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Chemical Structure| 652-34-6 Chemical Structure| 652-34-6

Structure of 652-34-6

Chemical Structure| 652-34-6

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Product Details of [ 652-34-6 ]

CAS No. :652-34-6
Formula : C7H2F4O3
M.W : 210.08
SMILES Code : O=C(O)C1=C(F)C(F)=C(O)C(F)=C1F
MDL No. :MFCD00129952
InChI Key :FTLHGQOBAPTEHE-UHFFFAOYSA-N
Pubchem ID :98835

Safety of [ 652-34-6 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Application In Synthesis of [ 652-34-6 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 652-34-6 ]

[ 652-34-6 ] Synthesis Path-Downstream   1~35

  • 2
  • [ 2002-99-5 ]
  • [ 652-34-6 ]
  • 3
  • [ 602-94-8 ]
  • [ 652-18-6 ]
  • [ 652-34-6 ]
  • 6
  • [ 64-17-5 ]
  • [ 652-34-6 ]
  • [ 123270-98-4 ]
  • 7
  • [ 115-20-8 ]
  • [ 652-34-6 ]
  • [ 562070-99-9 ]
  • 8
  • [ 652-34-6 ]
  • aminomethylated polystyrene [ No CAS ]
  • (polystyrene resin)-NH-C(O)-p-C6F6-OH [ No CAS ]
  • 9
  • 2-[(2-pyridin-2-ylquinoline-4-carbonyl)amino]ethylammonium chloride [ No CAS ]
  • [ 652-34-6 ]
  • 2-pyridin-2-yl-quinoline-4-carboxylic acid [2-(2,3,5,6-tetrafluoro-4-hydroxy-benzoylamino)-ethyl]-amide [ No CAS ]
  • 11
  • [ 652-34-6 ]
  • [ 562071-00-5 ]
  • 12
  • [ 652-34-6 ]
  • [ 562071-03-8 ]
  • 13
  • [ 652-34-6 ]
  • [ 562071-02-7 ]
  • 14
  • [ 652-34-6 ]
  • [ 562071-01-6 ]
  • 15
  • [ 652-34-6 ]
  • C27H5F13O8 [ No CAS ]
  • 16
  • [ 652-34-6 ]
  • C41H17F13O8 [ No CAS ]
  • 17
  • [ 652-34-6 ]
  • C41H13F13O10 [ No CAS ]
  • 21
  • [ 652-34-6 ]
  • Ethyl 2,3,5,6-tetrafluoro-4-[(E,E)-3,7,11-trimethyldodeca-2,6,10-trien-1-yloxy]benzoate [ No CAS ]
  • 22
  • [ 652-34-6 ]
  • Benzyl 2,4,6-tris(benzyloxy)-3,5-difluorobenzoate [ No CAS ]
  • 23
  • [ 652-34-6 ]
  • Sodium 2,3,5,6-tetrafluoro-4-[(E,E)-3,7,11-trimethyldodeca-2,6,10-trien-1-yloxy]benzoate [ No CAS ]
  • 24
  • [ 434-64-0 ]
  • [ 652-34-6 ]
  • 25
  • [ 652-34-6 ]
  • C8H3F5NOPol [ No CAS ]
YieldReaction ConditionsOperation in experiment
51.2 g of polystyrene-aminomethyl resin (loading 1.36 mmol/g, 69.6 mmol; from Argonaut Technologies, USA) are suspended in 700 ml of DMF. 41.6 g (107.8 mmol) of HOBt and 24.1 g (114.8 mmol) of 4-hydroxy-2,3,5,6-tetrafluoro-benzoic acid are added. After 15 min, 16.9 ml (107.8 mmol) of N,N'-diisopropylcarbodiimide are added to the reaction mixture while stirring gently, and it is then stirred overnight. It is filtered, and the remaining resin is washed with DMF. The resulting resin is resuspended in 450 ml of DMF, mixed with 8.26 ml (83.5 mmol) of piperidine and shaken. After 2 h, filtration is repeated and the remaining resin is added to a solution of 120 ml of 1 M hydrochloric acid in 500 ml of DMF and shaken for a further 2 h. Renewed filtration is followed by washing with 500 ml each of DMF, THF and DCM. Drying in vacuo at 50 C. results in 77.2 g of the polymer-bound title compound.
  • 27
  • [ 553-26-4 ]
  • [ 5970-45-6 ]
  • [ 652-34-6 ]
  • [Zn2(4,4'-bipyridine)(2,3,5,6-tetrafluoro-4-hydroxybenzoate)2]*(4,4'-bipyridine) [ No CAS ]
  • 28
  • [ 553-26-4 ]
  • cobalt(II) chloride hexahydrate [ No CAS ]
  • [ 652-34-6 ]
  • [Co2(4,4'-bipyridine)(2,3,5,6-tetrafluoro-4-hydroxybenzoate)2]*(4,4'-bipyridine) [ No CAS ]
  • 29
  • [ 475289-85-1 ]
  • [ 652-34-6 ]
  • [ 1257325-77-1 ]
  • 30
  • [ 67-56-1 ]
  • [ 652-34-6 ]
  • [ 58286-07-0 ]
YieldReaction ConditionsOperation in experiment
90% With sulfuric acid; for 16h;Reflux; To a solution of <strong>[652-34-6]2,3,5,6-tetrafluoro-4-hydroxybenzoic acid</strong> hydrate (5.2 g, 22.8 mmol) in methanol (400 ml) concentrated sulphuric acid (98%, 2 ml)was added. The solutionwas heated to reflux for 16 h. TLC was used to monitor the reaction. After the complete conversion, methanol was removed, and then water (100 ml) was added to the residual. Dichloromethane was used to extract the product from aqueous solution. The extract was dried over anhydrous magnesium sulphate, and the solvent was removed under reduced pressure to give white solid methyl 2,3,5,6-tetrafluoro-4-hydroxybenzoate (5.01 g, yield 90%). 1H NMR, CD3OD: 4.92(br s,1H, OH), 3.92 (s, 3H, COOCH3). 13C NMR, CD3OD: 162.7 (s, COO),148.70e138.12 (m, Ar CF), 53.16 (s, CH3). 19F NMR, CD3OD: -144.12 (m, 2F), -165.99 (m, 2F) To a solution of methyl 2,3,5,6-tetrafluoro-4-hydroxybenzoate (1.02 g, 4.55 mmol) in anhydrous THF (10 ml) was added a solution of thallium ethoxide (1.19 g, 4.78 mmol, 1.05 eq) in anhydrous THF (5 ml). The white solid was formed and the suspension was stirred for further 3 h. The white solid was collected, washed with anhydrous THF, dried under reduced pressure, to give product Tl-6 (1.82 g, yield 90%). 1H NMR, CD3OD: 3.92 (s, 3H, COOCH3). 13C NMR, CD3OD: 162.7 (s, COO), 148.70e138.12 (m, Ar CF), 53.16 (s, CH3). 19F NMR, CD3OD: -144.12 (m, 2F), -165.99 (m, 2F).
 

