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Chemical Structure| 1150632-94-2 Chemical Structure| 1150632-94-2

Structure of 1150632-94-2

Chemical Structure| 1150632-94-2

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Product Details of [ 1150632-94-2 ]

CAS No. :1150632-94-2
Formula : C8H10BrNO2
M.W : 232.07
SMILES Code : COC(C1=NC=C(Br)C=C1)OC
MDL No. :MFCD20486718

Safety of [ 1150632-94-2 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H315-H319-H335
Precautionary Statements:P261-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P362-P403+P233-P501

Application In Synthesis of [ 1150632-94-2 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1150632-94-2 ]

[ 1150632-94-2 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 1150632-94-2 ]
  • [ 73183-34-3 ]
  • [ 1150632-93-1 ]
YieldReaction ConditionsOperation in experiment
83.12% With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate; In 1,4-dioxane;Inert atmosphere; Pd(dppf)Cl2 (630.73mg, 862.00mmol) was added to a solution of Example 24B (2g, 8.62mmol), bispinacolatoboronate(2.85g, 11.21mmol), potassium acetate (2.54g, 25.86mmol) in dioxane (10mL) under nitrogen atmosphere,followed by reacting at 110C for 2 hours. When LC-MS showed the completion of the reaction, the reaction solutionwas cooled to room temperature, filtered, concentrated in vacuo and the residue was purified by flash silica gel columnchromatography to give the title compound as a black oil (2g, yield 83.12%). 1H NMR (400MHz, CHLOROFORM-d) ppm8.94 (s, 1H), 8.11 (dd, J=1.4, 7.7 Hz, 1H), 7.54 (d, J=7.8 Hz, 1H), 5.40 (s, 1H), 3.39 (s, 6H), 1.35 (s, 12H).
  • 2
  • [ 1150632-93-1 ]
  • [ 1150632-94-2 ]
  • [ 1615250-90-2 ]
 

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