Home Cart Sign in  
Chemical Structure| 956697-53-3 Chemical Structure| 956697-53-3

Structure of Sonidegib
CAS No.: 956697-53-3

Chemical Structure| 956697-53-3

*Storage: {[sel_prStorage]}

*Shipping: {[sel_prShipping]}

,{[proInfo.pro_purity]}

LDE225 is an antagonist of Smoothened that can inhibit hedgehog signaling with IC50 of 2.5 nM.

Synonyms: Erismodegib; LDE225; NVP-LDE225

4.5 *For Research Use Only !

{[proInfo.pro_purity]}
Cat. No.: {[proInfo.prAm]} Purity: {[proInfo.pro_purity]}

Change View

Size Price VIP Price

US Stock

Global Stock

In Stock
{[ item.pr_size ]} Inquiry {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate,item.pr_is_large_size_no_price, item.vip_usd) ]}

US Stock: ship in 0-1 business day
Global Stock: ship in 5-7 days

  • {[ item.pr_size ]}

In Stock

- +

Please Login or Create an Account to: See VIP prices and availability

US Stock: ship in 0-1 business day
Global Stock: ship in 2 weeks

  • 1-2 Day Shipping
  • High Quality
  • Technical Support
Product Citations

Alternative Products

Product Details of Sonidegib

CAS No. :956697-53-3
Formula : C26H26F3N3O3
M.W : 485.50
SMILES Code : O=C(C1=C(C)C(C2=CC=C(OC(F)(F)F)C=C2)=CC=C1)NC3=CC=C(N4C[C@@H](C)O[C@@H](C)C4)N=C3
Synonyms :
Erismodegib; LDE225; NVP-LDE225
MDL No. :MFCD16038928
InChI Key :VZZJRYRQSPEMTK-CALCHBBNSA-N
Pubchem ID :24775005

Safety of Sonidegib

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Related Pathways of Sonidegib

Hedgehog

Isoform Comparison

Biological Activity

Clinical Trial:

