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Chemical Structure| 159989-64-7 Chemical Structure| 159989-64-7

Structure of Nelfinavir
CAS No.: 159989-64-7

Chemical Structure| 159989-64-7

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Nelfinavir is a selective and potent HIV-1 protease inhibitor used in combination with other antiviral drugs in the treatment of HIV.

Synonyms: AG1341

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Nour M. Alkashef ; Mohamed N. Seleem ;

Abstract: Cryptococcosis is a fungal infection that is becoming increasingly prevalent worldwide, particularly among individuals with compromised immune systems, such as HIV patients. Amphotericin B (AmB) is the first-line treatment mainly combined with flucytosine. The scarcity and the prohibitive cost of this regimen urge the use of fluconazole as an alternative, leading to increased rates of treatment failure and relapses. Therefore, there is a critical need for efficient and cost-effective therapy to enhance the efficacy of AmB. In this study, we evaluated the efficacy of the HIV protease inhibitors (PIs) to synergize the activity of AmB in the treatment of cryptococcosis. Five PIs (ritonavir, atazanavir, saquinavir, lopinavir, and nelfinavir) were found to synergistically potentiate the killing activity of AmB against Cryptococcus strains with ƩFICI ranging between 0.09 and 0.5 against 20 clinical isolates. This synergistic activity was further confirmed in a time-kill assay, where different AmB/PIs combinations exhibited fungicidal activity within 24 hrs. Additionally, PIs in combination with AmB exhibited an extended post-antifungal effect on treated cryptococcal cells for approximately 10 hrs compared to 4 hours with AmB alone. This promising activity against cryptococcal cells did not exhibit increased cytotoxicity towards treated kidney cells, ruling out the risk of drug combination-induced nephrotoxicity. Finally, we evaluated the efficacy of AmB/PIs combinations in the Caenorhabditis elegans model of cryptococcosis, where these combinations significantly reduced the fungal burden of the treated nematodes by approximately 2.44 Log10 CFU (92.4%) compared to the untreated worms and 1.40 Log10 ((39.4%) compared to AmB alone. The cost-effectiveness and accessibility of PIs in resource-limited geographical areas compared to other antifungal agents, such as flucytosine, make them an appealing choice for combination therapy.

Xin Wang ;  Qian Yang ;  Xueyan Zhou ;  C. Dirk Keene ;  Alexey G. Ryazanov ;  Tao Ma

Abstract: INTRODUCTION: Cognitive impairment is a core feature of Down syndrome (DS), and the underlying neurobiological mechanisms remain unclear. Translation dysregulation is linked to multiple neurological disorders characterized by cognitive impairments. Phosphorylation of the translational factor eukaryotic elongation factor 2 (eEF2) by its kinase eEF2K results in inhibition of general protein synthesis. METHODS: We used genetic and pharmacological methods to suppress eEF2K in two lines of DS mouse models. We further applied multiple approaches to evaluate the effects of eEF2K inhibition on DS pathophysiology. RESULTS: We found that eEF2K signaling was overactive in the brain of patients with DS and DS mouse models. Inhibition of eEF2 phosphorylation through suppression of eEF2K in DS model mice improved multiple aspects of DS-associated pathophysiology including de novo protein synthesis deficiency, synaptic morphological defects, long-term synaptic plasticity failure, and cognitive impairments. DISCUSSION: Our data suggested that eEF2K signaling dysregulation mediates DSassociated synaptic and cognitive impairments.

Keywords: cognition ; Down syndrome ; eukaryotic elongation factor 2 kinase ; mouse model ; protein synthesis ; synaptic plasticity

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Product Details of Nelfinavir

CAS No. :159989-64-7
Formula : C32H45N3O4S
M.W : 567.78
SMILES Code : O=C([C@H]1N(C[C@@H](O)[C@@H](NC(C2=CC=CC(O)=C2C)=O)CSC3=CC=CC=C3)C[C@@]4([H])CCCC[C@@]4([H])C1)NC(C)(C)C
Synonyms :
AG1341
MDL No. :MFCD01938163
InChI Key :QAGYKUNXZHXKMR-HKWSIXNMSA-N
Pubchem ID :64143

Safety of Nelfinavir

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302
Precautionary Statements:P280-P305+P351+P338

Isoform Comparison

Biological Activity

Clinical Trial:

