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Chemical Structure| 14813-01-5 Chemical Structure| 14813-01-5
Chemical Structure| 14813-01-5

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Product Details of N-Benzyl-3-hydroxypiperidine

CAS No. :14813-01-5
Formula : C12H17NO
M.W : 191.27
SMILES Code : OC1CN(CC2=CC=CC=C2)CCC1
MDL No. :MFCD00023734
InChI Key :UTTCOAGPVHRUFO-UHFFFAOYSA-N
Pubchem ID :85773

Safety of N-Benzyl-3-hydroxypiperidine

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H317-H319
Precautionary Statements:P280-P305+P351+P338

Application In Synthesis of N-Benzyl-3-hydroxypiperidine

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 14813-01-5 ]

[ 14813-01-5 ] Synthesis Path-Downstream   1~4

  • 1
  • [ 14813-01-5 ]
  • [ 88712-56-5 ]
  • [ 91599-74-5 ]
  • (RS)-(SR)-1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid methyl 1-(phenylmethyl)-3-piperidinyl ester hydrochloride [ No CAS ]
  • 2
  • [ 50606-58-1 ]
  • [ 14813-01-5 ]
  • 3
  • [ 14813-01-5 ]
  • [ 74936-72-4 ]
  • [ 91599-74-5 ]
YieldReaction ConditionsOperation in experiment
36.2% Under ultrasound, 10 g of dihydropyridine main ring , i.e.,[2,6-dimethyl -4-(3-nitrophenyl)-l ,4-dihydropyridine-3,5-dicarboxylic acid monomethyl ester] was placed into 200 mL reaction flask, and 14 mL Nu,Nu-dimethylformamide (DMF) and 56 mL dichloromethane was added. To the resultant homogeneous suspension was added 2.4 mL of thionyl chloride under ice-bath, then the mixture was stirred for 1 hour to obtain a clear solution.Then, 6.3 g of pyridine (alcohol) side chain, i.e., [l-benzyl-3 -hydroxypiperidine] was added and stirred for 2.5 hours under ice-bath.The reaction solution was washed with 40 mL water (x 4) and 40 mL saturated saline solution (x 1). The dichloromethane solution was dried for two hours by adding 4 g of anhydrous sodium sulfate. Then, sodium sulfate solid was removed by filtering, and dichloromethane was recycled under reduced pressure to obtain a yellow to red crude crystal (herein after referred to as crude crystal of benidipine hydrochloride). The crude crystal mentioned above was dissolved in 100 mL acetone, and ultrasounded at 150 W and 40 MHz for 7 minutes, filtered under reduced pressure and dried to obtain 5.9 g of crystal as yellow powder (yield 36.2%)
 

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