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The BI-3802 was designed by Boehringer Ingelheim and could be obtained free of charge through the Boehringer Ingelheim open innovation portal opnMe.com, associated with its negative control.
Sulfadiazine Sodium is one of the short-acting sulfonamides used in combination with pyrimethamine to treat toxoplasmosis in patients with acquired immunodeficiency syndrome and in newborns with congenital infections.
Synonyms: Sulfadiazin-natrium; Sulfadiazine sodium; Sulfadiazine(sodium)
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Batch number can be found on the product's label following the word 'Batch'.
Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.
Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.
Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.
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CAS No. : | 547-32-0 |
Formula : | C10H9N4NaO2S |
M.W : | 272.26 |
SMILES Code : | O=S(C1=CC=C(N)C=C1)([N-]C2=NC=CC=N2)=O.[Na+] |
Synonyms : |
Sulfadiazin-natrium; Sulfadiazine sodium; Sulfadiazine(sodium)
|
MDL No. : | MFCD00067333 |
InChI Key : | JLDCNMJPBBKAHH-UHFFFAOYSA-N |
Pubchem ID : | 15899898 |
GHS Pictogram: |
![]() ![]() |
Signal Word: | Danger |
Hazard Statements: | H318-H411 |
Precautionary Statements: | P280-P305+P351+P338+P310 |
Class: | 9 |
UN#: | 3077 |
Packing Group: | Ⅲ |
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
85% | General procedure: A solution containing 1 mmol of the respective metal salt was added to sodium sulfadiazine (1mmol, 0.272 g) in 25 mL of distilled water. The mixture was refluxed for 1 h followed by the addition of N-methyl-N-phenyldithiocarbamate (1 mmol, 0.205 g) or N-ethyl-N-phenyldithiocarbamate (1 mmol, 0.219 g) in 25 mL of distilled water. The reaction mixture was further refluxed for 3 h, cool to room temperature and filtered. The product was dried over CaCl2. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
97% | General procedure: A solution containing 1 mmol of the respective metal salt was added to sodium sulfadiazine (1mmol, 0.272 g) in 25 mL of distilled water. The mixture was refluxed for 1 h followed by the addition of N-methyl-N-phenyldithiocarbamate (1 mmol, 0.205 g) or N-ethyl-N-phenyldithiocarbamate (1 mmol, 0.219 g) in 25 mL of distilled water. The reaction mixture was further refluxed for 3 h, cool to room temperature and filtered. The product was dried over CaCl2. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
84% | General procedure: A solution containing 1 mmol of the respective metal salt was added to sodium sulfadiazine (1mmol, 0.272 g) in 25 mL of distilled water. The mixture was refluxed for 1 h followed by the addition of N-methyl-N-phenyldithiocarbamate (1 mmol, 0.205 g) or N-ethyl-N-phenyldithiocarbamate (1 mmol, 0.219 g) in 25 mL of distilled water. The reaction mixture was further refluxed for 3 h, cool to room temperature and filtered. The product was dried over CaCl2. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
92% | General procedure: A solution containing 1 mmol of the respective metal salt was added to sodium sulfadiazine (1mmol, 0.272 g) in 25 mL of distilled water. The mixture was refluxed for 1 h followed by the addition of N-methyl-N-phenyldithiocarbamate (1 mmol, 0.205 g) or N-ethyl-N-phenyldithiocarbamate (1 mmol, 0.219 g) in 25 mL of distilled water. The reaction mixture was further refluxed for 3 h, cool to room temperature and filtered. The product was dried over CaCl2. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
1 g | Triphenylphosphine 2.6g Benzyl bromide and 1.7g30ml Toluene was dissolved in the reaction proceeding for 3 hours at 110 dried filtered and the resulting precipitate naeeotda obtained a solid 3.0g.Methylene chloride50ml the solid-worked indirect 3.0g Sodium Sulfadiazine 1.2g dissolved after 24 hours of reaction at room temperature and the precipitate was then filtered worked indirect figured after the liquid was evaporated under reduced pressure (evaporating) through the process gained a solid 1.0g, NMR data as to the Formula 10It was identified as the compound. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
1 g | Triphenylphosphine and 2.6g to 2.2g 4-Nitrobenzyl bromide was dissolved in 30ml Toluene proceed the reaction for 3 hours at 110 dried filtered and the resulting precipitate naeeotda obtained a solid 3.0g.After the solid-worked indirect 3.0g dissolved in Methylenechloride 50ml Sodium Sulfadiazine 1.2g and a rear-worked indirect liquid precipitation was filtered out after 24 hours reaction at 25 Through vacuum distillation (evaporating) process got a solid 1.0g,NMR data was confirmed as to the compound of formula 9. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With pyridine; In tetrahydrofuran; at 20℃; for 14h;Cooling with ice; | In an oil bath at 80 C, a solution of gallic acid and 3 times (m: V) acetic acid anhydride was stirred for 12 hours mixing, adding 15 times volume of distilled water was allowed to stand 48 hours, insoluble matter was collected by filtration, and dried in vacuo to afford 3,4,5-triacetyl gallate; 3,4,5-triacetyl gallic acid was refluxed with thionyl chloride for 6 hours at 70 C in oil bath and thionyl chloride was recovered under reduced pressure to give 3,4,5-triacetyl gallate chloride; The mixture of 3,4,5-triacetylgallinoyl chloride and sodium sulfadiazine in tetrahydrofuran was added with a small amount of pyridine as catalyst. The mixture was stirred in an ice bath for 2 hours and stirred at room temperature for 12 hours. After the partial tetrahydrofuran was evaporated under reduced pressure at 80 C for 48 hours, The insoluble material was collected by filtration, dried in vacuo. The product was recrystallized from methanol-tetrahydrofuran. To obtain 3,4,5-triacetyl gallic acid sulfadiazine. | |
3.05 g | With pyridine; In tetrahydrofuran; for 2h;Cooling with ice; | HAMDC was synthesized from GA and sulfadiazine sodium following the synthetic route whichwas reported previously [27]. Five grams of GA was dissolved in 20 mL acetyl oxide and refluxed for8 h. Subsequently, 300 mL distilled water was added to produce recipitates. The precipitates werefiltrated and dried, then 20 mL SOCl2 was added and refluxed for 6 h. The solution was evaporated invacuo and mixed with 8 g sulfadiazine sodium in THF and stirred in an ice bath for 2 h. Upon theend of the reactions, an appropriate volume of distilled water (~10 times to the volume of reactionsystem) was added to the mixture. The obtained product was precipitated and filtered. It was thenrecrystallized in a THF-methanol solvent system and dried in a vacuum oven at 80 C. The obtainedproduct exhibited a pale yellow color in a powder form. The yield of HAMDC was 61% (3.05 g). |