NCT Number Conditions Phases Recruitment Completion Date Locations
NCT00624195 HIV Infections Phase 2 Phase 3 Completed - United States, California ... More >> HIV Neurobehavioral Research Center, University of California San Diego San Diego, California, United States, 92103 University of California, San Francisco San Francisco, California, United States, 94110 United States, Maryland Johns Hopkins University- School of Medicine Baltimore, Maryland, United States, 21287 United States, Missouri Washington University St. Louis, Missouri, United States, 63110 United States, New York Mount Sinai Medical Center New York, New York, United States, 10024 Less <<
NCT00002411 HIV Infections Not Applicable Completed - -
NCT00624195 - Completed - -
NCT00002240 HIV Infections Phase 2 Completed - United States, Alabama ... More >> Clinsites / Sorra Research Ctr Birmingham, Alabama, United States, 35203 Univ of Alabama at Birmingham Birmingham, Alabama, United States, 35294 United States, California UCSD Treatment Ctr San Diego, California, United States, 92103 UCSF - San Francisco Gen Hosp San Francisco, California, United States, 94110 United States, Colorado Univ of Colorado / Health Science Ctr Denver, Colorado, United States, 80262 United States, District of Columbia ViRx / Dupont Circle Physicians Group Washington, District of Columbia, United States, 20009 United States, Georgia AIDS Research Consortium of Atlanta Atlanta, Georgia, United States, 30308 United States, Illinois Rush Presbyterian - Saint Luke's Med Ctr Chicago, Illinois, United States, 60612 United States, Missouri Washington Univ School of Medicine St Louis, Missouri, United States, 63108 United States, New York Albany Med College Albany, New York, United States, 12208 Beth Israel Med Ctr New York, New York, United States, 10003 Columbia Presbyterian Med Ctr New York, New York, United States, 10032 United States, Ohio Case Western Reserve Univ Cleveland, Ohio, United States, 44106 United States, Texas Oak Lawn Physicians Group Dallas, Texas, United States, 75219 Univ of Texas Southwestern Med Ctr of Dallas Dallas, Texas, United States, 75235 Univ TX Galveston Med Branch Galveston, Texas, United States, 77555 Canada, Ontario Ottawa General Hospital Ottawa, Ontario, Canada Less <<
NCT00006443 HIV Infections Not Applicable Completed - United States, Alabama ... More >> Michael S. Saag Birmingham, Alabama, United States, 35294 Less <<
NCT00002372 HIV Infections Phase 1 Completed - United States, California ... More >> Univ of California / San Diego Treatment Ctr San Diego, California, United States, 92103 ViRx Inc San Francisco, California, United States, 94109 United States, North Carolina Univ of North Carolina at Chapel Hill / Duke Univ Med Ctr Durham, North Carolina, United States, 27710 Less <<
NCT00005106 HIV Infections Phase 4 Completed - -
NCT00002216 HIV Infections Not Applicable Completed - United States, Pennsylvania ... More >> Anderson Clinical Research Pittsburgh, Pennsylvania, United States, 15213 Less <<
NCT00002224 HIV Infections Phase 3 Completed - -
NCT00346580 Sepsis PHASE1 COMPLETED 2025-09-05 Mayo Clinic, Rochester, Minnes... More >>ota, 55905, United States Less <<
NCT00005002 HIV Infections Phase 3 Unknown - United States, California ... More >> Agouron Pharmaceuticals Inc San Diego, California, United States, 92121 Less <<
NCT00122590 HIV Infections Not Applicable Terminated - France ... More >> Service de Medecine Interne Hopital Cochin Paris, France, 75014 Less <<
NCT00099359 Disease Transmission, Vertical... More >> Vertical Human Immunodeficiency Virus Transmission HIV Infections Less << Phase 3 Completed - United States, California ... More >> Miller Children's Hospital Long Beach, California, United States, 90806 United States, Florida University of FL Gainesville, Florida, United States, 32610-0296 University of FL-HSC Jacksonville, Florida, United States, 32209 United States, New Jersey University Medical and Dental School of NJ-Newark Campus Newark, New Jersey, United States, 07103 United States, Texas Texas Childrens Hospital Houston, Texas, United States, 77030 Argentina Hospital I. G. A. Dr. Diego Paroissien Buenos Aires, Argentina Brazil Federal University of Minas Gerais (UFMG) Belo Horizonte, MG, Brazil, 30130-100 Universidade de Sao Paulo (USP) , MD São Paulo, Ribeirão Preto, Brazil, 14024-250 Hospital Fêmina S.A. Unidade Perinatal de Transmissão Vertical Porto Alegre, Rio Grande do Sul, Brazil, 90430001 Hospital Santa Casa (HSC) Porto Alegre, Rio Grande do Sul, Brazil, 90850 530 Hospital Nossa Senhora da Conceicao (GHC) Porto Alegre, Rio Grande do Sul, Brazil, 91350-200 Hospital dos Servidores do Estado (HSE) Rio de Janeiro, Brazil, 20221-903 Hospital Geral de Novo Iguacu Rio de Janeiro, Brazil, 26030-380 5088 - Universidade Federal de Sao Paulo (UFSP) São Paulo, Brazil, 04939-002 Puerto Rico San Juan Hospital San Juan, Puerto Rico, 00936-8344 South Africa Tygerberg Hospital Cape Town, South Africa Chris Hani Baragwanath Hospital Johannesburg, South Africa Less <<
NCT00006441 HIV Infections Not Applicable Completed - United States, Alabama ... More >> University of Alabama- Birmingham Birmingham, Alabama, United States, 35294 United States, California Rick Hecht San Francisco, California, United States, 941102859 Less <<
NCT00099359 - Completed - -
NCT00044837 HIV Infections Phase 1 Terminated - United States, Maryland ... More >> Barbara Brizz Rockville, Maryland, United States, 20852 Less <<
