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Type HazMat fee for 500 gram (Estimated)
Excepted Quantity USD 0.00
Limited Quantity USD 15-60
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Accessible (Haz class 3, 4, 5 or 8), International USD 200+
Chemical Structure| 612-28-2 Chemical Structure| 612-28-2
Chemical Structure| 612-28-2

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Product Details of Telmisartan Impurity 2

CAS No. :612-28-2
Formula : C7H8N2O2
M.W : 152.15
SMILES Code : CNC1=C(C=CC=C1)[N+]([O-])=O
MDL No. :MFCD00007090
InChI Key :KFBOUJZFFJDYTA-UHFFFAOYSA-N
Pubchem ID :69157

Safety of Telmisartan Impurity 2

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H301+H311+H331-H373
Precautionary Statements:P280-P301+P310
Class:6.1
UN#:2811
Packing Group:

Application In Synthesis of Telmisartan Impurity 2

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 612-28-2 ]

[ 612-28-2 ] Synthesis Path-Downstream   1~6

  • 1
  • [ 612-28-2 ]
  • [ 100-46-9 ]
  • [ 2622-63-1 ]
  • [ 716-79-0 ]
  • 2
  • [ 612-28-2 ]
  • [ 100-46-9 ]
  • [ 2622-63-1 ]
  • 3
  • [ 612-28-2 ]
  • [ 100-51-6 ]
  • [ 2622-63-1 ]
YieldReaction ConditionsOperation in experiment
90% With sodium sulfide hydrate; iron(III) chloride hexahydrate; at 150℃; for 24h;Inert atmosphere; General procedure: A 20-mL test-tube equipped with a magnetic stirring bar was charged with o-nitroaniline 1 (2.5 mmol, 1 equiv), alcohol 2 or 5 (3 mmol, 1.2equiv), Na2S·nH2O (?60percent, 130 mg, 1 mmol, 40 molpercent) and FeCl3·6H2O(7 mg, 0.025 mmol, 1 molpercent). The resulting mixture was stirred for 24h under an argon atmosphere at the indicated temperature (see Schemes 2 and 3 and Table 2). After cooling to r.t., the mixture was purified in different ways. (i) For NH benzimidazole products, the mixture was washed with CH2Cl2 (3 × 2 mL) then dissolved in MeOH.The MeOH solution was filtered through a short pad of silica gel. The filtrate was concentrated in vacuo to afford the NH benzimidazole product. Further purification by column or recrystallization was carried out if necessary. (ii) For N-methyl-2-phenylbenzimidazole 3ha and quinoxalines 5, the crude mixture was dissolved in a minimum volume of CH2Cl2 and purified by column chromatography (silica gel or alumina, heptane?EtOAc, EtOAc, EtOAc?MeOH, hexane?Et2O). We noted that some 13C NMR signals of NH-benzimidazoles are missing or difficult to observe.
  • 4
  • [ 612-28-2 ]
  • [ 2835-06-5 ]
  • [ 2622-63-1 ]
YieldReaction ConditionsOperation in experiment
79% With potassium carbonate; In toluene; at 140℃; for 24h;Schlenk technique; Sealed tube; In a clean dry 10 ml Schlenk reaction tube, sequentially adding a 2-nitro-N-methylaniline 38 mg, benzene glycine 113 mg, potassium carbonate 80 mg, in order to 1 ml of toluene as a solvent, the reaction tube seal, in 140 °C reaction under 24 hours. After the reaction, the reaction mixture directly by rotating the evaporimeter turns on lathe does, then the volume ratio of 8:1 of petroleum ether and ethyl acetate as the eluant, by separating by silica gel column, to obtain 39 mg light yellow solid, yield 79percent.
  • 5
  • [ 612-28-2 ]
  • [ 2622-63-1 ]
  • 6
  • [ 612-28-2 ]
  • [ 100-52-7 ]
  • [ 2622-63-1 ]
 

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