Structure of 652-34-6
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The BI-3802 was designed by Boehringer Ingelheim and could be obtained free of charge through the Boehringer Ingelheim open innovation portal opnMe.com, associated with its negative control.
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CAS No. : | 652-34-6 |
Formula : | C7H2F4O3 |
M.W : | 210.08 |
SMILES Code : | O=C(O)C1=C(F)C(F)=C(O)C(F)=C1F |
MDL No. : | MFCD00129952 |
InChI Key : | FTLHGQOBAPTEHE-UHFFFAOYSA-N |
Pubchem ID : | 98835 |
GHS Pictogram: |
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Signal Word: | Warning |
Hazard Statements: | H315-H319-H335 |
Precautionary Statements: | P261-P305+P351+P338 |
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
51.2 g of polystyrene-aminomethyl resin (loading 1.36 mmol/g, 69.6 mmol; from Argonaut Technologies, USA) are suspended in 700 ml of DMF. 41.6 g (107.8 mmol) of HOBt and 24.1 g (114.8 mmol) of 4-hydroxy-2,3,5,6-tetrafluoro-benzoic acid are added. After 15 min, 16.9 ml (107.8 mmol) of N,N'-diisopropylcarbodiimide are added to the reaction mixture while stirring gently, and it is then stirred overnight. It is filtered, and the remaining resin is washed with DMF. The resulting resin is resuspended in 450 ml of DMF, mixed with 8.26 ml (83.5 mmol) of piperidine and shaken. After 2 h, filtration is repeated and the remaining resin is added to a solution of 120 ml of 1 M hydrochloric acid in 500 ml of DMF and shaken for a further 2 h. Renewed filtration is followed by washing with 500 ml each of DMF, THF and DCM. Drying in vacuo at 50 C. results in 77.2 g of the polymer-bound title compound. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
90% | With sulfuric acid; for 16h;Reflux; | To a solution of <strong>[652-34-6]2,3,5,6-tetrafluoro-4-hydroxybenzoic acid</strong> hydrate (5.2 g, 22.8 mmol) in methanol (400 ml) concentrated sulphuric acid (98%, 2 ml)was added. The solutionwas heated to reflux for 16 h. TLC was used to monitor the reaction. After the complete conversion, methanol was removed, and then water (100 ml) was added to the residual. Dichloromethane was used to extract the product from aqueous solution. The extract was dried over anhydrous magnesium sulphate, and the solvent was removed under reduced pressure to give white solid methyl 2,3,5,6-tetrafluoro-4-hydroxybenzoate (5.01 g, yield 90%). 1H NMR, CD3OD: 4.92(br s,1H, OH), 3.92 (s, 3H, COOCH3). 13C NMR, CD3OD: 162.7 (s, COO),148.70e138.12 (m, Ar CF), 53.16 (s, CH3). 19F NMR, CD3OD: -144.12 (m, 2F), -165.99 (m, 2F) To a solution of methyl 2,3,5,6-tetrafluoro-4-hydroxybenzoate (1.02 g, 4.55 mmol) in anhydrous THF (10 ml) was added a solution of thallium ethoxide (1.19 g, 4.78 mmol, 1.05 eq) in anhydrous THF (5 ml). The white solid was formed and the suspension was stirred for further 3 h. The white solid was collected, washed with anhydrous THF, dried under reduced pressure, to give product Tl-6 (1.82 g, yield 90%). 1H NMR, CD3OD: 3.92 (s, 3H, COOCH3). 13C NMR, CD3OD: 162.7 (s, COO), 148.70e138.12 (m, Ar CF), 53.16 (s, CH3). 19F NMR, CD3OD: -144.12 (m, 2F), -165.99 (m, 2F). |
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