NCT00002423 HIV Infections Phase 2 Completed - United States, California ... More >> Saint Francis Mem Hosp San Francisco, California, United States, 94109 United States, District of Columbia Georgetown Univ Med Ctr Washington, District of Columbia, United States, 20007 United States, Florida IDC Research Initiative Altamonte Springs, Florida, United States, 32701 United States, Maryland Natl Institute of Allergy and Infectious Diseases Bethesda, Maryland, United States, 20892 United States, Missouri Kansas City AIDS Research Consortium Kansas City, Missouri, United States, 64111 United States, New York Bentley-Salick Med Practice New York, New York, United States, 10011 United States, Oklahoma Associates in Med and Mental Health Tulsa, Oklahoma, United States, 74114 United States, Oregon Portland Veterans Adm Med Ctr / Rsch & Education Grp Portland, Oregon, United States, 972109951 Less <<
NCT00002442 HIV Infections Phase 2 Completed - United States, California ... More >> AIDS Healthcare Foundation Los Angeles, California, United States, 90027 Palo Alto Veterans Affairs Health Care System Palo Alto, California, United States, 94304 United States, District of Columbia Dupont Circle Physicians Group Washington, District of Columbia, United States, 200091104 United States, Florida IDC Research Initiative Altamonte Springs, Florida, United States, 32701 North Broward Hosp District Fort Lauderdale, Florida, United States, 33316 Steinhart Medical Associates Miami, Florida, United States, 33133 United States, Illinois Northwestern Univ Med School Chicago, Illinois, United States, 60611 United States, New York Saint Vincents Hosp New York, New York, United States, 10011 St Lukes - Roosevelt Hosp Ctr New York, New York, United States, 10019 United States, Pennsylvania MCP Hahnemann Univ Hosp Philadelphia, Pennsylvania, United States, 19102 United States, Texas Southwest Infectious Disease Association / PA Dallas, Texas, United States, 75225 Univ TX Galveston Med Branch Galveston, Texas, United States, 77550 Less <<
NCT00002378 HIV Infections Phase 3 Completed - -
NCT00001133 HIV Infections Phase 1 Completed - United States, Alabama ... More >> Alabama Therapeutics CRS Birmingham, Alabama, United States, 35294 United States, California USC CRS Los Angeles, California, United States, 900331079 Ucsf Aids Crs San Francisco, California, United States, 94110 United States, Maryland Johns Hopkins Adult AIDS CRS Baltimore, Maryland, United States, 21287 United States, New York NY Univ. HIV/AIDS CRS New York, New York, United States, 10016 United States, Ohio Univ. of Cincinnati CRS Cincinnati, Ohio, United States, 452670405 United States, Pennsylvania Pitt CRS Pittsburgh, Pennsylvania, United States, 15213 Less <<
NCT00004583 HIV Infections Phase 3 Completed - -
NCT00002397 HIV Infections ... More >> AIDS-Associated Nephropathy Less << Phase 3 Completed - United States, New York ... More >> Mount Sinai Med Ctr New York, New York, United States, 10029 Less <<
NCT00000892 HIV Infections Not Applicable Completed - -
NCT00002211 HIV Infections Not Applicable Completed - United States, New Jersey ... More >> Pharmacia & Upjohn Peapack, New Jersey, United States, 07977 Less <<
NCT00002430 HIV Infections Not Applicable Completed - -
NCT00051844 Human Immunodeficiency Virus Phase 2 Completed - -
NCT00002176 HIV Infections Not Applicable Completed - United States, California ... More >> Univ of California at San Francisco Gen Hosp San Francisco, California, United States, 94110 Less <<
NCT00002220 HIV Infections Phase 3 Completed - United States, California ... More >> LAC / USC Med Ctr / Infectious Diseases Los Angeles, California, United States, 90033 United States, Connecticut Yale Univ / AIDS Clinical Trials Unit New Haven, Connecticut, United States, 06510 United States, Delaware Med Ctr of Delaware Wilmington, Delaware, United States, 19899 United States, Hawaii Hawaii AIDS Clinical Trial Unit Honolulu, Hawaii, United States, 96816 United States, Illinois Rush Presbyterian Saint Lukes Med Ctr Chicago, Illinois, United States, 606123832 United States, Maryland Johns Hopkins Hosp Baltimore, Maryland, United States, 212876220 United States, Massachusetts Massachusetts Gen Hosp Boston, Massachusetts, United States, 02114 United States, New York Columbia Presbyterian Hosp New York, New York, United States, 10032 AIDS TMT Unit / Univ Hosp Stonybrook, New York, United States, 117948153 United States, Tennessee Vanderbilt Clinic Nashville, Tennessee, United States, 37212 United States, Texas Oaklawn Physicians Group Dallas, Texas, United States, 75219 Less <<
NCT00018083 Tuberculosis ... More >>HIV Infections Less << Not Applicable Unknown - United States, North Carolina ... More >> Duke University Medical Center Recruiting Durham, North Carolina, United States, 27710 Contact: Carol D Hamilton, M.D.    919-684-3279 Less <<
NCT00002380 HIV Infections Phase 1 Completed - United States, New Jersey ... More >> Hoffmann - La Roche Inc Nutley, New Jersey, United States, 071101199 Less <<
NCT00002177 HIV Infections Not Applicable Completed - United States, California ... More >> Univ of California at San Francisco Gen Hosp San Francisco, California, United States, 94110 Less <<
NCT00002215 HIV Infections Not Applicable Completed - United States, Pennsylvania ... More >> Anderson Clinical Research Pittsburgh, Pennsylvania, United States, 15213 Less <<
NCT00001766 HIV Infection Phase 1 Completed - United States, Maryland ... More >> National Institute of Allergy and Infectious Diseases (NIAID) Bethesda, Maryland, United States, 20892 Less <<