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Technical Information

• Acidity of Phenols • Alkyl Halide Occurrence • Arndt-Eistert Homologation • Baeyer-Villiger Oxidation • Barbier Coupling Reaction • Baylis-Hillman Reaction • Bucherer-Bergs Reaction • Chan-Lam Coupling Reaction • Clemmensen Reduction • Corey-Bakshi-Shibata (CBS) Reduction • Corey-Chaykovsky Reaction • Electrophilic Substitution of the Phenol Aromatic Ring • Etherification Reaction of Phenolic Hydroxyl Group • Fischer Indole Synthesis • Grignard Reaction • Halogenation of Phenols • Henry Nitroaldol Reaction • Horner-Wadsworth-Emmons Reaction • Hunsdiecker-Borodin Reaction • Hydride Reductions • Lawesson's Reagent • Leuckart-Wallach Reaction • McMurry Coupling • Meerwein-Ponndorf-Verley Reduction • Oxidation of Phenols • Passerini Reaction • Paternò-Büchi Reaction • Pechmann Coumarin Synthesis • Petasis Reaction • Peterson Olefination • Pictet-Spengler Tetrahydroisoquinoline Synthesis • Preparation of Aldehydes and Ketones • Preparation of Amines • Preparation of Carboxylic Acids • Prins Reaction • Reactions of Aldehydes and Ketones • Reactions of Amines • Reactions of Benzene and Substituted Benzenes • Reactions of Carboxylic Acids • Reformatsky Reaction • Reimer-Tiemann Reaction • Robinson Annulation • Schlosser Modification of the Wittig Reaction • Schmidt Reaction • Specialized Acylation Reagents-Ketenes • Stobbe Condensation • Tebbe Olefination • Ugi Reaction • Wittig Reaction • Wolff-Kishner Reduction

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