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Chemical Structure| 2971-79-1 Chemical Structure| 2971-79-1
Chemical Structure| 2971-79-1

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Product Details of Methyl 4-Piperidinecarboxylate

CAS No. :2971-79-1
Formula : C7H13NO2
M.W : 143.18
SMILES Code : N1CCC(CC1)C(=O)OC
MDL No. :MFCD00190578

Safety of Methyl 4-Piperidinecarboxylate

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H227-H315-H319-H335
Precautionary Statements:P210-P261-P264-P271-P280-P302+P352-P304+P340+P312-P305+P351+P338-P332+P313-P337+P313-P370+P378-P403+P233-P403+P235-P405-P501

Application In Synthesis of Methyl 4-Piperidinecarboxylate

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Upstream synthesis route of [ 2971-79-1 ]
  • Downstream synthetic route of [ 2971-79-1 ]

[ 2971-79-1 ] Synthesis Path-Upstream   1~3

  • 1
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YieldReaction ConditionsOperation in experiment
91% With formaldehyd; formic acid In water for 3 h; Heating / reflux To a stirred solution of methyl isonipecotate (L. OOG, 7.00 mmol) in methanol (25 ml) was added formic acid (5.52g, 12.00 mmol) and a solution of formaldehyde (2.67g, 35.00 mmol, 40percent aqueous) and the reaction heated at reflux. After 3 hours the reaction was cooled and concentrated under reduced pressure. The aqueous solution was basified with NAHC03 and extracted with DCM (3 x 30 ml), dried (MGSO4) and concentrated under reduced pressure to give a brown liquid (L. OOG, 910-.) ; b (270 MHz; CDC13 ; Me4Si), 1.69-2. 03 (6 H, m), 2.23-2. 32 (4H, m), 2.78- 2.83 (2H, m), 3.68 (3 H, s); M/Z (APCI) 158 (100percent [M+H] +), 126 (33, C7H120N).
References: [1] Patent: WO2004/58259, 2004, A1, . Location in patent: Page/Page column 26-27.
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  • [ 1690-75-1 ]
References: [1] Patent: US5380731, 1995, A, .
  • 3
  • [ 2971-79-1 ]
  • [ 50-00-0 ]
  • [ 1690-75-1 ]
References: [1] Journal of Organic Chemistry, 1955, vol. 20, p. 1761,1765.
[2] Archiwum Chemji i Farmacji, 1936, vol. 3, p. 109,113[3] Chemisches Zentralblatt, 1937, vol. 108, # II, p. 74.
 

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