NCT00017758 HIV Infections ... More >> HIV Seronegativity Lipodystrophy Less << Phase 1 Completed - United States, California ... More >> Stanford Univ Med Ctr Stanford, California, United States, 943055107 United States, Colorado Univ of Colorado Health Sciences Ctr Denver, Colorado, United States, 80262 United States, Maryland Johns Hopkins Hosp Baltimore, Maryland, United States, 21287 United States, Minnesota Univ of Minnesota Minneapolis, Minnesota, United States, 55455 United States, Missouri Washington Univ / St Louis Connect Care Saint Louis, Missouri, United States, 63108 Washington Univ School of Medicine St Louis, Missouri, United States, 63108 United States, New York Univ of Rochester Medical Center Rochester, New York, United States, 14642 United States, Ohio Univ of Cincinnati Cincinnati, Ohio, United States, 452670405 United States, Pennsylvania Univ of Pittsburgh Pittsburgh, Pennsylvania, United States, 15213 United States, Washington Univ of Washington Seattle, Washington, United States, 98104 Less <<
NCT02024009 Pancreatic Neoplasms (Locally ... More >>Advanced Non-metastatic) Less << Phase 1 Phase 2 Recruiting August 2020 United Kingdom ... More >> Oxford University Hospitals, Churchill Cancer Centre Recruiting Headington, Oxfordshire, United Kingdom, OX3 7LE Principal Investigator: Dr Somnath Mukherjee          Bristol Haematoloy and Oncology Centre Recruiting Bristol, United Kingdom, BS2 8ED Principal Investigator: Dr Stephen Falk          Addenbrookes Hospital Recruiting Cambridge, United Kingdom, CB2 0QQ Principal Investigator: Dr Thankamma Ajithkumar          Velindre Cancer Centre Recruiting Cardiff, United Kingdom, CF14 2TL Principal Investigator: Dr Seema Arif, Dr          Castle Hill Hospital Recruiting Cottingham, United Kingdom, HU16 5JQ Principal Investigator: Dr Rajarshi Roy          University Hospital Recruiting Coventry, United Kingdom, CV2 2DX Principal Investigator: Dr Martin Scott-Brown          Royal Surrey County Hospital Recruiting Guildford, United Kingdom, GU2 7XX Principal Investigator: Dr Sebastian Cummins          St James' Hospital Recruiting Leeds, United Kingdom Principal Investigator: Dr Ganesh Radhakrishna          University College London Hospital Not yet recruiting London, United Kingdom, NW1 2BU Principal Investigator: Dr John Bridgewater          Royal Free Hospital Recruiting London, United Kingdom, NW3 2PF Principal Investigator: Dr Roopinder Gillmore          Hammersmith Hospital Not yet recruiting London, United Kingdom, W12 0HS Principal Investigator: Dr Harpreet Wasan Less <<
NCT00000918 HIV Infections Phase 2 Completed - -
NCT00009061 HIV Infections Phase 3 Unknown - -
NCT00001094 HIV Infections Phase 2 Withdrawn - United States, California ... More >> Willow Clinic Menlo Park, California, United States, 94025 Stanford Univ Med Ctr Stanford, California, United States, 943055107 United States, Colorado Univ of Colorado Health Sciences Ctr Denver, Colorado, United States, 80262 United States, Florida Univ of Miami School of Medicine Miami, Florida, United States, 331361013 United States, Georgia Emory Univ Atlanta, Georgia, United States, 30308 United States, Hawaii Queens Med Ctr Honolulu, Hawaii, United States, 96816 Univ of Hawaii Honolulu, Hawaii, United States, 96816 United States, Illinois Louis A Weiss Memorial Hosp Chicago, Illinois, United States, 60640 United States, Louisiana Tulane Univ School of Medicine New Orleans, Louisiana, United States, 70112 United States, New York SUNY / Erie County Med Ctr at Buffalo Buffalo, New York, United States, 14215 Bellevue Hosp / New York Univ Med Ctr New York, New York, United States, 10016 United States, North Carolina Carolinas Med Ctr Charlotte, North Carolina, United States, 28203 Moses H Cone Memorial Hosp Greensboro, North Carolina, United States, 27401 United States, Ohio Univ of Cincinnati Cincinnati, Ohio, United States, 452670405 Ohio State Univ Hosp Clinic Columbus, Ohio, United States, 432101228 United States, Texas Univ of Texas Galveston Galveston, Texas, United States, 775550435 Puerto Rico Univ of Puerto Rico San Juan, Puerto Rico, 009365067 Less <<
NCT00001087 HIV Infections Phase 2 Completed - United States, Illinois ... More >> Northwestern University CRS Chicago, Illinois, United States, 60611 Cook County Hosp. CORE Ctr. Chicago, Illinois, United States, 60612 Rush Univ. Med. Ctr. ACTG CRS Chicago, Illinois, United States, 60612 United States, Maryland Johns Hopkins Adult AIDS CRS Baltimore, Maryland, United States, 21287 United States, New York NY Univ. HIV/AIDS CRS New York, New York, United States Puerto Rico Puerto Rico-AIDS CRS San Juan, Puerto Rico, 009365067 Less <<
NCT00004985 HIV Infections Phase 2 Completed - -
NCT00000903 HIV Infections Phase 3 Completed - -
NCT00006211 HIV Infections Phase 2 Completed - United States, California ... More >> Lisa Bauman San Diego, California, United States, 92121 Less <<
NCT00008554 HIV Infections Phase 3 Unknown - United States, California ... More >> East Bay Clinical Trial Ctr Concord, California, United States, 94520 Ocean View Internal Medicine Long Beach, California, United States, 90803 United States, Florida Florida ID Group Orlando, Florida, United States, 32801 Hillsborough County Health Dept Tampa, Florida, United States, 33602 Clinical Pharmacology Services Tampa, Florida, United States, 33617 United States, Illinois Veterans Affairs Med Ctr of North Chicago Chicago, Illinois, United States, 60064 United States, Kansas Univ of Kansas Med Ctr Kansas City, Kansas, United States, 661607415 United States, New Jersey Saint Michael's Med Ctr Newark, New Jersey, United States, 07102 UMDNJ - New Jersey Med School Newark, New Jersey, United States, 071032757 United States, New York Bronx Municipal Hosp Ctr/Jacobi Med Ctr Bronx, New York, United States, 10461 Addiction Research and Treatment Corp Brooklyn, New York, United States, 11201 Brookdale Univ Hosp and Med Ctr Brooklyn, New York, United States, 112123198 Gervais Frechette New York, New York, United States, 10011 Howard Grossman New York, New York, United States, 10011 Mount Sinai School of Medicine New York, New York, United States, 10029 Univ of Rochester Med Ctr Rochester, New York, United States, 14642 United States, North Carolina SMO-USA Inc Charlotte, North Carolina, United States, 28211 United States, Oregon Advanced Clinical Trials Inc Eugene, Oregon, United States, 97401 United States, Pennsylvania Thomas Jefferson Univ Philadelphia, Pennsylvania, United States, 19107 United States, Texas Univ of Texas Med Branch Galveston, Texas, United States, 775550835 MacGregor Med Association Houston, Texas, United States, 77054 Walter Gaman Irving, Texas, United States, 75038 Southwest Texas Methodist Hosp San Antonio, Texas, United States, 78229 Less <<
