mL), dried over Na 2SO 4 and concentrated under reduced pressure to give 6-bromo-2, 3, 4-trifluorobenzoic acid (1 g, crude) as a white solid. LC-MS: 255, 257 (M+H) +.
  • 19
  • [ 372519-10-3 ]
  • 6-bromo-2,3,4-trifluoro-N,N-dimethylbenzamide [ No CAS ]
  • 20
  • [ 372519-10-3 ]
  • 6-cyano-2,3,4-trifluoro-N,N-dimethylbenzamide [ No CAS ]
  • 21
  • [ 372519-10-3 ]
  • methyl ((1S,2R)-2-((S)-1-(1-(2-(4-cyano-3-(dimethylcarbamoyl)-2,6-difluorophenyl)-2-azaspiro[3.3]heptan-6-yl)piperidin-4-yl)-1-(3-fluorophenyl)-2-(2-methyl-1H-imidazol-1-yl)ethyl)cyclopentyl)carbamate [ No CAS ]
  • 22
  • [ 33513-42-7 ]
  • [ 138526-69-9 ]
  • [ 372519-10-3 ]
YieldReaction ConditionsOperation in experiment
62% To a stirred mixture of 5-bromo-1, 2, 3-trifluorobenzene (2 g, 9.48 mmol) in THF (20 mL) was added LDA (2 M in THF, 5.7 mL, 11.37 mmol) at -65C for 30 minutes. Then DMF (1.1 mL, 14.22 mmol) was added to above solution. The reaction mixture was stirred at this temperature for 3 hours. Then the mixture was quenched with sat. NH 4Cl aq. (20 mL) and extracted with EtOAc (20 mL x 3). The combined organic layers were washed with brine (20 mL), dried over Na 2SO 4 and concentrated under reduced pressure. The residue was purified by flash column chromatography on silica gel to give 6-bromo-2, 3, 4-trifluorobenzaldehyde (1.4 g, yield 62%) as a yellow solid. LC-MS: 239, 241 (M+H) +.
 

Historical Records

Technical Information

• Alkyl Halide Occurrence • Arndt-Eistert Homologation • Baeyer-Villiger Oxidation • Barbier Coupling Reaction • Baylis-Hillman Reaction • Benzylic Oxidation • Birch Reduction • Blanc Chloromethylation • Bucherer-Bergs Reaction • Clemmensen Reduction • Complex Metal Hydride Reductions • Corey-Bakshi-Shibata (CBS) Reduction • Corey-Chaykovsky Reaction • Corey-Fuchs Reaction • Fischer Indole Synthesis • Friedel-Crafts Reaction • General Reactivity • Grignard Reaction • Hantzsch Dihydropyridine Synthesis • Henry Nitroaldol Reaction • Hiyama Cross-Coupling Reaction • Horner-Wadsworth-Emmons Reaction • Hunsdiecker-Borodin Reaction • Hydride Reductions • Hydrogenolysis of Benzyl Ether • Julia-Kocienski Olefination • Kinetics of Alkyl Halides • Knoevenagel Condensation • Kumada Cross-Coupling Reaction • Lawesson's Reagent • Leuckart-Wallach Reaction • McMurry Coupling • Meerwein-Ponndorf-Verley Reduction • Mukaiyama Aldol Reaction • Nozaki-Hiyama-Kishi Reaction • Passerini Reaction • Paternò-Büchi Reaction • Petasis Reaction • Peterson Olefination • Pictet-Spengler Tetrahydroisoquinoline Synthesis • Preparation of Aldehydes and Ketones • Preparation of Alkylbenzene • Preparation of Amines • Preparation of Carboxylic Acids • Prins Reaction • Reactions of Aldehydes and Ketones • Reactions of Alkyl Halides with Reducing Metals • Reactions of Amines • Reactions of Benzene and Substituted Benzenes • Reactions of Carboxylic Acids • Reactions of Dihalides • Reformatsky Reaction • Robinson Annulation • Schlosser Modification of the Wittig Reaction • Schmidt Reaction • Specialized Acylation Reagents-Ketenes • Stetter Reaction • Stille Coupling • Stobbe Condensation • Substitution and Elimination Reactions of Alkyl Halides • Suzuki Coupling • Tebbe Olefination • Ugi Reaction • Vilsmeier-Haack Reaction • Wittig Reaction • Wolff-Kishner Reduction

Categories

Related Functional Groups of
[ 372519-10-3 ]

Fluorinated Building Blocks

Chemical Structure| 360576-04-1

A196752 [360576-04-1]

6-Bromo-2,3-difluorobenzaldehyde

Similarity: 0.98

Chemical Structure| 154650-59-6

A501099 [154650-59-6]

2-Bromo-4,6-difluorobenzaldehyde

Similarity: 0.93

Chemical Structure| 1263377-81-6

A135545 [1263377-81-6]

2,3-Dibromo-5,6-difluorobenzaldehyde

Similarity: 0.91

Chemical Structure| 1370025-54-9

A568089 [1370025-54-9]

2-Bromo-6-fluoro-4-methylbenzaldehyde

Similarity: 0.91

Chemical Structure| 360575-28-6

A201006 [360575-28-6]

2-Bromo-6-fluorobenzaldehyde

Similarity: 0.91

Aryls

Chemical Structure| 360576-04-1

A196752 [360576-04-1]

6-Bromo-2,3-difluorobenzaldehyde

Similarity: 0.98

Chemical Structure| 154650-59-6

A501099 [154650-59-6]

2-Bromo-4,6-difluorobenzaldehyde

Similarity: 0.93

Chemical Structure| 1263377-81-6

A135545 [1263377-81-6]

2,3-Dibromo-5,6-difluorobenzaldehyde

Similarity: 0.91

Chemical Structure| 1370025-54-9

A568089 [1370025-54-9]

2-Bromo-6-fluoro-4-methylbenzaldehyde

Similarity: 0.91

Chemical Structure| 360575-28-6

A201006 [360575-28-6]

2-Bromo-6-fluorobenzaldehyde

Similarity: 0.91

Bromides

Chemical Structure| 360576-04-1

A196752 [360576-04-1]

6-Bromo-2,3-difluorobenzaldehyde

Similarity: 0.98

Chemical Structure| 154650-59-6

A501099 [154650-59-6]

2-Bromo-4,6-difluorobenzaldehyde

Similarity: 0.93

Chemical Structure| 1263377-81-6

A135545 [1263377-81-6]

2,3-Dibromo-5,6-difluorobenzaldehyde

Similarity: 0.91

Chemical Structure| 1370025-54-9

A568089 [1370025-54-9]

2-Bromo-6-fluoro-4-methylbenzaldehyde

Similarity: 0.91

Chemical Structure| 360575-28-6

A201006 [360575-28-6]

2-Bromo-6-fluorobenzaldehyde

Similarity: 0.91

Aldehydes

Chemical Structure| 360576-04-1

A196752 [360576-04-1]

6-Bromo-2,3-difluorobenzaldehyde

Similarity: 0.98

Chemical Structure| 154650-59-6

A501099 [154650-59-6]

2-Bromo-4,6-difluorobenzaldehyde

Similarity: 0.93

Chemical Structure| 1263377-81-6

A135545 [1263377-81-6]

2,3-Dibromo-5,6-difluorobenzaldehyde

Similarity: 0.91

Chemical Structure| 1370025-54-9

A568089 [1370025-54-9]

2-Bromo-6-fluoro-4-methylbenzaldehyde

Similarity: 0.91

Chemical Structure| 360575-28-6

A201006 [360575-28-6]

2-Bromo-6-fluorobenzaldehyde

Similarity: 0.91