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The BI-3802 was designed by Boehringer Ingelheim and could be obtained free of charge through the Boehringer Ingelheim open innovation portal opnMe.com, associated with its negative control.
Synonyms: N-(+)-Biotinyl-6-aminohexanoic acid
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Batch number can be found on the product's label following the word 'Batch'.
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Batch number can be found on the product's label following the word 'Batch'.
Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.
Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.
Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.
CAS No. : | 72040-64-3 |
Formula : | C16H27N3O4S |
M.W : | 357.47 |
SMILES Code : | O=C(O)CCCCCNC(CCCC[C@@H]1SC[C@]([C@]1([H])N2)([H])NC2=O)=O |
Synonyms : |
N-(+)-Biotinyl-6-aminohexanoic acid
|
MDL No. : | MFCD00144853 |
InChI Key : | CMUGHZFPFWNUQT-HUBLWGQQSA-N |
Pubchem ID : | 446905 |
GHS Pictogram: |
![]() |
Signal Word: | Warning |
Hazard Statements: | H302-H315-H319-H335 |
Precautionary Statements: | P261-P305+P351+P338 |
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
58.3% | With lithium hydroxide monohydrate; In methanol;Reflux; | Lithium hydroxide (4equiv) solution was added to 6 (1equiv) dissolved in methanol. The solution was heated to reflux overnight. The product 7 was precipitated as white solid. Then a hydrochloric acid solution (6 N) was added until the pH was 5. The product was filtered, and dried under vacuum. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
39% | With dmap; diisopropyl-carbodiimide; In N,N-dimethyl-formamide; at 20℃; for 48h;Inert atmosphere; | General procedure: To a mixture of Biotin or 6-biotinylaminocaproic acid (0.3 mmol), camptothecin analogues (0.1 mmol) and DMF (2.5 mL) was added, 4-Dimethylaminopyridine (DMAP) (0.01 mmol) was added and N, N'-Diisopropylcarbodiimide) (DIC) (0.6 mmol) dropwise. The reaction mixture was stirred at room temperature for 2 days under N2. Solvent were removed under a reduced. The residue was purified on a silica gel chromatography (CHCl3:CH3OH = 15:1?9:1) to afford the product Biotin-(20s)-camptothecin (11). Yellow amorphous powder, yield 60percent; |