NCT00385450 Cardiopulmonary Bypass Phase 1 Terminated(Study closed at May... More >>o prior to completion) Less << - United States, Minnesota ... More >> Mayo Clinic Rochester, Minnesota, United States, 55905 Less <<
NCT00006326 HIV Infections Not Applicable Terminated - United States, California ... More >> Susan Conner San Diego, California, United States, 92121 Less <<
NCT00000887 HIV Infections ... More >> Pregnancy Less << Phase 1 Completed - United States, California ... More >> Usc La Nichd Crs Los Angeles, California, United States, 90033 United States, Louisiana Tulane Univ. Health Science Ctr., Tulane Univ. Hosp. & Clinic New Orleans, Louisiana, United States, 701122699 Tulane/LSU Maternal/Child CRS New Orleans, Louisiana, United States, 70112 United States, Maryland Johns Hopkins Hosp. & Health System - Dept. of Peds., Div. of Infectious Diseases Baltimore, Maryland, United States, 212874933 United States, Massachusetts HMS - Children's Hosp. Boston, Div. of Infectious Diseases Boston, Massachusetts, United States, 021155724 United States, North Carolina UNC at Chapel Hill School of Medicine - Dept. of Peds., Div. of Immunology & Infectious Diseases Chapel Hill, North Carolina, United States, 27710 United States, Pennsylvania St. Christopher's Hosp. for Children Philadelphia, Pennsylvania, United States, 191341095 Less <<
NCT00005000 HIV Infections Phase 4 Unknown - United States, California ... More >> Agouron Pharmaceuticals Inc San Diego, California, United States, 92121 Less <<
NCT00004999 HIV Infections Phase 2 Suspended - -
NCT00002219 HIV Infections Phase 2 Unknown - United States, Florida ... More >> All Children's Hosp St. Petersburg, Florida, United States, 33731 United States, Louisiana Tulane Univ Med Ctr / Dept of Pediatrics New Orleans, Louisiana, United States, 70112 United States, New York Bronx Lebanon Hosp Ctr / Dept of Pediatrics Bronx, New York, United States, 10457 North Shore Univ Hosp / Division of Immunology Great Neck, New York, United States, 11021 St Lukes Roosevelt Hosp Ctr New York, New York, United States, 10025 United States, North Carolina Duke Univ Med Ctr / Duke South Hosp Durham, North Carolina, United States, 27710 United States, South Carolina Med Univ of South Carolina Charleston, South Carolina, United States, 29425 Less <<
NCT00002235 HIV Infections Phase 2 Completed - United States, California ... More >> Pacific Oaks Med Group Beverly Hills, California, United States, 90211 United States, Colorado Univ of Colorado / Health Science Ctr Denver, Colorado, United States, 80262 United States, Georgia AIDS Research Consortium of Atlanta Atlanta, Georgia, United States, 30308 United States, Rhode Island Brown Univ School of Medicine Providence, Rhode Island, United States, 02908 United States, Virginia Hampton Roads Med Specialists Hampton, Virginia, United States, 23666 Less <<
NCT00002381 HIV Infections Phase 1 Completed - United States, California ... More >> Saint Francis Mem Hosp / HIV Care Unit San Francisco, California, United States, 94109 United States, Rhode Island Roger Williams Med Ctr Providence, Rhode Island, United States, 02908 Less <<
NCT00028067 HIV Infections Phase 3 Terminated - -
NCT00002170 Mycobacterium Avium-Intracellu... More >>lare Infection HIV Infections Less << Phase 2 Completed - United States, California ... More >> Univ of California / San Diego Treatment Ctr San Diego, California, United States, 92103 Harbor UCLA Med Ctr Torrance, California, United States, 90502 United States, Illinois Rush Presbyterian - Saint Luke's Med Ctr Chicago, Illinois, United States, 60612 United States, Massachusetts Boston VA Med Ctr / 151 Boston, Massachusetts, United States, 02730 United States, Texas Baylor Univ Houston, Texas, United States, 77009 Less <<
NCT00000859 HIV Infections Not Applicable Completed - -
NCT00541463 HIV Infections Phase 2 Completed - -
NCT00589056 Lung Cancer Phase 1 Phase 2 Unknown - United States, Pennsylvania ... More >> Abramson Cancer Center of the University of Pennsylvania Philadelphia, Pennsylvania, United States, 19104-4283 Less <<
NCT00002169 Cytomegalovirus Retinitis ... More >> HIV Infections Less << Phase 2 Completed - United States, California ... More >> Univ of Southern California / LA County USC Med Cntr Los Angeles, California, United States, 90033 Univ of California / UCI Med Ctr Orange, California, United States, 92868 Univ of California / San Diego Treatment Ctr San Diego, California, United States, 92103 Harbor UCLA Med Ctr Torrance, California, United States, 90502 United States, District of Columbia George Washington Univ Washington, District of Columbia, United States, 20037 United States, Illinois Northwestern Univ / SOCA Chicago, Illinois, United States, 60611 United States, Texas Univ of Texas Med Branch Galveston, Texas, United States, 77555 Baylor Univ Houston, Texas, United States, 77009 Less <<
NCT00146380 HIV Infections Phase 2 Unknown January 2013 Kenya ... More >> CDC Clincical Research Center Kisumu, Kenya Less <<
NCT00000898 HIV Infections Not Applicable Completed - United States, California ... More >> San Francisco Gen Hosp San Francisco, California, United States, 941102859 Univ of California/ San Francisco / Dept of Medicine San Francisco, California, United States, 94110 Stanford Univ Med Ctr Stanford, California, United States, 943055107 United States, Maryland Johns Hopkins Hosp Baltimore, Maryland, United States, 21287 Less <<