NCT Number Conditions Phases Recruitment Completion Date Locations
NCT01208831 Advanced Solid Tumor Cancers|M... More >>edulloblastoma|Basal Cell Carcinoma Less << PHASE1 COMPLETED 2025-10-13 Novartis Investigative Site, H... More >>ong Kong, Hong Kong|Novartis Investigative Site, Nagoya-city, Aichi, 466-8560, Japan|Novartis Investigative Site, Kobe-city, Hyogo, 650-0017, Japan|Novartis Investigative Site, Taipei, 10048, Taiwan Less <<
NCT01529450 Basal Cell Carcinoma COMPLETED 2025-08-13 Stanford University, School of... More >> Medicine, Stanford, California, 94305, United States Less <<
NCT01125800 Medulloblastoma|Rhabdomyosarco... More >>ma|Neuroblastoma|Hepatoblastoma|Glioma|Astrocytoma Less << PHASE1|PHASE2 COMPLETED 2025-10-14 Children's Healthcare of Atlan... More >>ta Childern Hosp - ATL, Atlanta, Georgia, 30342, United States|Sidney Kimmel Comprehensive Cancer Center/Johns Hopkins Med. John Hopkins, Baltimore, Maryland, 21231, United States|Dana Farber Cancer Institute DFCI (3), Boston, Massachusetts, 02115, United States|Seattle Children's Hospital CPKC412A2114, Seattle, Washington, 98105, United States|Novartis Investigative Site, Parkville, Victoria, 3052, Australia|Novartis Investigative Site, Toronto, Ontario, M5G 1X8, Canada|Novartis Investigative Site, Toronto, Ontario, M5G 2M9, Canada|Novartis Investigative Site, Paris, 75231, France|Novartis Investigative Site, Villejuif Cedex, 94805, France|Novartis Investigative Site, Bologna, BO, 40139, Italy|Novartis Investigative Site, Milano, MI, 20133, Italy|Novartis Investigative Site, Roma, RM, 00168, Italy|Novartis Investigative Site, Sutton, Surrey, SM2 5PT, United Kingdom|Novartis Investigative Site, Newcastle Upon Tyne, NE1 4LP, United Kingdom Less <<
NCT01826214 Acute Leukemias PHASE2 COMPLETED 2025-05-15 Duke University Medical Center... More >> SC-5, Durham, North Carolina, 27710, United States|Novartis Investigative Site, Adelaide, South Australia, 5000, Australia|Novartis Investigative Site, Prahran, Victoria, 3181, Australia|Novartis Investigative Site, Salzburg, 5020, Austria|Novartis Investigative Site, Wien, 1090, Austria|Novartis Investigative Site, Leuven, 3000, Belgium|Novartis Investigative Site, Yvoir, 5530, Belgium|Novartis Investigative Site, Montreal, Quebec, H1T 2M4, Canada|Novartis Investigative Site, Montreal, Quebec, H3T 1E2, Canada|Novartis Investigative Site, Dresden, 01307, Germany|Novartis Investigative Site, Frankfurt, 60590, Germany|Novartis Investigative Site, Magdeburg, 39120, Germany|Novartis Investigative Site, Ulm, 89081, Germany|Novartis Investigative Site, Debrecen, 4032, Hungary|Novartis Investigative Site, Amsterdam, 1081 HV, Netherlands|Novartis Investigative Site, Nijmegen, 6525 GA, Netherlands|Novartis Investigative Site, Rotterdam, 3015 CE, Netherlands|Novartis Investigative Site, Rotterdam, 3075 EA, Netherlands|Novartis Investigative Site, Bergen, NO-5021, Norway|Novartis Investigative Site, Trondheim, 7006, Norway|Novartis Investigative Site, Salamanca, Castilla y Leon, 37007, Spain|Novartis Investigative Site, Valencia, Comunidad Valenciana, 46026, Spain|Novartis Investigative Site, London, WC1E 6HX, United Kingdom Less <<
NCT01327053 Basal Cell Carcinoma PHASE2 COMPLETED 2018-06-29 Highlands Oncology Group, Faye... More >>tteville, Arkansas, 72703, United States|University of California at Los Angeles UCLA 3, Los Angeles, California, 90095, United States|Stanford University Medical Center Stanford Univ 2, Stanford, California, 94304, United States|University of Colorado School of Medicine UC, Aurora, Colorado, 80045, United States|Washington Hospital Center Wash Hospital, Washington, District of Columbia, 20010, United States|H Lee Moffitt Cancer Center and Research Institute Cutaneous Onc Dept, Tampa, Florida, 33612, United States|NorthwesternUniv.Med.School/Robert H. Lurie Comp.Cancer Ctr Study coordinator, Chicago, Illinois, 60611, United States|Dana Farber Cancer Institute DFCI - MA, Boston, Massachusetts, 02215, United States|Henry Ford Hospital Henry Ford, Detroit, Michigan, 48202 2689, United States|Washington University School Of Medicine-Siteman Cancer Ctr Siteman, Saint Louis, Missouri, 63110, United States|Comprehensive Cancer Centers of Nevada CCC of Nevada- Southwest (2), Las Vegas, Nevada, 89109, United States|Hackensack University Medical Center Hackensack (SC), Hackensack, New Jersey, 07601, United States|New York University Medical Center SC-2, New York, New York, 10016, United States|Penn State University / Milton S. Hershey Medical Center Hershey Medical, Hershey, Pennsylvania, 17033-085, United States|University of Pittsburgh Medical Center UPMC, Pittsburgh, Pennsylvania, 15213, United States|Baylor Health Care System/Sammons Cancer Center Baylor Texas Oncology, Dallas, Texas, 75246, United States|Texas Oncology Tex Onc 3, Dallas, Texas, 75246, United States|Texas Oncology Texas Onc - Amarillo, Dallas, Texas, 75246, United States|University of Texas MD Anderson Cancer Center MD Anderson, Houston, Texas, 77030, United States|Texas Oncology Cancer Care & Research Center, Waco, Texas, 76712, United States|Texoma Cancer Center Texoma Cancer Center, Wichita Falls, Texas, 76310, United States|University of Utah / Huntsman Cancer Institute Huntsman/Univ UT, Salt Lake City, Utah, 84103, United States|Novartis Investigative Site, St Leonards, New South Wales, 2065, Australia|Novartis Investigative