Home Life Science Inhibitors/Agonists Stapled Peptide
Stapling plays a crucial role in stabilizing peptides within an α-helical conformation. The resulting stapled peptides can effectively compete for binding to protein targets engaged in protein-protein interactions facilitated by α-helices. Over the past few years, specific design principles have surfaced to enhance their binding affinity and biological activity. This trend is accompanied by a growing reliance on computational approaches in the design of stapled peptides.
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