NCT00002171 HIV Infections Phase 2 Completed - United States, Alabama ... More >> Univ of Alabama at Birmingham Birmingham, Alabama, United States, 35294 United States, California Univ of Southern California / LA County USC Med Cntr Los Angeles, California, United States, 90033 United States, Louisiana HIV Outpatient Clinics / LA State Univ Med Ctr New Orleans, Louisiana, United States, 70112 United States, Texas Baylor Univ Houston, Texas, United States, 77009 Less <<
NCT00002185 Sarcoma, Kaposi ... More >> HIV Infections Less << Phase 2 Completed - United States, California ... More >> LAC and USC Med Ctr / School of Medicine Los Angeles, California, United States, 90033 Univ of California / UCI Med Ctr Orange, California, United States, 92868 UCSD Treatment Ctr San Diego, California, United States, 92103 Santa Clara Valley Med Ctr San Jose, California, United States, 951282699 Harbor - UCLA Med Ctr - Box 449 Torrance, California, United States, 90509 Less <<
NCT01959672 Pancreatic Adenocarcinoma ... More >> Resectable Pancreatic Carcinoma Stage I Pancreatic Cancer Stage IA Pancreatic Cancer Stage IB Pancreatic Cancer Stage II Pancreatic Cancer Stage IIA Pancreatic Cancer Stage IIB Pancreatic Cancer Stage III Pancreatic Cancer Less << Phase 2 Active, not recruiting December 2019 United States, Nebraska ... More >> University of Nebraska Medical Center Omaha, Nebraska, United States, 68198 Less <<
NCT00002164 HIV Infections Phase 1 Completed - United States, California ... More >> UCLA School of Medicine / Dept of Pediatrics Los Angeles, California, United States, 90024 Less <<
NCT00002165 HIV Infections Not Applicable Completed - United States, California ... More >> Agouron Pharmaceuticals Inc San Diego, California, United States, 92121 Less <<
NCT00650637 Diarrhea Phase 3 Terminated(The study was prema... More >>turely discontinued due to administrative reasons on August 18, 2003. There were no safety concerns that led to the decision to terminate.) Less << - United States, Alabama ... More >> Pfizer Investigational Site Birmingham, Alabama, United States, 35233 United States, Florida Pfizer Investigational Site Ft. Lauderdale, Florida, United States, 33308 United States, New York Pfizer Investigational Site New York, New York, United States, 10011 United States, North Carolina Pfizer Investigational Site Huntersville, North Carolina, United States, 28078 United States, Texas Pfizer Investigational Site Austin, Texas, United States, 78705 Pfizer Investigational Site Houston, Texas, United States, 77098 Less <<
NCT00915694 Brain and Central Nervous Syst... More >>em Tumors Less << Phase 1 Unknown - United States, Pennsylvania ... More >> Abramson Cancer Center of the University of Pennsylvania Philadelphia, Pennsylvania, United States, 19104-4283 Less <<
NCT00000893 HIV Infections Phase 1 Completed - -
NCT01020292 Glioma PHASE1 COMPLETED 2025-12-17 Abramson Cancer Center of the ... More >>University of Pennsylvania, Philadelphia, Pennsylvania, 19104, United States Less <<
NCT00233948 Adult Liposarcoma ... More >> Recurrent Adult Soft Tissue Sarcoma Stage III Adult Soft Tissue Sarcoma Stage IV Adult Soft Tissue Sarcoma Less << Phase 1 Phase 2 Terminated(Drug availability i... More >>ssues) Less << - United States, California ... More >> City of Hope Medical Center Duarte, California, United States, 91010 South Pasadena Cancer Center Pasadena, California, United States, 91030 Less <<
NCT00002375 HIV Infections Not Applicable Completed - United States, Alabama ... More >> Univ of Alabama at Birmingham Birmingham, Alabama, United States, 35294 United States, California UCSD Treatment Ctr / Dept of Medicine and Pediatrics San Diego, California, United States, 92103 United States, Pennsylvania Univ of Pittsburgh / Graduate School of Public Health Pittsburgh, Pennsylvania, United States, 15261 Less <<
NCT01068327 Adenocarcinoma of the Pancreas... More >> Stage III Pancreatic Cancer Less << Phase 1 Active, not recruiting April 2019 United States, Nebraska ... More >> University of Nebraska Medical Center Omaha, Nebraska, United States, 68198 Less <<
NCT00233948 - Terminated(Drug availability i... More >>ssues) Less << - -
NCT00002201 HIV Infections Not Applicable Completed - United States, Maryland ... More >> Johns Hopkins Hosp Baltimore, Maryland, United States, 21287 Less <<
NCT00346619 Immune Response PHASE1 COMPLETED 2025-10-07 Mayo Clinic, Rochester, Minnes... More >>ota, 55905, United States Less <<
NCT02207439 Stage III, IVa, or IVb Squamou... More >>s Cell Carcinoma of the Oral Cavity, Oropharynx, Larynx, or Hypopharynx Less << Phase 2 Recruiting - United States, Pennsylvania ... More >> Abramson Cancer Center of the University of Pennsylvania Recruiting Philadelphia, Pennsylvania, United States, 19104 Contact: Dana Patsch    215-615-5645    Dana.Patsch@uphs.upenn.edu    Principal Investigator: Alexander Lin, MD Less <<
NCT00141284 HIV Infection ... More >> Hepatitis C Less << Phase 4 Completed - United States, California ... More >> Pfizer Investigational Site Bakersfield, California, United States, 93301 United States, Florida Pfizer Investigational Site Miami, Florida, United States, 33136 United States, Louisiana Pfizer Investigational Site Shreveport, Louisiana, United States, 71130 United States, Texas Pfizer Investigational Site Dallas, Texas, United States, 75390 Canada, Ontario Pfizer Investigational Site Toronto, Ontario, Canada, M5G 2C4 Less <<
NCT00023400 HIV Infections ... More >> Tuberculosis Less << Phase 4 Completed - -
