Products Cited in Publications Worldwide Cu (II)-Organic Coordination Polymer Networks for Persistent Nitric Oxide Release in Tumor Therapy

Cu (II)-Organic Coordination Polymer Networks for Persistent Nitric Oxide Release in Tumor Therapy

Jeong, Hyejoong; Kim, Na Kyung; Park, Daehwan; Youn, Heesoo; Osuji, Chinedum O; Doh, Junsang

DOI: PMID:

Abstract

Nitric oxide (NO) plays a key role in regulating the immunesystem by polarizing macrophages toward the proinflammatory M1phenotype, which is beneficial for cancer immunotherapy. We developeda Cu-organic coordination polymer network to sustainably release NO fromendogenous donors. This robust polymer network was constructed througha dual-interaction process: complexation and cross-linking. The carboxylategroups of deprotonated (BA)served as bidentate ligands for the formation of Cu(II) complexes. Theacrylate moiety of BA anchored these complexes in the polymer network,forming a cross-linked film. Cu ions within the network catalyticallypromoted NO release from , maintaining this releaseeven after 90 days in a physiological environment. The released NOeffectively polarized both resting (M0) and tumor-promoting (M2)macrophages to the M1 phenotype. With their demonstrated physiological stability and sustained NO release performance, BA-Cu films hold potential as anticancer patches capable of continuously promoting antitumoral macrophages.

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A11075983883-26-597%

4-((6-(Acryloyloxy)hexyl)oxy)benzoic acid

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