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The SMO-SHH signaling pathway is a crucial component of diverse neurological processes, encompassing neuronal cell differentiation, proliferation, and survival. Dysregulation of SMO-SHH signaling results in numerous physiological changes that contribute to neurological disorders like ASD and play a role in cognitive decline. The abnormal downregulation of SMO-SHH signals leads to the proteolytic cleavage of GLI (glioma-associated homolog) into GLI3 (repressor), thereby enhancing oxidative stress, neuronal excitotoxicity, neuroinflammation, and apoptosis by suppressing the expression of target genes.
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