NCT03050060 Metastatic Renal Cell Cancer ... More >> Recurrent Melanoma Recurrent Non-Small Cell Lung Carcinoma Recurrent Renal Cell Carcinoma Stage IV Cutaneous Melanoma AJCC v6 and v7 Stage IV Non-Small Cell Lung Cancer AJCC v7 Stage IV Renal Cell Cancer AJCC v7 Less << Phase 2 Recruiting December 1, 2021 United States, Washington ... More >> Fred Hutch/University of Washington Cancer Consortium Recruiting Seattle, Washington, United States, 98109 Contact: Ramesh Rengan    206-598-4100    rengan@uw.edu    Principal Investigator: Ramesh Rengan Less <<
NCT00312182 Healthy Volunteers PHASE4 COMPLETED 2025-06-06 Pfizer Investigational Site, N... More >>ew Haven, Connecticut, 06511-5473, United States|Pfizer Investigational Site, Ann Arbor, Michigan, 48105, United States|Pfizer Investigational Site, Bruxelles, B-1070, Belgium|Pfizer Investigational Site, Singapore, 169608, Singapore Less <<
NCT00251030 Healthy Volunteers Phase 4 Completed - United States, Michigan ... More >> Pfizer Investigational Site Kalamazoo, Michigan, United States, 49007 Less <<
NCT01108666 Non Small Cell Lung Cancer PHASE2 TERMINATED 2025-12-18 Abramson Cancer Center of the ... More >>University of Pennsylvania, Philadelphia, Pennsylvania, 19104, United States Less <<
NCT00694837 Glioblastoma Phase 1 Completed - Netherlands ... More >> Maastricht Radiation Oncology Maastricht, Netherlands, 6202 AZ Less <<
NCT02363829 Uterine Cervix Cancer Phase 1 Recruiting February 2020 United States, Pennsylvania ... More >> Abramson Cancer Center of the University of Pennsylvania Recruiting Philadelphia, Pennsylvania, United States, 19104 Principal Investigator: Fiona Simpkins, MD Less <<
NCT01445106 Solid Tumors Phase 1 Completed - United States, Maryland ... More >> National Institutes of Health Clinical Center, 9000 Rockville Pike Bethesda, Maryland, United States, 20892 Less <<
NCT01086332 Pancreatic Neoplasms Phase 1 Terminated(Toxicities, lack of... More >> funding) Less << - -
NCT01164709 Leukemia Lymp... More >>homa Mature T-cell and Nk-cell Neoplasms Multiple Myeloma and Plasma Cell Neoplasm Less << Phase 1 Completed - Switzerland ... More >> Inselspital Bern Bern, Switzerland, CH-3010 Kantonsspital Graubuenden Chur, Switzerland, CH-7000 Centre Hospitalier Universitaire Vaudois Lausanne, Switzerland, CH-1011 Kantonsspital - St. Gallen St. Gallen, Switzerland, CH-9007 Less <<
NCT00791336 Carcinoma, Non-Small-Cell Lung PHASE2 TERMINATED 2025-03-11 The University of Iowa Departm... More >>ent of Radiation Oncology, Iowa City, Iowa, 52242, United States Less <<
NCT00205283 HIV Infections COMPLETED 2005-08-01 University of Wisconsin Hospit... More >>al and Clinics, Madison, Wisconsin, 53792, United States Less <<
NCT01555281 Multiple Myeloma Phase 1 Phase 2 Active, not recruiting December 2019 Italy ... More >> Istituto Europeo di Oncologia IEO Milano, Italy, 20141 University of Torino Torino, Italy, 10127 Switzerland Kantonsspital Aarau Aarau, Switzerland, 5001 Kantonsspital Baden Baden, Switzerland, 5404 Istituto Oncologico Svizzera Italiana IOSI Bellinzona, Switzerland, 6500 Inselspital Bern Bern, Switzerland, 3010 Kantonsspital Graubünden Chur, Switzerland, 7000 Kantonsspital Olten Olten, Switzerland, 4600 Kantonsspital St. Gallen St. Gallen, Switzerland, 9007 Regionalspital Thun, Switzerland, 3600 UniversitätsSpital Zürich Zürich, Switzerland, 8091 Less <<
NCT01485731 Cervical Cancer Phase 1 Completed - United States, Florida ... More >> University of Miami Miami, Florida, United States, 33136 Less <<
NCT00246610 HIV Infection Phase 4 Completed - United States, Florida ... More >> Pfizer Investigational Site Jacksonville, Florida, United States, 32209 Pfizer Investigational Site Miami, Florida, United States, 33136 United States, Louisiana Pfizer Investigational Site Metairie, Louisiana, United States, 70006 United States, Michigan Pfizer Investigational Site Detroit, Michigan, United States, 48201 United States, Pennsylvania Pfizer Investigational Site Philadelphia, Pennsylvania, United States, 19410 Canada, Ontario Pfizer Investigational Site Toronto, Ontario, Canada, M5G 2N2 Less <<
NCT03256916 Carcinoma Cervix, Stage III Phase 3 Not yet recruiting September 30, 2025 India ... More >> Tata Memorial Centre Not yet recruiting Mumbai, Maharashtra, India, 400012 Contact: Supriya J Sastri, MD    9930958309    supriyasastri@gmail.com    Contact: Jayant Goda, MD    24177000 ext 7027    godajayantsastri@gmail.com    Principal Investigator: Supriya J Sastri, MD          Principal Investigator: Jayant Goda, MD Less <<
NCT01079286 Renal Cell Cancer ... More >> Cancer Less << Phase 1 Completed - Netherlands ... More >> Academic Medical Center Amsterdam, Netherlands, 1105AZ Less <<
NCT00791336 Carcinoma, Non-Small-Cell Lung PHASE2 TERMINATED 2025-03-11 The University of Iowa Departm... More >>ent of Radiation Oncology, Iowa City, Iowa, 52242, United States Less <<
NCT01728779 Oligometastases Phase 2 Active, not recruiting July 2021 United States, Maryland ... More >> The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins Baltimore, Maryland, United States, 21231 Less <<
NCT01065844 Carcinoma, Adenoid Cystic|Head... More >> and Neck Neoplasms Less << PHASE2 COMPLETED 2025-11-17 The Holden Comprehensive Cance... More >>r Center, Iowa City, Iowa, 52242, United States Less <<
NCT01065844 Carcinoma, Adenoid Cystic|Head... More >> and Neck Neoplasms Less << PHASE2 COMPLETED 2025-11-17 The Holden Comprehensive Cance... More >>r Center, Iowa City, Iowa, 52242, United States Less <<
NCT00704600 Colorectal Cancer ... More >> Colorectal Carcinoma Colorectal Tumors Neoplasms, Colorectal Less << Phase 1 Phase 2 Completed - Netherlands ... More >> Maastro clinic Maastricht, Netherlands, 6229 ET Less <<
