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Chemical Structure| 17916-88-0 Chemical Structure| 17916-88-0
Chemical Structure| 17916-88-0

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N-Ac-D-Val-OH is a D-valine derivative, used for the preparation of selective CCR1 antagonists for the treatment of rheumatoid arthritis.

Synonyms: N-Acetyl-D-valine

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Product Details of N-Ac-D-Val-OH

CAS No. :17916-88-0
Formula : C7H13NO3
M.W : 159.18
SMILES Code : [H][C@@](NC(C)=O)(C(C)C)C(O)=O
Synonyms :
N-Acetyl-D-valine
MDL No. :MFCD00026457
InChI Key :IHYJTAOFMMMOPX-ZCFIWIBFSA-N
Pubchem ID :76475

Safety of N-Ac-D-Val-OH

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302
Precautionary Statements:P280-P305+P351+P338

Application In Synthesis of N-Ac-D-Val-OH

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 17916-88-0 ]

[ 17916-88-0 ] Synthesis Path-Downstream   1~21

  • 1
  • [ 640-68-6 ]
  • [ 108-24-7 ]
  • [ 17916-88-0 ]
  • 3
  • N-acetyl-DL-valine methyl ester [ No CAS ]
  • [ 17916-88-0 ]
  • 4
  • [ 96574-46-8 ]
  • [ 17916-88-0 ]
  • 5
  • [ 56430-36-5 ]
  • [ 17916-88-0 ]
  • [ 96-81-1 ]
  • 6
  • [ 52152-47-3 ]
  • [ 17916-88-0 ]
  • [ 96-81-1 ]
  • 7
  • [ 194661-11-5 ]
  • [ 17916-88-0 ]
  • [ 96-81-1 ]
  • 8
  • N-acetyl-DL-valine hexyl ester [ No CAS ]
  • [ 17916-88-0 ]
  • [ 96-81-1 ]
  • 9
  • [ 194661-10-4 ]
  • [ 17916-88-0 ]
  • [ 96-81-1 ]
YieldReaction ConditionsOperation in experiment
Also catalytic actions on the following substrates were confirmed: N-acetyl-D-valine; N-acetyl-D-alanine; and N-acetyl-D-leucine.
  • 13
  • [ 17916-88-0 ]
  • [ 804556-46-5 ]
  • Ac-D-Val-PyPro-Gly-D-Leu-NMe2 [ No CAS ]
  • 14
  • 2-methyl-4-iso-propyl-4H-oxazolin-5-one [ No CAS ]
  • [ 17916-88-0 ]
  • 15
  • N-acetyl-D,L-valine [ No CAS ]
  • [ 17916-88-0 ]
  • 16
  • [ 243968-43-6 ]
  • [ 17916-88-0 ]
  • [ 330192-92-2 ]
YieldReaction ConditionsOperation in experiment
90% With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In DMF (N,N-dimethyl-formamide); dichloromethane; at 20℃; EXAMPLE 45; 7-((2-(R)-Acetylamino-3-methyl-butyrylamino)methyl)-2-(oxalyl-amino)-4,7-dihydro-5H-thieno[2,3-c]pyran-3-carboxylic acid;. To a solution of <strong>[17916-88-0]Ac-D-Val-OH</strong> (0.17 g, 1.09 mmol) dissolved in dichloromethane (15 ml) was added N,N-dimethylformamide (1 ml), 1-hydroxybenzotriazole (0.15 g, 1.09 mmol) and 1-ethyl-3-(3-dimethylamino-propyl)carbodiimide hydrochloride (0.21 g, 1.09 mmol). The reaction mixture was stirred for 15 min. at room temperature at which time a solution of 2-amino-7-aminomethyl-4,7-dihydro-5H-thieno[2,3-c]pyran-3-carboxylic acid tert-butyl ester (0.31 g, 1.09 mmol) in dichloromethane (10 ml) was added followed by N,N-diisopropylethylamine (0.186 ml, 1.09 mmol). The resulting mixture was stirred over night at room temperature diluted with dichloromethane (10 ml) washed with 10 % aqueous citric acid (20 ml), sodium hydrogencarbonate, dried (MgSO4), filtered and the solvent was evaporated invacuo affording 415 mg (90 %) of 7-((2-(R)-acetylamino-3-methyl-butyrylamino)methyl)-2-amino-4,7-dihydro-5H-thieno[2,3-c]pyran-3-carboxylic acid tert-butyl ester as an oil.1H-NMR (CDCl3) δ 0.88 (t, 3H), 0.98 (t, 2H), 1.55 (s, 9H), 2.02 (d, 1H), 2.77 m, (2H), 3.40 (m, 1H), 4.14 (m, 1H). LC-MS: Rt = 5.17 min., m/z: 426.4 [M+H]+
