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Chemical Structure| 1082949-67-4 Chemical Structure| 1082949-67-4

Structure of LY-2584702
CAS No.: 1082949-67-4

Chemical Structure| 1082949-67-4

LY-2584702

CAS No.: 1082949-67-4

LY2584702 is an orally available inhibitor of p70S6K signaling and inhibits p70S6K and prevents phosphorylation of the S6 subunit of ribosomes.

Synonyms: LY-2584702 free base

4.5 *For Research Use Only !

Cat. No.: A125389 Purity: 98+%

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Product Details of LY-2584702

CAS No. :1082949-67-4
Formula : C21H19F4N7
M.W : 445.42
SMILES Code : CN1C=C(C2=CC=C(F)C(C(F)(F)F)=C2)N=C1C3CCN(C4=C5C(NN=C5)=NC=N4)CC3
Synonyms :
LY-2584702 free base
MDL No. :MFCD18633220
InChI Key :FYXRSVDHGLUMHB-UHFFFAOYSA-N
Pubchem ID :25118925

Safety of LY-2584702

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Related Pathways of LY-2584702

MAPK
PI3K-AKT

Isoform Comparison

Biological Activity

In Vitro:

Cell Line
Concentration Treated Time Description References
Hepa1-6 hepatocytes 1 µM 24 hours LY blocked the kinase activity of S6K1, thus reducing pS6 expression and significantly decreasing lipid accumulation in hepatocytes. JCI Insight. 2022 Jul 22;7(14):e150461.
HEK293 cells 20 nM 3 hours Inhibition of p70S6K, reducing RPS6 phosphorylation at S235/236 and S240/244 J Biol Chem. 2023 Sep;299(9):105154.
Human bone marrow mesenchymal stem cells (BMSC) 1 µM LY treatment inhibited the differentiation of BMSC into adipocytes, suggesting that LY may reduce adipogenesis by inhibiting S6K1 activity. JCI Insight. 2022 Jul 22;7(14):e150461.

In Vivo:

Species
Animal Model
Administration Dosage Frequency Description References
C57BL/6N mice High-fat diet-induced obese mouse model Oral gavage 25 mg/kg Every 12 hours for 12 weeks LY treatment significantly reduced body weight gain and fat accumulation in high-fat diet-induced obese mice and ameliorated hepatic steatosis and dyslipidemia. JCI Insight. 2022 Jul 22;7(14):e150461.

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.25mL

0.45mL

0.22mL

11.23mL

2.25mL

1.12mL

22.45mL

4.49mL

2.25mL

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