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Chemical Structure| 59084-16-1 Chemical Structure| 59084-16-1

Structure of 59084-16-1

Chemical Structure| 59084-16-1

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Product Details of [ 59084-16-1 ]

CAS No. :59084-16-1
Formula : C8H12ClNO2
M.W : 189.64
SMILES Code : O=C(Cl)C1CCN(C(C)=O)CC1
MDL No. :MFCD02094017
InChI Key :OHCPVLJEAHBMEG-UHFFFAOYSA-N
Pubchem ID :100950

Safety of [ 59084-16-1 ]

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H314
Precautionary Statements:P264-P271-P301+P330+P331-P305+P351+P338-P363-P403+P233-P501
Class:8
UN#:3261
Packing Group:

Application In Synthesis of [ 59084-16-1 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 59084-16-1 ]

[ 59084-16-1 ] Synthesis Path-Downstream   1~3

  • 1
  • [ 59084-16-1 ]
  • [ 193217-39-9 ]
  • 2
  • [ 1068-55-9 ]
  • [ 59084-16-1 ]
  • [ 101335-11-9 ]
  • [ 946598-81-8 ]
YieldReaction ConditionsOperation in experiment
33% Step 1 1-[4-(2-Chloro-4-fluoro-benzoyl)-piperidin-1-yl]-ethanone <strong>[101335-11-9]2-Chloro-4-fluoro-1-iodobenzol</strong> (5 g, 19 mmol) was solved in THF (3 mL) and at -10 C. isopropyl magnesium chloride-lithium chloride (2M in THF) was added dropwise and the mixture stirred for 30 minutes at 0 C. At -10 C. 1-acetyl-isonipecotoyl chloride was added (3.3 g, 18 mmol) solved in THF (2 mL) and the mixture stirred for 10 minutes to -10 C. and 4 h to 0 C. Water was added and the reaction extracted with dichloromethane. Chromatography with Heptane/EtOAc (2:1) gave the desired compound as a clear orange liquid (1.8 g, 33% yield). (m/e): 284.3 (M+H+).
 

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Technical Information

• Acyl Group Substitution • Alkyl Halide Occurrence • Baeyer-Villiger Oxidation • Barbier Coupling Reaction • Baylis-Hillman Reaction • Bucherer-Bergs Reaction • Catalytic Hydrogenation • Chan-Lam Coupling Reaction • Clemmensen Reduction • Complex Metal Hydride Reductions • Corey-Bakshi-Shibata (CBS) Reduction • Corey-Chaykovsky Reaction • Fischer Indole Synthesis • General Reactivity • Grignard Reaction • Henry Nitroaldol Reaction • Hiyama Cross-Coupling Reaction • Horner-Wadsworth-Emmons Reaction • Hydride Reductions • Kinetics of Alkyl Halides • Kumada Cross-Coupling Reaction • Lawesson's Reagent • Leuckart-Wallach Reaction • McMurry Coupling • Meerwein-Ponndorf-Verley Reduction • Passerini Reaction • Paternò-Büchi Reaction • Petasis Reaction • Peterson Olefination • Pictet-Spengler Tetrahydroisoquinoline Synthesis • Preparation of Aldehydes and Ketones • Preparation of Amines • Prins Reaction • Reactions of Aldehydes and Ketones • Reactions of Alkyl Halides with Reducing Metals • Reactions of Amines • Reformatsky Reaction • Robinson Annulation • Rosenmund Reduction • Schlosser Modification of the Wittig Reaction • Schmidt Reaction • Specialized Acylation Reagents-Carbodiimides and Related Reagents • Specialized Acylation Reagents-Ketenes • Stille Coupling • Stobbe Condensation • Substitution and Elimination Reactions of Alkyl Halides • Suzuki Coupling • Tebbe Olefination • Ugi Reaction • Wittig Reaction • Wolff-Kishner Reduction

Categories

Related Functional Groups of
[ 59084-16-1 ]

Chlorides

Chemical Structure| 865074-93-7

A193707 [865074-93-7]

1-(4-(Chloromethyl)piperidin-1-yl)ethanone

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8-(4-Chlorobutyl)-8-azaspiro[4.5]decane-7,9-dione

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Amides

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A678851 [1181455-29-7]

1-Isopropyl-5-oxopyrrolidine-3-carbonyl chloride

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A279363 [1181577-49-0]

1-Cyclohexyl-5-oxopyrrolidine-3-carbonyl chloride

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1-(3-(Chloromethyl)piperidin-1-yl)ethanone

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Acyl Chlorides

Chemical Structure| 1181455-29-7

A678851 [1181455-29-7]

1-Isopropyl-5-oxopyrrolidine-3-carbonyl chloride

Similarity: 0.83

Chemical Structure| 1181577-49-0

A279363 [1181577-49-0]

1-Cyclohexyl-5-oxopyrrolidine-3-carbonyl chloride

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Related Parent Nucleus of
[ 59084-16-1 ]

Piperidines

Chemical Structure| 865074-93-7

A193707 [865074-93-7]

1-(4-(Chloromethyl)piperidin-1-yl)ethanone

Similarity: 0.85

Chemical Structure| 21098-11-3

A477962 [21098-11-3]

8-(4-Chlorobutyl)-8-azaspiro[4.5]decane-7,9-dione

Similarity: 0.81

Chemical Structure| 1082844-32-3

A997150 [1082844-32-3]

1-(3-(Chloromethyl)piperidin-1-yl)ethanone

Similarity: 0.81