NCT01447589 Lung Cancer Phase 1 Phase 2 Withdrawn(failed to recruit, n... More >>o suitable patients) Less << - United Kingdom ... More >> Oxford Radcliffe NHS Trust Oxford, Oxfordshire, United Kingdom, OX3 9DU Less <<
NCT02188537 Myeloma Phase 2 Completed - Switzerland ... More >> Kantonsspital Aarau Aarau, Switzerland, CH-5001 Kantonsspital Baden Baden, Switzerland, 5404 Universitaetsspital-Basel Basel, Switzerland, CH-4031 Istituto Oncologico Svizzera Italiana IOSI Bellinzona, Switzerland, 6500 Inselspital Bern Bern, Switzerland, 3010 Kantonsspital Graubuenden Chur, Switzerland, CH-7000 Hopital Fribourgeois Fribourg, Switzerland, 1708 Hopital Cantonal Universitaire de Geneve Geneva, Switzerland, CH-1211 Centre Hospitalier Universitaire Vaudois Lausanne, Switzerland, CH-1011 Kantonsspital - St. Gallen St. Gallen, Switzerland, CH-9007 SpitalSTS AG Simmental-Thun-Saanenland Thun, Switzerland, 3600 UniversitätsSpital Zürich Zürich, Switzerland, 8091 Less <<
NCT02066311 Systemic Lupus Erythematosus PHASE2 TERMINATED 2025-06-18 Cedars-Sinai Medical Center, L... More >>os Angeles, California, 90048, United States|UCLA David Geffen School of Medicine, Los Angeles, California, 90095, United States|Rush University Medical Center, Chicago, Illinois, 60612, United States|Bronx Lebanon Hospital, Bronx, New York, 10457, United States|The Feinstein Institute for Medical Research, Manhasset, New York, 11030, United States|New York University School of Medicine, New York, New York, 10016, United States|Columbia University Medical Center, New York, New York, 10032, United States|Hospital for Special Surgery, New York, New York, 20021, United States Less <<
NCT01925378 Cervical Dysplasia PHASE2 WITHDRAWN 2025-12-22 The University of Texas Health... More >> Science Center at Houston, Houston, Texas, 77030, United States Less <<
NCT03077451 Recurrent Kaposi Sarcoma ... More >> Skin Kaposi Sarcoma Less << Phase 2 Recruiting November 2019 United States, California ... More >> UCLA Clinical AIDS Research and Education (CARE) Center Recruiting Los Angeles, California, United States, 90095-1793 Contact: Maricela Gonzalez    310-557-3729    mmgonzalez@mednet.ecla.edu    Principal Investigator: Ronald Mitsuyasu, MD          United States, Maryland Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins Recruiting Baltimore, Maryland, United States, 21231-2410 Contact: Clinical Trials Office - Sidney Kimmel Comprehensive Cancer Ce    410-955-8804    jhcccro@jhmi.edu    Principal Investigator: Richard Ambinder, MD          United States, Massachusetts Beth Israel Deaconess Medical Center Recruiting Boston, Massachusetts, United States, 02215 Contact: Erin Sullivan, NP    617-667-3087    Esulliv1@bidmc.harvard.edu    Principal Investigator: Ayad Hamdan, MD          United States, Missouri Washington University School of Medicine Recruiting Saint Louis, Missouri, United States, 63110 Contact: Lee Ratner, MD    800-600-3606    info@sitman.wustl.edu    Principal Investigator: Lee Ratner, MD          United States, New York Memorial Sloan Kettering Cancer Center Recruiting New York, New York, United States, 10065 Contact: Mark Dickson, MD    646-888-4164    dicksonm@mskcc.org    Principal Investigator: Mark Dickson, MD          United States, Ohio Ohio State University Recruiting Columbus, Ohio, United States, 43210 Contact: Lisa Brenner    614-293-7843    Lisa.Brenner@osumc.edu    Principal Investigator: Robert Baiocchi, MD          United States, Pennsylvania Fox Chase Cancer Center Recruiting Philadelphia, Pennsylvania, United States, 19111 Contact: Stefan Barta, MD    215-728-2674    Stefan.barta@fccc.edu    Principal Investigator: Stefan Barta, MD          United States, Washington Benaroya Research Institute at Virginia Mason Medical Center Recruiting Seattle, Washington, United States, 98101 Contact: Clinical Trials Office - Benaroya Research Institute    206-583-6526    hemdma@vmmc.org    Contact: David Aboulafia, MD       hemdma@vmmc.org    Principal Investigator: David Aboulafia, MD          Harborview Medical Center Recruiting Seattle, Washington, United States, 98104 Contact: Alison Kunze    206-744-5828    kunzea@uw.edu    Principal Investigator: Manoj Menon, MD          Uganda Uganda Cancer Institute Not yet recruiting Kampala, Uganda Contact: Jackson Orem, MD          Principal Investigator: Jackson Orem, MD Less <<
NCT03422874 Neoplasms Lym... More >>phoma Less << Phase 1 Withdrawn(Sponsor withdrew sup... More >>port) Less << August 4, 2017 United States, New Hampshire ... More >> Dartmouth-Hitchcock Medical Center Lebanon, New Hampshire, United States, 03756 Less <<
NCT02080416 Non-Hodgkin Lymphoma|Hodgkin L... More >>ymphoma|Kaposi Sarcoma|Gastric Cancer|Nasopharyngeal Cancer|EBV|Castleman Disease Less << EARLY_PHASE1 TERMINATED 2025-02-16 The Sidney Kimmel Comprehensiv... More >>e Cancer Center at Johns Hopkins, Baltimore, Maryland, 21287, United States Less <<

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

1.76mL

0.35mL

0.18mL

8.81mL

1.76mL

0.88mL

17.61mL

3.52mL

1.76mL

Dissolving Methods
Please choose the appropriate dissolution scheme according to your animal administration guide.For the following dissolution schemes, clear stock solution should be prepared according to in vitro experiments, and then cosolvent should be added in turn:

in order to ensure the reliability of the experimental results, the clarified stock solution can be properly preserved according to the storage conditions; The working fluid for in vivo experiment is recommended to be prepared now and used on the same day;

The percentage shown in front of the following solvent refers to the volume ratio of the solvent in the final solution; If precipitation or precipitation occurs in the preparation process, it can be assisted by heating and/or ultrasound.
Protocol 1
Protocol 2

References

 

Historical Records

Categories