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Chemical Structure| 480438-74-2 Chemical Structure| 480438-74-2

Structure of 480438-74-2

Chemical Structure| 480438-74-2

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Product Details of [ 480438-74-2 ]

CAS No. :480438-74-2
Formula : C17H25BO5
M.W : 320.19
SMILES Code : O=C(OC(C)(C)C)OC1=CC=CC(B2OC(C)(C)C(C)(C)O2)=C1
MDL No. :MFCD03427273

Safety of [ 480438-74-2 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P280-P301+P312-P302+P352-P305+P351+P338

Application In Synthesis of [ 480438-74-2 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 480438-74-2 ]

[ 480438-74-2 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 890315-72-7 ]
  • [ 480438-74-2 ]
  • [ 910240-98-1 ]
YieldReaction ConditionsOperation in experiment
With sodium hydrogencarbonate;tetrakis(triphenylphosphine) palladium(0); In ethanol; water; toluene; for 6.0h;Heating / reflux; To toluene 24mL solution of <strong>[890315-72-7]tert-butyl 4-bromo-2-nitrobenzoate</strong> 3.0g were added ethanol 9.0mL, water 4.5mL, tert-butyl 3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl carbonate 3.8g, sodium hydrogen carbonate 2.1g and tetrakis (triphenylphosphine)palladium(0) 0.57g sequentially, and it was heated and refluxed under nitrogen atmosphere for 6 hours. After the reaction mixture was cooled to room temperature, ethyl acetate and water were added to it. After insoluble matter was filtrated, the organic layer was separated and collected, dried over anhydrous magnesium sulfate after washing with saturated sodium chloride aqueous solution, and the solvent was removed under reduced pressure. The obtained residue was refined by silica gel column chromatography [Fuji SILYSIA Chemical Ltd., PSQ100B(spherical type), eluent; hexane:ethyl acetate=3:1] to give tert-butyl 4-(3-(tert-butoxycarbonyl)oxyphenyl)-2-nitrobenzoate 3.6g of yellow oil. 1H-NMR(DMSO-d6) delta value: 1.51(9H,s),1.52(9H,s),7.2.9-7.34(1H,m),7.55-7.60(1H,m),7.70-7.76(2H,m),7.91(1H,d,J=8.0Hz),8.14(1H,dd,J=8.0,1.7Hz),8 .32(1H,d,J=1.7Hz).
  • 2
  • [ 890315-72-7 ]
  • [ 480438-74-2 ]
  • [ 910241-02-0 ]
 

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