Home PROTAC Molecule RAR/PROTAC
The retinoic acid (RA) signal can be transmitted either through RXR (retinoid-X receptor)-non-permissive RA receptor/RXR heterodimers or RXR-permissive RXR heterodimers. The role of RA signaling in malignant brain tumors like glioblastoma multiforme (GBM) and gliosarcoma (GS) is not well understood. Specifically, the influence of RA on the proliferation, survival, differentiation, or metabolism of cells derived from GBM or GS with features of stem cells (SLGCs) remains unclear.
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