Site, Geelong, Victoria, 3220, Australia|Novartis Investigative Site, Bruxelles, 1200, Belgium|Novartis Investigative Site, Wilrijk, 2610, Belgium|Novartis Investigative Site, Waterloo, Ontario, N2J 1C4, Canada|Novartis Investigative Site, Sainte-Foy, Quebec, G1V 4T3, Canada|Novartis Investigative Site, Lyon Cedex, 69373, France|Novartis Investigative Site, Marseille Cedex 05, 13885, France|Novartis Investigative Site, Pierre Benite Cedex, 69495, France|Novartis Investigative Site, Toulouse Cedex 9, 31059, France|Novartis Investigative Site, Villejuif Cedex, 94805, France|Novartis Investigative Site, Berlin, 13353, Germany|Novartis Investigative Site, Essen, 45147, Germany|Novartis Investigative Site, Freiburg, 79106, Germany|Novartis Investigative Site, Gera, 07548, Germany|Novartis Investigative Site, Hannover, 30625, Germany|Novartis Investigative Site, Kiel, 24105, Germany|Novartis Investigative Site, Mainz, 55131, Germany|Novartis Investigative Site, Muenchen, 81377, Germany|Novartis Investigative Site, Muenster, 48157, Germany|Novartis Investigative Site, Stade, 21682, Germany|Novartis Investigative Site, Athens, 161 21, Greece|Novartis Investigative Site, Budapest, H-1085, Hungary|Novartis Investigative Site, Debrecen, 4032, Hungary|Novartis Investigative Site, Szeged, H-6725, Hungary|Novartis Investigative Site, Torino, TO, 10126, Italy|Novartis Investigative Site, Napoli, 80131, Italy|Novartis Investigative Site, Barcelona, Catalunya, 08035, Spain|Novartis Investigative Site, Madrid, 28034, Spain|Novartis Investigative Site, Madrid, 28046, Spain|Novartis Investigative Site, Bern, 3010, Switzerland|Novartis Investigative Site, Geneve, 1211, Switzerland|Novartis Investigative Site, Zürich, 8091, Switzerland|Novartis Investigative Site, High Heaton, Newcastle Upon Tyne, NE7 7DN, United Kingdom|Novartis Investigative Site, Yeovil, Somerset, BA21 4AT, United Kingdom|Novartis Investigative Site, Cardiff, CF14 4XW, United Kingdom|Novartis Investigative Site, Glasgow, G3 8SJ, United Kingdom|Novartis Investigative Site, Leicester, LE1 5WW, United Kingdom|Novartis Investigative Site, London, EC1A 7BE, United Kingdom|Novartis Investigative Site, Manchester, M13 9WL, United Kingdom Less <<
NCT02151864 Hepatocellular Carcinoma|Cirrh... More >>osis Less << PHASE1 COMPLETED 2025-09-17 UCSD Moores Cancer Center, La ... More >>Jolla, California, 92093, United States Less <<
NCT02002689 PTCH1 or SMO Activated Solid a... More >>nd Hematologic Tumors Less << PHASE2 TERMINATED 2025-03-15 University of California Davis... More >> Cancer Center UC Davis Cancer (3), Sacramento, California, 95817, United States|Rocky Mountain Cancer Centers RMCC - Aurora, Greenwood Village, Colorado, United States|Lurie Children's Hospital of Chicago Developmental Therapeutics, Chicago, Illinois, 60611, United States|Minnesota Oncology Hematology, P.A. Southdate Medical Center, Minneapolis, Minnesota, 55404, United States|Cleveland Clinic Foundation Cleveland Clinic (19), Cleveland, Ohio, 44195, United States|Sanford Research Sanford Health, Sioux Falls, South Dakota, 57104, United States|Oncology Consultants Oncology Group, Houston, Texas, 77024, United States|MD Anderson Cancer Center/University of Texas MD Anderson Cancer Center (3), Houston, Texas, 77030, United States|Intermountain Medical Center Intermountain Healthcare, Murray, Utah, 84157, United States|Seattle Cancer Care Alliance Skagit Valley Hospital, Seattle, Washington, 98109-1023, United States Less <<
NCT00880308 Advanced Solid Tumor Cancers|M... More >>edulloblastoma|Basal Cell Carcinoma Less << PHASE1 COMPLETED 2025-07-13 University of Pittsburgh Medic... More >>al Center SC, Pittsburgh, Pennsylvania, 15213, United States|Cancer Therapy & Research Center / UT Health Science Center InstituteForDrugDevelopment(5), San Antonio, Texas, 78229, United States|Novartis Investigative Site, Barcelona, Catalunya, 08035, Spain|Novartis Investigative Site, Zürich, 8091, Switzerland|Novartis Investigative Site, Leicester, LE1 5WW, United Kingdom Less <<
NCT01911416 Pancreatic Ductal Adenocarcino... More >>ma Less << WITHDRAWN 2025-10-14 Huntsman Cancer Institute, Sal... More >>t Lake City, Utah, United States Less <<
NCT02086513 Graft Versus Host Disease PHASE1 TERMINATED 2025-12-16 Beth Israel Deaconess Medical ... More >>Center, Boston, Massachusetts, 02215, United States|Dana Farber Cancer Institute, Boston, Massachusetts, 02215, United States|Massachusetts General Hospital, Boston, Massachusetts, 02215, United States Less <<
NCT02195973 Recurrent Ovarian Cancer PHASE1 COMPLETED 2017-09-30 University of Alabama at Birmi... More >>ngham, Birmingham, Alabama, 35294, United States Less <<
NCT02111187 Prostate Cancer PHASE1 COMPLETED 2017-01-18 Johns Hopkins Hospital, Baltim... More >>ore, Maryland, 21205, United States Less <<
NCT01764776 Normal Hepatic Function|Impair... More >>ed Hepatic Function Less << PHASE1 COMPLETED 2025-03-15 University of Miami Div. of Cl... More >>inical Pharmacology, Miami, Florida, 33136, United States|Novartis Investigative Site, Bruxelles, 1200, Belgium|Novartis Investigative Site, Sofia, 1612, Bulgaria|Novartis Investigative Site, Berlin, 14050, Germany|Novartis Investigative Site, Tel-Aviv, 64239, Israel Less <<

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.06mL

0.41mL

0.21mL

10.30mL

2.06mL

1.03mL

20.60mL

4.12mL

2.06mL

References

 

Historical Records

Categories