90% Example 45 7-((2-Acetylamino-3-methyl-butyrylamino)methyl)-2-(oxalyl-amino)-4,7-dihydro-5H-thieno[2,3-c]pyran-3-carboxylic acid; To a solution of <strong>[17916-88-0]Ac-D-Val-OH</strong> (0.17 g, 1.09 mmol) dissolved in dichloromethane (15 ml) was added N,N-dimethylformamide (1 Ml), 1-hydroxybenzotriazole (0.15 g, 1.09 mmol) and 1-ethyl-3-(3-dimethylamino-propyl)carbodiimide hydrochloride (0.21 g, 1.09 mmol). The reaction mixture was stirred for 15 min. at room temperature at which time a solution of 2-amino-7-aminomethyl-4,7-dihydro-5H-thieno[2,3-c]pyran-3-carboxylic acid tert-butyl ester (0.31 g, 1.09 mmol) in dichloromethane (10 ml) was added followed by N-N-diisopropylethylamine (0.186 ml, 1.09 mmol). The resulting mixture was stirred over night at room temperature diluted with dichloromethane (10 ml) washed with 10% aqueous citric acid (20 ml), sodium hydrogencarbonate, dried (MgSO4), filtered and the solvent was evaporated in vacuo affording 415 mg (90%) of 7-((2-thieno[2,3-c]pyran-3-carboxylic acid tert-butyl ester as an oil.1H NMR (CDCl3) δ 0.88 (t, 3H), 0.98 (t, 2H), 1.55 (s, 9) 2.02 (d, 1H), 2.77 m, (2H), 3.40 (m, 1H), 4.14 (m, 1H).To a mixture of 7-((2-acetylamino-3-methyl-butyrylamino)methyl)-2-amino-4,7-dihydro-5H-thieno[2,3-c]pyran-3-carboxylic acid tert-butyl ester (0.4 g, 0.94 mmol) dissolved in dichloromethane (10 ml) and triethylamine (0.26 g, 1.87 mmol) cooled to 0 C. was added a solution of imidazol-1-yl-oxo-acetic acid tert-butyl ester (0.37 g, 1.87 mmol) in dichloromethane (10 ml). The resulting mixture was stirred for 18 h at room temperature diluted with dichloromethane (20 ml) washed with 1N hydrochloric acid (15 ml), saturated sodium hydrogencarbonate, dried (MgSO4), filtered and the solvent evaporated in vacuo which afforded 515 mg (97%) of 7-((2-acetylamino-3-methyl-butyrylamino)methyl)-2-(tert-butoxyoxalyl-amino)-4,7-dihydro-5H-thieno[2,3-c]pyran-3-carboxylic acid tert-butyl ester as an oil.LC-MS: Rt=7.11, Mw=554.4.HPLC: Rt=34.16, Area (%)=100, %.To a solution of the above 7-((2-acetylamino-3-methyl-butyrylamino)-methyl)-2-(tert-butoxyoxalyl-amino)-4,7-dihydro-5H-thieno[2,3-c]pyran-3-carboxylic acid tert-butyl ester (0.5 g, 0.90 mmol) dissolved in dichloromethane (3 ml) was added trifluoroacetic acid (1 ml) and the reaction mixture was stirred for 18 h at room temperature. Trifluoroacetic acid (4 ml) was added and the mixture was stirred for an additional 3 hours at room temperature. The volatiles were evaporated in vacuo (and stripped 3 times with dichloromethane) affording 282 mg (71%) of the title compound.Calculated for C18H23N3O8S, 2×H2O; C, 45.28%; H, 5.70%; N, 8.80%. Found: C, 45.20%; H, 5.50%; N, 8.80%.LC-MS: Rt=3.60, Mw=442.2
  • 17
  • [ 60218-18-0 ]
  • [ 17916-88-0 ]
  • [ 543-27-1 ]
  • [ 76718-84-8 ]
YieldReaction ConditionsOperation in experiment
With 4-methyl-morpholine; triethylamine; In dichloromethane; N,N-dimethyl acetamide; water; S. 2-[4-(N-Acetyl-D-valylamino)phenyl]-4-hydroxy-5-pyrimidine carboxylic acid imidazolide A suspension of 11.41 g (71.7 mmol) of <strong>[17916-88-0]N-acetyl-D-valine</strong> and 150 ml of dichloromethane is stirred at room temperature and 7.9 ml (71.7 mmol) of N-methylmorpholine is added. The resulting solution is cooled to -10 C. and 9.3 ml (71.7 mmol) of isobutyl chloroformate is added. The reaction mixture is stirred at -15+-5 C. for 45 min and an ice cold solution of 11.09 g (48 mmol) of 2-(4-aminophenyl)-4-hydroxy-5-pyrimidine carboxylic acid, 7.4 ml (52.8 mmol) of triethylamine, and 200 ml of N,N-dimethylacetamide is added while keeping the temperature below -10 C. The mixture is stirred at 0-5 C. for 2 hrs and overnight at room temperature. A small amount of solid is filtered and the filtrate is evaporated to dryness. Water is added to the residue and the resulting solid filtered, washed with water, ethyl acetate, and ether and dried to give 8.9 g of 2-[4-(N-acetyl-D-valylamino)phenyl]-4-hydroxy-5-pyrimidine carboxylic acid. A second crop, obtained from the aqueous filtrate, weighs 2.35 g. [α]D23 +4.50 (cl, pH 7).
  • 18
  • [ 6642-21-3 ]
  • [ 17916-88-0 ]
  • [ 96-81-1 ]
YieldReaction ConditionsOperation in experiment
