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Chemical Structure| 72040-64-3 Chemical Structure| 72040-64-3
Chemical Structure| 72040-64-3

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Synonyms: N-(+)-Biotinyl-6-aminohexanoic acid

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Product Details of N-Biotinyl-6-aminohexanoic acid

CAS No. :72040-64-3
Formula : C16H27N3O4S
M.W : 357.47
SMILES Code : O=C(O)CCCCCNC(CCCC[C@@H]1SC[C@]([C@]1([H])N2)([H])NC2=O)=O
Synonyms :
N-(+)-Biotinyl-6-aminohexanoic acid
MDL No. :MFCD00144853
InChI Key :CMUGHZFPFWNUQT-HUBLWGQQSA-N
Pubchem ID :446905

Safety of N-Biotinyl-6-aminohexanoic acid

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Application In Synthesis of N-Biotinyl-6-aminohexanoic acid

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 72040-64-3 ]

[ 72040-64-3 ] Synthesis Path-Downstream   1~35

  • 1
  • 12-aminododecanoic acid methyl ester hydrochloride [ No CAS ]
  • [ 72040-64-3 ]
  • [ 223733-85-5 ]
  • 2
  • [ 170892-94-1 ]
  • [ 72040-64-3 ]
  • Biotinylaminocaproyl-L-methionylglycyl-L-leucyl-L-prolyl-(S-farnesyl)-L-cysteine methyl ester [ No CAS ]
  • 3
  • Glycyl-(S-palmitoyl)-L-cysteine allyl ester hydrotrifluoroacetate [ No CAS ]
  • [ 72040-64-3 ]
  • Biotinylaminocaproyl-glycyl-(S-palmitoyl)-L-cysteine allyl ester [ No CAS ]
  • 4
  • [ 72040-64-3 ]
  • Glycyl-(S-hexadecyl)-L-cysteine allyl ester hydrotrifluoroacetate [ No CAS ]
  • Biotinylaminocaproyl-glycyl-(S-hexadecyl)-L-cysteine allyl ester [ No CAS ]
  • 5
  • [ 72040-64-3 ]
  • poly(sebacic acid) [ No CAS ]
  • fluorescein-conjugated avidin [ No CAS ]
  • 6-((biotinoyl)amino)hexanoic acid-attached poly(sebacic acid) microspheres [ No CAS ]
  • 6
  • methyl 6-(+)-biotinylamidohexanoate [ No CAS ]
  • [ 72040-64-3 ]
YieldReaction ConditionsOperation in experiment
58.3% With lithium hydroxide monohydrate; In methanol;Reflux; Lithium hydroxide (4equiv) solution was added to 6 (1equiv) dissolved in methanol. The solution was heated to reflux overnight. The product 7 was precipitated as white solid. Then a hydrochloric acid solution (6 N) was added until the pH was 5. The product was filtered, and dried under vacuum.
  • 7
  • [ 4136-95-2 ]
  • [ 72040-64-3 ]
  • C23H28Cl3N3O5S [ No CAS ]
  • 8
  • [ 162827-97-6 ]
  • [ 72040-64-3 ]
  • [ 721431-24-9 ]
  • 9
  • [ 66534-97-2 ]
  • [ 72040-64-3 ]
  • 5-(2-oxohexahydrothieno[3,4-d]imidazol-6-yl)pentanoic acid {5-[bis(2-diphenylphosphanyl-ethyl)carbamoyl]pentyl}amide [ No CAS ]
  • 10
  • [ 144085-40-5 ]
  • [ 72040-64-3 ]
  • 6-[5-(2-oxohexahydrothieno[3,4-d]imidazol-4-yl)pentanoylamino]hexanoic acid {3-diphenylphosphanyl-2-[(diphenylphosphanyl)methyl]-2-methylpropyl}amide [ No CAS ]
  • 11
  • [ 72040-64-3 ]
  • [ 774183-16-3 ]
  • methyl 2-cyano-23-[6-({5-[(3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentanoyl}amino)hexanoyl]oxy-3,12-dioxooleana-1,9(11)-dien-28-oate [ No CAS ]
  • 12
  • [ 58-85-5 ]
  • [ 60-32-2 ]
  • [ 72040-64-3 ]
  • 13
  • [ 7689-03-4 ]
  • [ 72040-64-3 ]
  • 6-biotinylaminocaproic acid-(20s)-camptothecin [ No CAS ]
YieldReaction ConditionsOperation in experiment
39% With dmap; diisopropyl-carbodiimide; In N,N-dimethyl-formamide; at 20℃; for 48h;Inert atmosphere; General procedure: To a mixture of Biotin or 6-biotinylaminocaproic acid (0.3 mmol), camptothecin analogues (0.1 mmol) and DMF (2.5 mL) was added, 4-Dimethylaminopyridine (DMAP) (0.01 mmol) was added and N, N'-Diisopropylcarbodiimide) (DIC) (0.6 mmol) dropwise. The reaction mixture was stirred at room temperature for 2 days under N2. Solvent were removed under a reduced. The residue was purified on a silica gel chromatography (CHCl3:CH3OH = 15:1?9:1) to afford the product Biotin-(20s)-camptothecin (11). Yellow amorphous powder, yield 60percent;