With hydrogen;[(eta2-1,2,5,6)-1,5-cyclooctadiene][(Sp,S)-cis-2-(2-diphenylphosphinoethyl-kappaP)-(1-phenylphospholane-kappaP)]rhodium(I)hexafluoroantimonate; In methanol; at 20℃; for 3h;Product distribution / selectivity; In a glove box, an autoclave with a 20 mL glass tube insert equipped with a magnetic stirring bar was charged with the hydrogenation substrate (1 mmol), anhydrous degassed solvent (7 mL) and the metal complex pre-catalyst (0.01 mmol). After 10 cycles of evacuation and filling with hydrogen, the autoclave was pressurised to an appropriate initial pressure of hydrogen. The reaction mixture was stirred at room temperature and after the appropriate time the autoclave was opened, the reaction mixture was filtered through silica gel, concentrated and the residue was analysed by enantioselective GC.
With hydrogen;[(eta2-1,2,5,6)-1,5-cyclooctadiene][(Sp,R)-trans-2-(2-diphenylphosphinoethyl-kappaP)-(1-phenylphospholane-kappaP)]rhodium(I)hexafluoroantimonate; In tetrahydrofuran; at 20℃; for 3h;Product distribution / selectivity; In a glove box, an autoclave with a 20 mL glass tube insert equipped with a magnetic stirring bar was charged with the hydrogenation substrate (1 mmol), anhydrous degassed solvent (7 mL) and the metal complex pre-catalyst (0.01 mmol). After 10 cycles of evacuation and filling with hydrogen, the autoclave was pressurised to an appropriate initial pressure of hydrogen. The reaction mixture was stirred at room temperature and after the appropriate time the autoclave was opened, the reaction mixture was filtered through silica gel, concentrated and the residue was analysed by enantioselective GC.
With hydrogen;[(eta2-1,2,5,6)-1,5-cyclooctadiene][(Sp,R,R)-trans-2-(2-diphenylphosphino-2-methylethyl-kappaP)-(1-phenylphospholane-kappaP)]rhodium(I)hexafluoroantimonate; In tetrahydrofuran; at 20℃; for 3h;Product distribution / selectivity; In a glove box, an autoclave with a 20 mL glass tube insert equipped with a magnetic stirring bar was charged with the hydrogenation substrate (1 mmol), anhydrous degassed solvent (7 mL) and the metal complex pre-catalyst (0.01 mmol). After 10 cycles of evacuation and filling with hydrogen, the autoclave was pressurised to an appropriate initial pressure of hydrogen. The reaction mixture was stirred at room temperature and after the appropriate time the autoclave was opened, the reaction mixture was filtered through silica gel, concentrated and the residue was analysed by enantioselective GC.
With hydrogen;[(eta2-1,2,5,6)-1,5-cyclooctadiene][(Sp,R,S)-trans-2-(2-diphenylphosphino-2-methylethyl-kappaP)-(1-phenylphospholane-kappaP)]rhodium(I)hexafluoroantimonate; In tetrahydrofuran; at 20℃; for 3h;Product distribution / selectivity; In a glove box, an autoclave with a 20 mL glass tube insert equipped with a magnetic stirring bar was charged with the hydrogenation substrate (1 mmol), anhydrous degassed solvent (7 mL) and the metal complex pre-catalyst (0.01 mmol). After 10 cycles of evacuation and filling with hydrogen, the autoclave was pressurised to an appropriate initial pressure of hydrogen. The reaction mixture was stirred at room temperature and after the appropriate time the autoclave was opened, the reaction mixture was filtered through silica gel, concentrated and the residue was analysed by enantioselective GC.

  • 19
  • [ 17916-88-0 ]
  • [ 108-94-1 ]
  • [ 112790-04-2 ]
  • [ 1072014-00-6 ]
  • [ 1072014-01-7 ]
  • 20
  • [ 17916-88-0 ]
  • [ 108-94-1 ]
  • [ 43041-59-4 ]
  • [ 1072014-00-6 ]
  • [ 1072014-01-7 ]
  • 21
  • [ 1007882-27-0 ]
  • [ 17916-88-0 ]
  • [ 76-05-1 ]
  • N-[(2R)-1-[(2S)-2-{5-[4-(4-{2-[(2S)-1-[(2R)-2-acetamido-3-methylbutanoyl]pyrrolidin-2-yl]-1H-imidazol-5-yl}phenyl)phenyl]-1H-imidazol-2-yl}pyrrolidin-1-yl]-3-methyl-1-oxobutan-2-yl]acetamide trifluoroacetic acid [ No CAS ]
 

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