  • 14
  • glycine rapamycin ester [ No CAS ]
  • [ 72040-64-3 ]
  • C69H107N5O17S [ No CAS ]
  • 15
  • [ 56-41-7 ]
  • [ 72040-64-3 ]
  • (S)-2-{6-[5-((3aR,6S,6aS)-2-Oxo-hexahydro-thieno[3,4-d]imidazol-6-yl)-pentanoylamino]-hexanoylamino}-propionic acid [ No CAS ]
  • 16
  • [ 61-90-5 ]
  • [ 72040-64-3 ]
  • (S)-4-Methyl-2-{6-[5-((3aR,6S,6aS)-2-oxo-hexahydro-thieno[3,4-d]imidazol-6-yl)-pentanoylamino]-hexanoylamino}-pentanoic acid [ No CAS ]
  • 17
  • [ 63-68-3 ]
  • [ 72040-64-3 ]
  • [ 217655-55-5 ]
  • 18
  • [ 56-85-9 ]
  • [ 72040-64-3 ]
  • (S)-4-Carbamoyl-2-{6-[5-((3aR,6S,6aS)-2-oxo-hexahydro-thieno[3,4-d]imidazol-6-yl)-pentanoylamino]-hexanoylamino}-butyric acid [ No CAS ]
  • 19
  • [ 74-79-3 ]
  • [ 72040-64-3 ]
  • (S)-5-Guanidino-2-{6-[5-((3aR,6S,6aS)-2-oxo-hexahydro-thieno[3,4-d]imidazol-6-yl)-pentanoylamino]-hexanoylamino}-pentanoic acid [ No CAS ]
  • 20
  • [ 63-91-2 ]
  • [ 72040-64-3 ]
  • (S)-2-{6-[5-((3aR,6S,6aS)-2-Oxo-hexahydro-thieno[3,4-d]imidazol-6-yl)-pentanoylamino]-hexanoylamino}-3-phenyl-propionic acid [ No CAS ]
  • 21
  • [ 912557-14-3 ]
  • [ 72040-64-3 ]
  • [(S)-2-((S)-3-Methyl-2-{6-[5-((3aR,6S,6aS)-2-oxo-hexahydro-thieno[3,4-d]imidazol-6-yl)-pentanoylamino]-hexanoylamino}-butyrylamino)-propionylamino]-acetic acid (2E,4E)-hexa-2,4-dienyl ester [ No CAS ]
  • 22
  • [ 861640-70-2 ]
  • [ 72040-64-3 ]
  • [ 861640-71-3 ]
  • 23
  • p-aminophenyl 5-acetamido-3,5-dideoxy-D-glycero-α-D-galacto-nonulosyl-2-onic acid-(2->3)-β-D-galactopyranoside-(1->4)-2-acetamido-2-deoxy-β-D-glucopyranoside [ No CAS ]
  • [ 72040-64-3 ]
  • [(6-biotinylamido)hexanoylamido]-phenyl 5-acetamido-3,5-dideoxy-D-glycero-α-D-galacto-nonulosyl-2-onic acid-(2->3)-β-D-galactopyranoside-(1->4)-2-acetamido-2-deoxy-β-D-glucopyranoside [ No CAS ]
  • 24
  • p-aminophenyl 5-acetamido-3,5-dideoxy-D-glycero-α-D-galacto-nonulosyl-2-onic acid-(2->6)-β-D-galactopyranoside-(1->4)-2-acetamido-2-deoxy-β-D-glucopyranoside [ No CAS ]
  • [ 72040-64-3 ]
  • [(6-biotinylamido)hexanoylamido]-phenyl 5-acetamido-3,5-dideoxy-D-glycero-α-D-galacto-nonulosyl-2-onic acid-(2->6)-β-D-galactopyranoside-(1->4)-2-acetamido-2-deoxy-β-D-glucopyranoside [ No CAS ]
  • 25
  • C21H22N2O2 [ No CAS ]
  • [ 72040-64-3 ]
  • C37H47N5O5S [ No CAS ]
  • 26
  • [ 72040-64-3 ]
  • (S)-4-Methylsulfanyl-2-{6-[5-((3aR,6S,6aS)-2-oxo-hexahydro-thieno[3,4-d]imidazol-6-yl)-pentanoylamino]-hexanoylamino}-butyric acid 4-nitro-phenyl ester [ No CAS ]
  • 27
  • [ 72040-64-3 ]
  • (S)-4-Methylsulfanyl-2-{6-[5-((3aR,6S,6aS)-2-oxo-hexahydro-thieno[3,4-d]imidazol-6-yl)-pentanoylamino]-hexanoylamino}-butyric acid 2,5-dioxo-pyrrolidin-1-yl ester [ No CAS ]
  • 28
  • [ 72040-64-3 ]
  • [ 446878-26-8 ]
  • 29
  • [ 72040-64-3 ]
  • [ 446878-23-5 ]
  • 30
  • [ 72040-64-3 ]
  • [ 446878-21-3 ]
  • 31
  • [ 72040-64-3 ]
  • [ 446878-22-4 ]
  • 32
  • [ 72040-64-3 ]
  • [ 446878-24-6 ]
  • 33
  • [ 72040-64-3 ]
  • 14-hydroxy-3β-{6-[5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamido]hexanoyloxy}-5β,14β-card-20(22)-enolide [ No CAS ]
  • 34
  • [ 72040-64-3 ]
  • 22-(4-benzoylbenzoyloxy)-14-hydroxy-3β-{6-[5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamido]hexanoyloxy}-5β,14β-card-20(22)-enolide [ No CAS ]
 

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